RRP40_SCHPO - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RRP40_SCHPO
• UniProt AC: O13903
• Protein Name: Exosome complex component rrp40
• Gene Name: rrp40
• Organism: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
• Sequence Length: 240
• Subcellular Localization: Cytoplasm. Nucleus, nucleolus.
• Protein Description: Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and cryptic unstable transcripts (CUTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and in RNA surveillance pathways, preventing translation of aberrant mRNAs. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. rrp40 as peripheral part of the Exo-9 complex is thought to stabilize the hexameric ring of RNase PH-domain subunits (By similarity)..
• Protein Sequence: MAEVEEKGLLSYYFPGERIPDSIISQDGSIRLGPGLVFQKKDREEEIVVSKAGRLHQTGKNAMLIDSRTKRYIPATNDQVIGQIISRFAEGYRVDIGSAHIAQLNALAFENVTRKSRPNLNVGSLVYARVSLADRDMEPELECFDATTGKAAGYGELKNGYMITGLSLSHCRKLILPKNTLLQTLGSYIPFEIAVGMNGRVWVNSENLSTTVLICTAIRNCEFMSDEEQIKYCKDLIKKL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Oops, there are no PTM records of RRP40_SCHPO !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RRP40_SCHPO !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RRP40_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RRP40_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PANB_SCHPO	SPAC5H10.09c	physical	26771498

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.