RN215_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RN215_HUMAN
• UniProt AC: Q9Y6U7
• Protein Name: RING finger protein 215
• Gene Name: RNF215
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MGPAARPALRSPPPPPPPPPSPLLLLLPLLPLWLGLAGPGAAADGSEPAAGAGRGGARAVRVDVRLPRQDALVLEGVRIGSEADPAPLLGGRLLLMDIVDAEQEAPVEGWIAVAYVGKEQAAQFHQENKGSGPQAYPKALVQQMRRALFLGASALLLLILNHNVVRELDISQLLLRPVIVLHYSSNVTKLLDALLQRTQATAEITSGESLSANIEWKLTLWTTCGLSKDGYGGWQDLVCLGGSRAQEQKPLQQLWNAILLVAMLLCTGLVVQAQRQASRQSQRELGGQVDLFKRRVVRRLASLKTRRCRLSRAAQGLPDPGAETCAVCLDYFCNKQWLRVLPCKHEFHRDCVDPWLMLQQTCPLCKFNVLGNRYSDD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	AARPALRSPPPPPPP CCCCCCCCCCCCCCC	42.48	16094384
21	Phosphorylation	PPPPPPPSPLLLLLP CCCCCCCCCHHHHHH	33.67	16094384
129	Ubiquitination	AQFHQENKGSGPQAY HHHHHHCCCCCCCCH	54.42	29967540
138	Ubiquitination	SGPQAYPKALVQQMR CCCCCHHHHHHHHHH	41.50	-
186	N-linked_Glycosylation	IVLHYSSNVTKLLDA EEEEECCCHHHHHHH	39.27	UniProtKB CARBOHYD
222	Phosphorylation	EWKLTLWTTCGLSKD EEEEEEEEECCCCCC	18.47	-
267	Phosphorylation	LVAMLLCTGLVVQAQ HHHHHHHHHHHHHHH	33.26	22210691
278	Phosphorylation	VQAQRQASRQSQREL HHHHHHHHHHHHHHH	23.63	22210691
324	Phosphorylation	LPDPGAETCAVCLDY CCCCCCCHHHHHHHH	12.77	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RN215_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RN215_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RN215_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RN215_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Quantitative phosphoproteome analysis using a dendrimer conjugationchemistry and tandem mass spectrometry.";
Tao W.A., Wollscheid B., O'Brien R., Eng J.K., Li X.-J.,Bodenmiller B., Watts J.D., Hood L., Aebersold R.;
Nat. Methods 2:591-598(2005).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-11 AND SER-21, AND MASSSPECTROMETRY.
PubMed: 16094384