RL23A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RL23A_RAT
• UniProt AC: P62752
• Protein Name: 60S ribosomal protein L23a
• Gene Name: Rpl23a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 156
• Protein Description: Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Binds a specific region on the 26S rRNA (By similarity). May promote p53/TP53 degradation possibly through the stimulation of MDM2-mediated TP53 polyubiquitination (By similarity)..
• Protein Sequence: MAPKAKKEAPAPPKAEAKAKALKAKKAVLKGVHSHKKKKIRTSPTFRRPKTLRLRRQPKYPRKSAPRRNKLDHYAIIKFPLTTESAMKKIEDNNTLVFIVDVKANKHQIKQAVKKLYDIDVAKVNTLIRPDGEKKAYVRLAPDYDALDVANKIGII

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Methylation	------MAPKAKKEA ------CCCHHCCCC	17.82	-
41	Citrullination	SHKKKKIRTSPTFRR HCCCCCCCCCCCCCC	37.72	-
41	Citrullination	SHKKKKIRTSPTFRR HCCCCCCCCCCCCCC	37.72	-
42	Phosphorylation	HKKKKIRTSPTFRRP CCCCCCCCCCCCCCC	42.40	25403869
43	Phosphorylation	KKKKIRTSPTFRRPK CCCCCCCCCCCCCCC	16.46	29779826
45	Phosphorylation	KKIRTSPTFRRPKTL CCCCCCCCCCCCCHH	29.55	21738781
70	Acetylation	KSAPRRNKLDHYAII CCCCCCCCCCEEEEE	54.18	59127719
115	Acetylation	QIKQAVKKLYDIDVA HHHHHHHHHHCCCHH	45.76	72611833
115	Ubiquitination	QIKQAVKKLYDIDVA HHHHHHHHHHCCCHH	45.76	-
115	Succinylation	QIKQAVKKLYDIDVA HHHHHHHHHHCCCHH	45.76	26843850
126	Phosphorylation	IDVAKVNTLIRPDGE CCHHHCCEEECCCCC	26.92	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RL23A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RL23A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RL23A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RL23A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.