RNLS_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNLS_HUMAN
• UniProt AC: Q5VYX0
• Protein Name: Renalase {ECO:0000303|PubMed:15841207}
• Gene Name: RNLS
• Organism: Homo sapiens (Human).
• Sequence Length: 342
• Subcellular Localization: Secreted .
• Protein Description: Catalyzes the oxidation of the less abundant 1,2-dihydro-beta-NAD(P) and 1,6-dihydro-beta-NAD(P) to form beta-NAD(P)(+). The enzyme hormone is secreted by the kidney, and circulates in blood and modulates cardiac function and systemic blood pressure. Lowers blood pressure in vivo by decreasing cardiac contractility and heart rate and preventing a compensatory increase in peripheral vascular tone, suggesting a causal link to the increased plasma catecholamine and heightened cardiovascular risk. High concentrations of catecholamines activate plasma renalase and promotes its secretion and synthesis..
• Protein Sequence: MAQVLIVGAGMTGSLCAALLRRQTSGPLYLAVWDKAEDSGGRMTTACSPHNPQCTADLGAQYITCTPHYAKKHQRFYDELLAYGVLRPLSSPIEGMVMKEGDCNFVAPQGISSIIKHYLKESGAEVYFRHRVTQINLRDDKWEVSKQTGSPEQFDLIVLTMPVPEILQLQGDITTLISECQRQQLEAVSYSSRYALGLFYEAGTKIDVPWAGQYITSNPCIRFVSIDNKKRNIESSEIGPSLVIHTTVPFGVTYLEHSIEDVQELVFQQLENILPGLPQPIATKCQKWRHSQVTNAAANCPGQMTLHHKPFLACGGDGFTQSNFDGCITSALCVLEALKNYI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	LIVGAGMTGSLCAAL EEECCCHHHHHHHHH	23.77	24043423
14	Phosphorylation	VGAGMTGSLCAALLR ECCCHHHHHHHHHHH	15.88	24043423
44	Phosphorylation	EDSGGRMTTACSPHN CCCCCCCCCCCCCCC	15.18	24043423
45	Phosphorylation	DSGGRMTTACSPHNP CCCCCCCCCCCCCCC	19.14	24043423
48	Phosphorylation	GRMTTACSPHNPQCT CCCCCCCCCCCCCCC	27.08	24043423
55	Phosphorylation	SPHNPQCTADLGAQY CCCCCCCCCCCCCEE	20.26	24043423
62	Phosphorylation	TADLGAQYITCTPHY CCCCCCEEEECCHHH	9.54	22817900
64	Phosphorylation	DLGAQYITCTPHYAK CCCCEEEECCHHHHH	12.85	24043423
66	Phosphorylation	GAQYITCTPHYAKKH CCEEEECCHHHHHHH	12.40	24043423
69	Phosphorylation	YITCTPHYAKKHQRF EEECCHHHHHHHHHH	22.71	24043423
113	Phosphorylation	VAPQGISSIIKHYLK ECCCCHHHHHHHHHH	26.81	24719451
189	Phosphorylation	RQQLEAVSYSSRYAL HHHHHHCCHHHHHHH	26.75	-
190	Phosphorylation	QQLEAVSYSSRYALG HHHHHCCHHHHHHHH	12.22	-
191	Phosphorylation	QLEAVSYSSRYALGL HHHHCCHHHHHHHHH	10.79	-
192	Phosphorylation	LEAVSYSSRYALGLF HHHCCHHHHHHHHHH	22.52	-
216	Phosphorylation	PWAGQYITSNPCIRF CCCHHCCCCCCEEEE	19.95	29449344
217	Phosphorylation	WAGQYITSNPCIRFV CCHHCCCCCCEEEEE	29.26	29449344
225	Phosphorylation	NPCIRFVSIDNKKRN CCEEEEEEECCCCCC	22.85	29449344

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNLS_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNLS_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNLS_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RNLS_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.