| UniProt ID | RPB1B_HUMAN | |
|---|---|---|
| UniProt AC | Q9GZM3 | |
| Protein Name | DNA-directed RNA polymerase II subunit RPB11-b1 | |
| Gene Name | POLR2J2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 115 | |
| Subcellular Localization | Nucleus. | |
| Protein Description | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).. | |
| Protein Sequence | MNAPPAFESFLLFEGEKITINKDTKVPKACLFTINKEDHTLGNIIKSQLLKDPQVLFAGYKVPHPLEHKIIIRVQTTPDYSPQEAFTNAITDLISELSLLEERFRTCLLPLRLLP | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 9 | Phosphorylation | NAPPAFESFLLFEGE CCCCCCCEEEEEECE | 18.10 | 28348404 | |
| 22 | Ubiquitination | GEKITINKDTKVPKA CEEEEECCCCCCCEE | 64.02 | 23000965 | |
| 25 | Ubiquitination | ITINKDTKVPKACLF EEECCCCCCCEEEEE | 66.87 | 23000965 | |
| 36 | Ubiquitination | ACLFTINKEDHTLGN EEEEEEECCCCCHHH | 61.75 | 29967540 | |
| 40 | Phosphorylation | TINKEDHTLGNIIKS EEECCCCCHHHHHHH | 49.00 | - | |
| 46 | Ubiquitination | HTLGNIIKSQLLKDP CCHHHHHHHHHHCCC | 28.49 | 21890473 | |
| 46 (in isoform 1) | Ubiquitination | - | 28.49 | 21890473 | |
| 51 | Ubiquitination | IIKSQLLKDPQVLFA HHHHHHHCCCCEEEE | 75.78 | 32015554 | |
| 51 | Ubiquitination | IIKSQLLKDPQVLFA HHHHHHHCCCCEEEE | 75.78 | 21906983 | |
| 51 (in isoform 1) | Ubiquitination | - | 75.78 | 21890473 | |
| 60 | Phosphorylation | PQVLFAGYKVPHPLE CCEEEECCCCCCCCC | 12.84 | - | |
| 61 | Ubiquitination | QVLFAGYKVPHPLEH CEEEECCCCCCCCCC | 48.66 | 33845483 | |
| 61 (in isoform 1) | Ubiquitination | - | 48.66 | 21890473 | |
| 69 | Ubiquitination | VPHPLEHKIIIRVQT CCCCCCCEEEEEEEE | 26.65 | - | |
| 98 | Phosphorylation | TDLISELSLLEERFR HHHHHHHHHHHHHHH | 27.19 | 26437602 | |
| 106 | Phosphorylation | LLEERFRTCLLPLRL HHHHHHHHHHHHHHC | 12.56 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RPB1B_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RPB1B_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RPB1B_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RPB1B_HUMAN !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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