dbPTM

RRB1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RRB1_SCHPO
UniProt AC	Q9P783
Protein Name	Ribosome assembly protein rrb1
Gene Name	rrb1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	480
Subcellular Localization	Cytoplasm . Nucleus, nucleolus .
Protein Description	Involved in regulation of L3 expression and stability and plays a role in early 60S ribosomal subunit assembly. May be required for proper assembly of pre-ribosomal particles during early ribosome biogenesis, presumably by targeting L3 onto the 35S precursor rRNA (By similarity)..
Protein Sequence	MSKRAAEETVEFNSKNGPGQRGTVADNVDTEMGEFEDAYEDEIESEEEYIEADGEKDNGMDEEEQNDAQPSKIPWLPGGKINADEKLVADPSVYEMLHNIQVKWPFLSFDILQDSLGEERRAWPHQMYLVGGSQALDSNDNELTVMKLSQLYKTQHDENDDASDNSDVEEDPILEHKSISTKGACNRVRSARRPANSSKESLLASFHETGKVHIWDIAPHLRSLDSPGVMVSRKENSPLYTVNRHKTEGYALDWSPFEYSLLSGDNANEIFLTKYSNGGWQTDSSPFLSHTAAVEDLQWSPSEKNVFSSCSCDGTFRIWDVRNKQKTSALTVNAHPGVDVNVLSWNTRVPNLLATGADNGVWSVWDLRSLKSSSSVATPVASFKWHRAPIYSIEWHPNEDSVIGVVGADNQISLWDLSVELDEEEQDSRAAEGLQDVPPQLMFIHMGQQEIKEMHWHRQIPGTIVSTAMTGINVFKTITF

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
45	Phosphorylation	AYEDEIESEEEYIEA HHHHHCCCHHHHHHH	56.84	29996109
154	Phosphorylation	KLSQLYKTQHDENDD EHHHHHHHCCCCCCC	19.99	21712547
163	Phosphorylation	HDENDDASDNSDVEE CCCCCCCCCCCCCCC	44.30	28889911
166	Phosphorylation	NDDASDNSDVEEDPI CCCCCCCCCCCCCCC	48.28	28889911

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RRB1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RRB1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RRB1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RRB1_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RRB1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-163 AND SER-166, ANDMASS SPECTROMETRY.	18257517 [Abstract]