RL8_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL8_RAT
• UniProt AC: P62919
• Protein Name: 60S ribosomal protein L8
• Gene Name: Rpl8
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 257
• Subcellular Localization: Cytoplasm .
• Protein Description: Component of the large ribosomal subunit..
• Protein Sequence: MGRVIRGQRKGAGSVFRAHVKHRKGAARLRAVDFAERHGYIKGIVKDIIHDPGRGAPLAKVVFRDPYRFKKRTELFIAAEGIHTGQFVYCGKKAQLNIGNVLPVGTMPEGTIVCCLEEKPGDRGKLARASGNYATVISHNPETKKTRVKLPSGSKKVISSANRAVVGVVAGGGRIDKPILKAGRAYHKYKAKRNCWPRVRGVAMNPVEHPFGGGNHQHIGKPSTIRRDAPAGRKVGLIAARRTGRLRGTKTVQEKEN

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	GQRKGAGSVFRAHVK CCCCCCCHHHHHHHC	19.97	25575281
42	Acetylation	AERHGYIKGIVKDII HHHHCCCHHHHHHHH	33.82	22902405
46	Acetylation	GYIKGIVKDIIHDPG CCCHHHHHHHHCCCC	41.09	22902405
60	Acetylation	GRGAPLAKVVFRDPY CCCCCCHHEEECCCC	46.76	22902405
130	Phosphorylation	RGKLARASGNYATVI CCHHHHHCCCEEEEE	23.24	23984901
144	Acetylation	ISHNPETKKTRVKLP EECCCCCCCEEEECC	50.95	22902405
177	Acetylation	AGGGRIDKPILKAGR ECCCCCCHHHHHCHH	31.42	22902405
216	Hydroxylation	HPFGGGNHQHIGKPS CCCCCCCCCCCCCCC	24.70	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL8_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
216	H	Hydroxylation	Hydroxylated on His-216 by RIOX1.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL8_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RL8_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.