dbPTM

RPGF3_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPGF3_RAT
UniProt AC	Q9Z1C8
Protein Name	Rap guanine nucleotide exchange factor 3
Gene Name	Rapgef3
Organism	Rattus norvegicus (Rat).
Sequence Length	926
Subcellular Localization	Cytoplasm. Membrane Peripheral membrane protein.
Protein Description	Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity)..
Protein Sequence	MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEGSLDFRVSLEQATTEHVHKAGKLLYRHLLATYPTLIRDRKYHLRLHRQCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPQPAGTHDVEEELVEAMALLSQRGPDALLTVALRKSPGQRTDEELDLIFEELVHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTRGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPCTQLFAALLHHFHVEPSEPAGGSEQERSTYICNKRQQILRLVSRWVALYSPMLRSDPVATSFLQKLSDLVSRDTRLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWFPNHEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGLNERIFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTEHDWNLFNRIHQVELIHYVLGPQHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGPRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDMTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQASRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
79	Phosphorylation	RWTPLTNSEGSLDFR EEEECCCCCCCEEEE	37.79	-
376	Phosphorylation	TSQGAGPSRPPTPGR CCCCCCCCCCCCCCC	57.40	22108457
531	Phosphorylation	ENGCGNVSPQTKARN CCCCCCCCHHHCCCC	18.45	27097102
534	Phosphorylation	CGNVSPQTKARNAPV CCCCCHHHCCCCCCC	30.01	30181290
867	Phosphorylation	SHSTAPLSPLRSRVS HCCCCCCCHHHHHCC	22.34	27097102

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RPGF3_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPGF3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPGF3_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RPGF3_RAT !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPGF3_RAT

Related Literatures of Post-Translational Modification