RPGF3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RPGF3_MOUSE
• UniProt AC: Q8VCC8
• Protein Name: Rap guanine nucleotide exchange factor 3
• Gene Name: Rapgef3
• Organism: Mus musculus (Mouse).
• Sequence Length: 918
• Subcellular Localization: Cytoplasm. Membrane; Peripheral membrane protein.
• Protein Description: Guanine nucleotide exchange factor (GEF) for RAP1A and RAP2A small GTPases that is activated by binding cAMP. Through simultaneous binding of PDE3B to RAPGEF3 and PIK3R6 is assembled in a signaling complex in which it activates the PI3K gamma complex and which is involved in angiogenesis. Plays a role in the modulation of the cAMP-induced dynamic control of endothelial barrier function through a pathway that is independent on Rho-mediated signaling. Required for the actin rearrangement at cell-cell junctions, such as stress fibers and junctional actin (By similarity)..
• Protein Sequence: MKVSWPGENHWQVGPAVVESPAVGAPQVGGLPDVVPEGTLLNMVLKRMHRPRCCSYQLVFEHRRPSCIQGLRWTPLTNSEDSLDFRVSLEQATTEHVHKAGKLLHRHLLATYPTLIRDRKYHLRLYRHCCSGRELVDGILALGLGVHSRSQAVGICQVLLDEGALCHVKHDWTFQDRDAQFYRFPGPEPEPTGTQDVEEELVEAMALLSQRGPDALLTVALRKPPGQRTDEELDLIFEELLHIKAVAHLSNSVKRELAAVLLFEPHSKAGTVLFSQGDKGTSWYIIWKGSVNVVTHGKGLVTTLHEGDDFGQLALVNDAPRAATIILRENNCHFLRVDKQDFNRIIKDVEAKTMRLEEHGKVVLVLERTSQGAGPSRPPTPGRNRYTVMSGTPEKILELLLEAMRPDSSAHDPTETFLSDFLLTHSVFMPSTQLFTALLHHFHVEPADPAGGSEQEHSTYICNKRQQILRLVGRWVALYSPMLHSDPVATSFLQKLSDLVSRDARLSNLLREQYPERRRHHRLENGCGNVSPQTKARNAPVWLPNQEEPLPSSAGAIRVGDKVPYDICRPDHSVLTLHLPVTASVREVMAALAHEDHWTKGQVLVKVNSAGDVVGLQPDARGVATSLGLNERLFVVDPQEVHELTPHPEQLGPTLGSSEMLDLVSAKDLAGQLTDHDWNLFNRIHQVQEHLRDVTTANLERFMRRFNELQYWVATELCLCPVPGSRAQLLRKFIKLAAHLKEQKNLNSFFAVMFGLSNSAISRLAHTWERLPHKVRKLYSALERLLDPSWNHRVYRLALTKLSPPVIPFMPLLLKDVTFIHEGNHTLVENLINFEKMRMMARAVRMLHHCRSHSTAPLSPLRSRVSHIHEDSQGSRISTCSEQSLSTRSPASTWAYVQQLKVIDNQRELSRLSRELEP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
66	Phosphorylation	VFEHRRPSCIQGLRW EECCCCCCCCCCCEE	23.26	25521595
79	Phosphorylation	RWTPLTNSEDSLDFR EEEECCCCCCCCCEE	37.23	19060867
82	Phosphorylation	PLTNSEDSLDFRVSL ECCCCCCCCCEEEEH	26.28	21082442
347	Ubiquitination	QDFNRIIKDVEAKTM HHHHHHHHHHHHHEE	54.04	-
369	Phosphorylation	VVLVLERTSQGAGPS EEEEEEECCCCCCCC	18.94	22871156
370	Phosphorylation	VLVLERTSQGAGPSR EEEEEECCCCCCCCC	32.60	22871156
376	Phosphorylation	TSQGAGPSRPPTPGR CCCCCCCCCCCCCCC	57.40	25338131
380	Phosphorylation	AGPSRPPTPGRNRYT CCCCCCCCCCCCCEE	40.85	19060867
531	Phosphorylation	ENGCGNVSPQTKARN CCCCCCCCCCCCCCC	18.45	25521595
534	Phosphorylation	CGNVSPQTKARNAPV CCCCCCCCCCCCCCE	30.01	23984901
854	Phosphorylation	LHHCRSHSTAPLSPL HHHHHHCCCCCCCCH	27.75	29472430
855	Phosphorylation	HHCRSHSTAPLSPLR HHHHHCCCCCCCCHH	27.20	18846507
859	Phosphorylation	SHSTAPLSPLRSRVS HCCCCCCCCHHHHHC	22.34	26824392
881	Phosphorylation	GSRISTCSEQSLSTR CCCCEECCCCCCCCC	38.47	21183079
884	Phosphorylation	ISTCSEQSLSTRSPA CEECCCCCCCCCCCH	21.89	21183079

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RPGF3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RPGF3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RPGF3_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARBK1_HUMAN	ADRBK1	physical	20861385

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.