RN222_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN222_HUMAN
• UniProt AC: A6NCQ9
• Protein Name: RING finger protein 222
• Gene Name: RNF222
• Organism: Homo sapiens (Human).
• Sequence Length: 220
• Subcellular Localization: Membrane ; Single-pass membrane protein .
• Protein Sequence: MSEGESKDSSGSECPVCYEKFRDLEGASRTLSCGHVFCHDCLVKYLLSTRVDGQVQRTLVCPICRYVTFLSKKSSRWPSMLDKSSQTLAVPVGLPSVPPLDSLGHTNPLAASSPAWRPPPGQARPPGSPGQSAQLPLDLLPSLPRESQIFVISRHGMPLGEQDSVLPRRSLAELSEASLAPRSARAFCCRSRALLLITLIAVVAVVAAILPWVLLVRKQA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	EGESKDSSGSECPVC CCCCCCCCCCCCCCC	57.37	-
45	Phosphorylation	CHDCLVKYLLSTRVD EHHHHHHHHHHCCCC	12.85	27174698
48	Phosphorylation	CLVKYLLSTRVDGQV HHHHHHHHCCCCCCC	16.15	27174698
49	Phosphorylation	LVKYLLSTRVDGQVQ HHHHHHHCCCCCCCC	34.38	27174698
170	Phosphorylation	DSVLPRRSLAELSEA CCCCCHHHHHHHHHH	32.96	24850871
178	Phosphorylation	LAELSEASLAPRSAR HHHHHHHHCCCHHHH	22.47	24719451
198	Phosphorylation	SRALLLITLIAVVAV HHHHHHHHHHHHHHH	16.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN222_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN222_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN222_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RN222_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.