RPN2_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPN2_RAT
• UniProt AC: P25235
• Protein Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2
• Gene Name: Rpn2
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 631
• Subcellular Localization: Endoplasmic reticulum . Endoplasmic reticulum membrane; Multi-pass membrane protein .
• Protein Description: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains..
• Protein Sequence: MAPPGSSAVFLLALTITASTQALTPTHYLTKHDVERLKASLDRPFTSLESAFYSIVGLNSLGAQVPDVKKACAFIKSNLDPSNVDSLFYAAQSSQVLSGCEISVSNETRDLLLAAVSEDSSVAQIYHAVAALSGFGLPLASHEALGALTARLSKEETVLATVQALHTASHLSQQADLRNIVEEIEDLVARLDELGGVYLQFEEGLELTALFVAATYKLMDHVGTEPSIKEDQVIQLMNTIFSKKNFESLSEAFSVASAAAALSQNRYHVPVVVVPEGSASDTQEQAILRLQVSSVLSQPLAQAAVKLEHAKSVASRATVLQKMPFSLVGDVFELNFKNVKLPSGYYDFSVRVEGDNRYIANTVELRVKISTEVGITNVDLSTVDKDQSIAPKTTRVTYPAKAKGTFIADSHQNFALFFQLVDVNTGAELTPHQTFVRLHNQKTGQEVVFVAEPDNKNVYKFELDTSERKIEFDSASGTYTLYLIIGDATLKNPILWNVADVVIKFPEEEAPSTVLSQNLFTPKQEIQHLFREPEKRPPTVVSNTFTALILSPLLLLFALWIRIGANVSNFTFAPSTVIFHLGHAAMLGLMYVYWTQLNMFQTLKYLAVLGTVTFLAGNRMLAQQAVKRTAH

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	N-linked_Glycosylation	GCEISVSNETRDLLL CCEEEECHHHHHHHH	53.13	-
306	Acetylation	PLAQAAVKLEHAKSV HHHHHHHHHHHHHHH	43.35	22902405
370	Phosphorylation	VELRVKISTEVGITN EEEEEEEECCCCCCE	16.88	27097102
371	Phosphorylation	ELRVKISTEVGITNV EEEEEEECCCCCCEE	37.86	27097102
376	Phosphorylation	ISTEVGITNVDLSTV EECCCCCCEEECCCC	24.22	27097102
381	Phosphorylation	GITNVDLSTVDKDQS CCCEEECCCCCCCCC	23.17	27097102
382	Phosphorylation	ITNVDLSTVDKDQSI CCEEECCCCCCCCCC	39.77	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPN2_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPN2_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPN2_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RPN2_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.