dbPTM

RPA34_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RPA34_SCHPO
UniProt AC	Q9USZ4
Protein Name	DNA-directed RNA polymerase I subunit rpa34
Gene Name	rpa34
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	251
Subcellular Localization	Nucleus, nucleolus.
Protein Description	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors (By similarity)..
Protein Sequence	MAKSSEFVNEESSEDESSVSSIEDQHSSKEPEQSVESNNHGESNAQEDVAEIAGLEKVQGKPVLTTNDLKKESNVFLVRLPPGMSADQISQLKVGSKPTVELKQENENTYQIREESTSSVRVFLPDEQGSYTSNEIKTGYVITETPKISQNIDTGITIPTQAPLVPQRKNLRQHFRPIGDAVGPESEPEAEPKSGIKEHILQETGDATVEELQNKGKEKQKELKKGKREKKDEEEKPKKKKQKKSSKKEKN

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	SEFVNEESSEDESSV HHCCCCCCCCCCHHC	32.61	24763107
13	Phosphorylation	EFVNEESSEDESSVS HCCCCCCCCCCHHCH	52.96	28889911
20	Phosphorylation	SEDESSVSSIEDQHS CCCCHHCHHHHHHCC	27.78	25720772
186	Phosphorylation	GDAVGPESEPEAEPK CCCCCCCCCCCCCCC	62.68	28889911
194	Phosphorylation	EPEAEPKSGIKEHIL CCCCCCCCCHHHHHH	57.37	25720772

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RPA34_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RPA34_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RPA34_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RPA34_SCHPO !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RPA34_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-13, AND MASSSPECTROMETRY.	18257517 [Abstract]