RL27_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL27_RAT
• UniProt AC: P61354
• Protein Name: 60S ribosomal protein L27
• Gene Name: Rpl27
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 136
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm . Rough endoplasmic reticulum . Detected on cytosolic polysomes (By similarity). Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
• Protein Description: Component of the large ribosomal subunit (By similarity). Required for proper rRNA processing and maturation of 28S and 5.8S rRNAs (By similarity)..
• Protein Sequence: MGKFMKPGKVVLVLAGRYSGRKAVIVKNIDDGTSDRPYSHALVAGIDRYPRKVTAAMGKKKIAKRSKIKSFVKVYNYNHLMPTRYSVDIPLDKTVVNKDVFRDPALKRKARREAKVKFEERYKTGKNKWFFQKLRF

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Acetylation	-----MGKFMKPGKV -----CCCCCCCCEE	40.77	25786129
6	Acetylation	--MGKFMKPGKVVLV --CCCCCCCCEEEEE	54.47	72525257
27	Acetylation	GRKAVIVKNIDDGTS CCEEEEEEECCCCCC	36.74	22902405
33	Phosphorylation	VKNIDDGTSDRPYSH EEECCCCCCCCCCCE	34.15	27097102
34	Phosphorylation	KNIDDGTSDRPYSHA EECCCCCCCCCCCEE	36.83	27097102
38	Phosphorylation	DGTSDRPYSHALVAG CCCCCCCCCEEEECC	17.62	27097102
39	Phosphorylation	GTSDRPYSHALVAGI CCCCCCCCEEEECCH	12.64	27097102
85	Phosphorylation	NHLMPTRYSVDIPLD CCCCCCEEEEECCCC	18.61	28432305
86	Phosphorylation	HLMPTRYSVDIPLDK CCCCCEEEEECCCCC	15.26	28432305
93	Acetylation	SVDIPLDKTVVNKDV EEECCCCCCCCCCHH	51.40	22902405
93	Ubiquitination	SVDIPLDKTVVNKDV EEECCCCCCCCCCHH	51.40	-
94	Phosphorylation	VDIPLDKTVVNKDVF EECCCCCCCCCCHHH	29.38	23984901
98	Acetylation	LDKTVVNKDVFRDPA CCCCCCCCHHHCCHH	43.59	22902405
117	Acetylation	ARREAKVKFEERYKT HHHHHCCCHHHHHCC	46.48	22902405
126	Acetylation	EERYKTGKNKWFFQK HHHHCCCCCCCCEEC	61.66	22902405
128	Acetylation	RYKTGKNKWFFQKLR HHCCCCCCCCEECCC	49.19	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL27_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL27_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL27_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RL27_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.