dbPTM

RPGF5_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPGF5_RAT
UniProt AC	P83900
Protein Name	Rap guanine nucleotide exchange factor 5
Gene Name	Rapgef5
Organism	Rattus norvegicus (Rat).
Sequence Length	580
Subcellular Localization	Nucleus.
Protein Description	Guanine nucleotide exchange factor (GEF) for RAP1A, RAP2A and MRAS/M-Ras-GTP. Its association with MRAS inhibits Rap1 activation (By similarity)..
Protein Sequence	MGSSRLRVFDPPLERKDSAALSERQLPLPTFDVPYFKYIDEEDEDDEWGSRSQSSTEDDSVDSLLSDRYVVVSGTPEKILEHLLNDLHLAEVQHKETETLLDDFLLTYTVFMTTDDLCQALLRHYSAKKYQGEEENSDVPCRKRKVLHLVSQWISLYKDWLHEDEHSKMFLKTIYRNVLDDVYEYPILEKELKEFQKILGMHRRHTVDEYSPQKKNKALFHQFSLKENWLQHRGTVAETEEIFCHVYVTEHSYISVKAKVSSTAQEILKVVAEKLQRAEEDLALVAIMFSGEKHEFQPNDLAISKSLEASGRIYVYRKDLADTLNPFAENEESQQRSMRILGMNTWDLALELMSFDWSLFNSIHEQELIYFTFSRQGSGEHTVNLSLLLQRCNEVQLWVATEILLCSQLGKRVQLVKKFIKIAAHCKAQQNLNSFFAIVMGLNTASVSRLSQTWEKIPGKFKKLFSELESLTDPSLNHKAYRDAFKKMKPPKIPFMPLLLKDVTFIHEGNKTFLDNLVNFEKLHMIADTVRTLRHCRTNQFGSDMSPKEQQELKSYVNHLYVIDSQQALFELSHRLEPRA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
206	Phosphorylation	LGMHRRHTVDEYSPQ HCCCCCCCCCCCCCC	28.04	28432305
224	Phosphorylation	KALFHQFSLKENWLQ HHHHHHCCCHHHHHH	31.77	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RPGF5_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPGF5_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPGF5_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RPGF5_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPGF5_RAT

Related Literatures of Post-Translational Modification