RPA34_MOUSE - dbPTM
RPA34_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RPA34_MOUSE
UniProt AC Q76KJ5
Protein Name DNA-directed RNA polymerase I subunit RPA34
Gene Name Cd3eap
Organism Mus musculus (Mouse).
Sequence Length 399
Subcellular Localization Nucleus, nucleolus . Accumulates in the nucleolus of exponentially growing cells.
Protein Description DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase I which synthesizes ribosomal RNA precursors. Involved in UBTF-activated transcription, presumably at a step following PIC formation..
Protein Sequence MAGTQACSATRFSCPPHFTEMSPDSEPSRFSLEALTGPDTELWLIQAPADFAPQCLNGRRVPLSGSKTVKGKLDGKKHRYRVFTSSPQAREATLLASSSEAGGRLTCAPAPSGSLRIMEGPQEYLLSRVPLQLIPTSLPPQIPAGLRPRFSAFGGSPPVTGPGSASALRSPTSGKRKSTRKGTDASSDTQEAVNRHGAMEVKTALGNLGVSVKKRKRYFMQEEMEAKTMEPVAELPVPSATSSKKRKKSKGTETSQVEHTEPVAQTEPPEGTFLFPTKKRKRQKEADGTEEVDGIVADSQPQVIVEAQEETILLSPTKKRRKEKRQNLGMEAEMGPPGVLMVTEHSEHGLQAEVALVSPKKTKKKKGKRVGETEAALPDDFEPQGALAPSKKKERGARL
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
1Acetylation-------MAGTQACS
-------CCCCCCCC		7.57-
66PhosphorylationRRVPLSGSKTVKGKL
CCCCCCCCCCEECEE		23.0621454597
68PhosphorylationVPLSGSKTVKGKLDG
CCCCCCCCEECEECC		29.1921454597
80PhosphorylationLDGKKHRYRVFTSSP
ECCCEEEEEEEECCH		15.7323984901
84PhosphorylationKHRYRVFTSSPQARE
EEEEEEEECCHHHHH		25.9923984901
85PhosphorylationHRYRVFTSSPQAREA
EEEEEEECCHHHHHH		28.6725159016
86PhosphorylationRYRVFTSSPQAREAT
EEEEEECCHHHHHHH		20.2725159016
107S-nitrosylationEAGGRLTCAPAPSGS
CCCCCEEEEECCCCC		5.1720925432
107S-nitrosocysteineEAGGRLTCAPAPSGS
CCCCCEEEEECCCCC		5.17-
124PhosphorylationIMEGPQEYLLSRVPL
EEECCHHHHHHCCCC		14.01-
137PhosphorylationPLQLIPTSLPPQIPA
CCCCCCCCCCCCCCC		33.26-
151PhosphorylationAGLRPRFSAFGGSPP
CCCCCCCCCCCCCCC		24.7826745281
156PhosphorylationRFSAFGGSPPVTGPG
CCCCCCCCCCCCCCC		26.8122942356
160PhosphorylationFGGSPPVTGPGSASA
CCCCCCCCCCCCHHH		43.3525266776
164PhosphorylationPPVTGPGSASALRSP
CCCCCCCCHHHHCCC		23.3727087446
166PhosphorylationVTGPGSASALRSPTS
CCCCCCHHHHCCCCC		29.5422942356
170PhosphorylationGSASALRSPTSGKRK
CCHHHHCCCCCCCCC		33.1227087446
172PhosphorylationASALRSPTSGKRKST
HHHHCCCCCCCCCCC		51.8922942356
173PhosphorylationSALRSPTSGKRKSTR
HHHCCCCCCCCCCCC		45.7822942356
183PhosphorylationRKSTRKGTDASSDTQ
CCCCCCCCCCCHHHH		31.2825159016
186PhosphorylationTRKGTDASSDTQEAV
CCCCCCCCHHHHHHH		31.4025159016
187PhosphorylationRKGTDASSDTQEAVN
CCCCCCCHHHHHHHH		46.5325521595
189PhosphorylationGTDASSDTQEAVNRH
CCCCCHHHHHHHHHH		30.2025159016
211PhosphorylationALGNLGVSVKKRKRY
HHHHCCCCHHHHHHH		26.8128725479
241PhosphorylationELPVPSATSSKKRKK
CCCCCCCCCCCCCCC		37.5615345747
249PhosphorylationSSKKRKKSKGTETSQ
CCCCCCCCCCCCCCC		39.0825338131
277PhosphorylationEGTFLFPTKKRKRQK
CCCCCCCCCCCCCHH		41.69-
299PhosphorylationVDGIVADSQPQVIVE
CCCEEECCCCEEEEE		33.7430635358
311PhosphorylationIVEAQEETILLSPTK
EEEECCCEEEECCCH		19.0330635358
315PhosphorylationQEETILLSPTKKRRK
CCCEEEECCCHHHHH		27.3830635358
317PhosphorylationETILLSPTKKRRKEK
CEEEECCCHHHHHHH		45.9130635358
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RPA34_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RPA34_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RPA34_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RPA34_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RPA34_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Phosphoproteomic analysis of the developing mouse brain.";
Ballif B.A., Villen J., Beausoleil S.A., Schwartz D., Gygi S.P.;
Mol. Cell. Proteomics 3:1093-1101(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-241, AND MASSSPECTROMETRY.

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