dbPTM

RRP5_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRP5_SCHPO
UniProt AC	O74835
Protein Name	rRNA biogenesis protein rrp5
Gene Name	rrp5 {ECO:0000250\|UniProtKB:Q05022}
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1690
Subcellular Localization	Nucleus, nucleolus .
Protein Description	Involved in the biogenesis of rRNA. Required for the formation of 18S and 5.8S rRNA (By similarity)..
Protein Sequence	MAGNKRKRSNASEGSDSQGNERISSLSANEATQDFPRGGASSLTPLEYKEAVLEAKKDFMESASGTAELSKKTRPKKKGSKKSSKSELDNEENLKVHIQSLRYKNITPGSLILGQIAQINTLDLAVSLPNCLTGYVPITNISDKLSDRLDSIDNHAEDNAATEEEDGLNQIPDLMDLYKVGQWVRVSVTALGSENTTKTGKRHIELSLKPQDANGSAPEAADFVAGSMIQAVVSSIEDHGIVFDIGINNYTGFLSKKHINDFPFVEGQSLLCSVISKEDRIFHLSLTATSTKALEVMPSVQAILPGDYINVLVTDIKESGVIAKYMGVVDVTSDIYHSSPVKGEDLEDKFQLAKSVPARVLFVIPGDPPKIAVSFLPHVLTFNFATPNTPHPDQLDIGFIVNAAKVTYVSSSLGVFCDVGVPEISGFAHISRLSDKKVAGISPNSGPYKVDSTHEARIINYSYVDNLYILSFQQSVLNQQFLRIEDIEVGQFVDGTIAKLIPQGIVVTISEGINGLVPSTHMADIALQFPERRFKVGSSVKCRVLSTNVLRKRVLLTLKKSLLNTDLPLIYDYEQATPGTQTVGTLARIFEDGAIVEFYNSVRAFLPVSEMSEAYIRDAREHFKVGQTLSVTIVSCDPENRKMRVGCREQSWDAKRLERFENIKAGSVLSGIVLQKTEDSVIVDLGDKVTGVITLGQLCDGDLNKCSKVMNKLRASTKLAEVLVLRKDTSKKLISLSLKKSLVEAAKENRMPINITDLKEGIKYFGFVRNATTFGVFVEFCDGLVALVPKAYISEEYVPVPSAVYKPQQSVTCVCLSVELSQEKAFMSFKPLAQKQEKAVEFMESKYDIDNPVDETIKKTYDYVAGKITWAVVTSAKASQLNVDLAANVHGRVDVSEVFDNFGEIVDPNKPLKRFHKGDKIRVRVLGIHDSRNHKFLPISHRVSPKQFLELSVRPSILNMEPFSMKEPQFKKGDEVTGFVNNVSKECVWVSLTPSVNGRIPILDLTTDVKELNSLQKHFFLGKAIKCYVVNAEDSITLSAIGPLQGFENLTPGSRLVGKVTNVNEAGAILQLPGHMSGRVSRIDMFDDYDILPETKFTRNNLVGVCVLSVDVPNRKVALSARNSRTQSQPVEIKDKEINSVDDLKIGDICRGFVCNVANQGLFVTIGHNLIARVKIGELFDTFIKDWKPHFHVNQLVKGSIVGIDNDSKRIEMSLKQSKIKDSSEITKTFADIAVGSNLDGTVVKVGDYGVLIRIDGTDNIVGLCHKSEIADAVVLNISKLYSSGDKVRAHVLDVDSEKRRIALGLKSSYFDSDSDISMSDNEEDVEMRSEDQSDTSESEVGSKDDVQSEEVENLESAGDEDEEEEPSALQANGFDWTDGSTVFDKLADDTEDSEDEEDEEPKRKKSKSDRFDDEEKDLDEIPSTAADFERQLLSSPNSSLLWISYMAYHLNLNELQEAREVGKRALSTINYREEDEKLNVWMALLNLEVAYGTEDSLKEVFKEACAYCDALIVYEKLCGILIKGGKVDLADEYMQLMLKNFKQVPSVWIQYATFLLNNDKAEKAHGLLERSLQSLPKSEHVGIIEKFAILEFKNGDPERGRTIFEGLLSSYPKRLDLWNVLIDMEMKQDDPSIVRRLFQRLLALNLSTKKAKFAFKKWLAYEKNIGDDEGAEQVKRRAIEYVSESHSEN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
15	Phosphorylation	RSNASEGSDSQGNER CCCCCCCCCCCCCHH	30.00	27738172
24	Phosphorylation	SQGNERISSLSANEA CCCCHHHHHCCCCCC	31.29	29996109
25	Phosphorylation	QGNERISSLSANEAT CCCHHHHHCCCCCCC	24.79	25720772
27	Phosphorylation	NERISSLSANEATQD CHHHHHCCCCCCCCC	30.88	25720772
338	Phosphorylation	VTSDIYHSSPVKGED EECCCCCCCCCCCCC	21.26	21712547
339	Phosphorylation	TSDIYHSSPVKGEDL ECCCCCCCCCCCCCH	22.02	21712547
1391	Phosphorylation	FDKLADDTEDSEDEE HHHHCCCCCCCCCCC	42.09	28889911
1394	Phosphorylation	LADDTEDSEDEEDEE HCCCCCCCCCCCCCC	40.49	28889911
1603	Phosphorylation	GDPERGRTIFEGLLS CCHHHCCCHHHHHHH	32.61	25720772
1684	Phosphorylation	RRAIEYVSESHSEN- HHHHHHHHHHCCCC-	32.26	28889911
1686	Phosphorylation	AIEYVSESHSEN--- HHHHHHHHCCCC---	25.47	28889911
1688	Phosphorylation	EYVSESHSEN----- HHHHHHCCCC-----	48.38	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRP5_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRP5_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRP5_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RRP5_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRP5_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-1391; SER-1394; SER-1684AND SER-1686, AND MASS SPECTROMETRY.	18257517 [Abstract]