RK4_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RK4_ARATH
• UniProt AC: O50061
• Protein Name: 50S ribosomal protein L4, chloroplastic
• Gene Name: RPL4
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 282
• Subcellular Localization: Plastid, chloroplast.
• Protein Description: This protein binds directly and specifically to 23S rRNA (By similarity). May play a role in plastid transcriptional regulation..
• Protein Sequence: MASSATAPNSLSFFSSSLFLSSSHQIPKTYISVSKLGSGRVSKPLSVSSQLATLPILSFEGEKVGETYLDLKAAPEDTARAVVHRAIVTDLNNKRRGTASTLTRGEVRGGGIKPYSQKKTGHARRGSQRTPLRPGGGVVFGPRPKDWSIKINRKEKKLAISTALSSAASAEGGAIVVEEFGEKFEKPKTKDFLAAMQRWGLDPKEKAMFLMIDVDENVAKSSRNIGTLRMLTPRTLNLFDILNADKLVLTPAAVEFLNARYGVDAVEEEDDDEDETEGSEEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
98	Phosphorylation	LNNKRRGTASTLTRG CCCCCCCCCCCCCCC	18.67	25561503
161	Phosphorylation	KEKKLAISTALSSAA HHHHHHHHHHHHHHH	11.30	29654922
165	Phosphorylation	LAISTALSSAASAEG HHHHHHHHHHHHCCC	18.57	26091701
166	Phosphorylation	AISTALSSAASAEGG HHHHHHHHHHHCCCC	28.80	26091701
261	Phosphorylation	VEFLNARYGVDAVEE HHHHHHHHCCCCCCC	21.06	29797451
276	Phosphorylation	EDDDEDETEGSEEA- CCCCCCCCCCCCCC-	58.95	23776212
279	Phosphorylation	DEDETEGSEEA---- CCCCCCCCCCC----	26.49	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RK4_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RK4_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RK4_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of RK4_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-279, AND MASSSPECTROMETRY.
PubMed: 19376835