RL27A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL27A_RAT
• UniProt AC: P18445
• Protein Name: 60S ribosomal protein L27a
• Gene Name: Rpl27a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 148
• Protein Sequence: MPSRLRKTRKLRGHVSHGHGRIGKHRKHPGGRGNAGGMHHHRINFDKYHPGYFGKVGMRHYHLKRNQSFCPTVNLDKLWTLVSEQTRVNAAKNKNGVAPIIDVVRSGYYKVLGKGKLPKQPVIVKAKFFSRRAEEKIKGVGGACVLVA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
39	Hydroxylation	RGNAGGMHHHRINFD CCCCCCCCCCCCCCC	19.51	-
47	Acetylation	HHRINFDKYHPGYFG CCCCCCCCCCCCCCC	41.12	22902405
55	Acetylation	YHPGYFGKVGMRHYH CCCCCCCCCCCCCCC	26.22	22902405
68	Phosphorylation	YHLKRNQSFCPTVNL CCCCCCCCCCCCCCH	32.15	27097102
72	Phosphorylation	RNQSFCPTVNLDKLW CCCCCCCCCCHHHHH	24.17	23984901
80	Phosphorylation	VNLDKLWTLVSEQTR CCHHHHHHHHCHHHH	27.93	23984901
83	Phosphorylation	DKLWTLVSEQTRVNA HHHHHHHCHHHHHHH	27.40	23984901
86	Phosphorylation	WTLVSEQTRVNAAKN HHHHCHHHHHHHHHH	32.31	23984901
106	Phosphorylation	PIIDVVRSGYYKVLG CHHHHHHHCCEEECC	21.38	23984901
108	Phosphorylation	IDVVRSGYYKVLGKG HHHHHHCCEEECCCC	11.02	23984901
109	Phosphorylation	DVVRSGYYKVLGKGK HHHHHCCEEECCCCC	9.72	23984901
110	Acetylation	VVRSGYYKVLGKGKL HHHHCCEEECCCCCC	23.62	-
125	Ubiquitination	PKQPVIVKAKFFSRR CCCCEEEEEEECCHH	34.43	-
127	Acetylation	QPVIVKAKFFSRRAE CCEEEEEEECCHHHH	41.02	22902405

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL27A_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
39	H	Hydroxylation	Hydroxylated on His-39 by MINA.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL27A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RL27A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.