RNF6_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RNF6_MOUSE
• UniProt AC: Q9DBU5
• Protein Name: E3 ubiquitin-protein ligase RNF6
• Gene Name: Rnf6
• Organism: Mus musculus (Mouse).
• Sequence Length: 667
• Subcellular Localization: Nucleus. Cytoplasm. Cell projection, axon. Nucleus, PML body. Localizes to the PML nuclear bodies in Sertoli cells.
• Protein Description: E3 ubiquitin-protein ligase mediating 'Lys-48'-linked polyubiquitination of LIMK1 and its subsequent targeting to the proteasome for degradation. Negatively regulates axonal outgrowth through regulation of the LIMK1 turnover. Mediates 'Lys-6' and 'Lys-27'-linked polyubiquitination of AR/androgen receptor thereby modulating its transcriptional activity. May also bind DNA and function as a transcriptional regulator..
• Protein Sequence: MDPSRSRSGGSGEESSFQENERRWQQERLHREEAYYQFINELSDEDYRLMRDHNLLGTPGEITSEELQQRLERAKEQLASQPGSDSAASDGDSESLRAHSDEDSLLRWLNTFRRTGNVTRSGQNGNQSWRAVSRTNPNSGEFGFSLEIHINPDNRGSEMHGEDSTDIPLSGVNREHRQQRPSSPVARRTRSQTSMSSSGPRGRRGARRQGSVQGSFATLGRLRNGIGVALGVPRVSAPRTNVINSHTNQSDGSTLRQGGRQRFGAAHIWENGARSNVTVRNTNQRLEPIRLRPAFSSRSRSPIQRQNGTVHHNSQRQGRPVQQTGRNRSVRHRGVTRVFLEQGREHRGTDYTPLSNSRLVSRITVEEGESSRSSAATQRHPAITLDLQVRRIRPGETRDRDSIANRTRSRAGLAESTVESTSGGFHRTISHLERSGVRTYVSTITVPLRRISENDVVEPSSVALRSILRQIMTGFGELSSLMEVEPASENQSNGQRLPEVYLELSNGDAADDSGQHGRASSQASQAQDGAEMLAVREPAPPQARPSGSRSRRQLGRADSVVEAGTLPILRLAHFFLLNEGDDDPIRGLTKEQIDNLSTRSYEQDGVDSELGKVCSVCISDYVAGNKLRQLPCLHEFHIHCIDRWLSENCTCPVCRRPVLEFGATSSG

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
58	Phosphorylation	RDHNLLGTPGEITSE HHCCCCCCCCCCCHH	28.26	22817900
64	Phosphorylation	GTPGEITSEELQQRL CCCCCCCHHHHHHHH	34.43	21183079
104	Phosphorylation	RAHSDEDSLLRWLNT HHCCCHHHHHHHHHH	27.53	27841257
182	Phosphorylation	EHRQQRPSSPVARRT HHHHHCCCCHHHHHH	49.84	23684622
183	Phosphorylation	HRQQRPSSPVARRTR HHHHCCCCHHHHHHH	26.52	26824392
211	Phosphorylation	RGARRQGSVQGSFAT CCCCCCCCCCCCHHH	11.70	27149854
299	Phosphorylation	RPAFSSRSRSPIQRQ CCCCCCCCCCCCCCC	38.77	27681418
301	Phosphorylation	AFSSRSRSPIQRQNG CCCCCCCCCCCCCCC	27.83	23684622
452	Phosphorylation	TVPLRRISENDVVEP EEECCCCCCCCCCCC	28.65	21454597
466	Phosphorylation	PSSVALRSILRQIMT CCHHHHHHHHHHHHH	27.16	30387612
559	Phosphorylation	RQLGRADSVVEAGTL HHHCCCCCHHHHCHH	27.38	25521595
565	Phosphorylation	DSVVEAGTLPILRLA CCHHHHCHHHHHHHH	36.09	27717184
590	Ubiquitination	DPIRGLTKEQIDNLS CCCCCCCHHHHHHCC	53.30	27667366
601	Ubiquitination	DNLSTRSYEQDGVDS HHCCCCCHHHCCCCC	17.83	27667366

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RNF6_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RNF6_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RNF6_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LIMK1_MOUSE	Limk1	physical	16204183

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.