| UniProt ID | RIR1_DROME | |
|---|---|---|
| UniProt AC | P48591 | |
| Protein Name | Ribonucleoside-diphosphate reductase large subunit | |
| Gene Name | RnrL | |
| Organism | Drosophila melanogaster (Fruit fly). | |
| Sequence Length | 812 | |
| Subcellular Localization | ||
| Protein Description | Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.. | |
| Protein Sequence | MLKNKSMKTSKLYVIKRDGRQEEVHFDKITSRIQKLCYNLNMDFVDPVTITLQVINGLYCGVTTQELDNLAAEIAAGLTCNHPDYAILAARIAVSNLHKETKKAFSDVFEDLYNHVNKETNQKVPLVSEFHYNVVKKNATRLNSSIIYDRDFGYNYFGFKTLERSYLLKRNGKIAERPQHMLMRVAIGIHGEDIDAAVETYNLLSERYFTHASPTLFAAATNRPQLSSCFLLTMTADSIEGIFKSVEQCAMISKSAGGIGLNVHCIRAKGTSICGTNGTSNGLVPMLRVFNNVARYVDQGGGKRPGAFAIYLEPWHSDVFEFLELKKNTGKEENRARDLFYALWIPDLFMKRVEANGDWSLMCPHKCPGLHDVWGDEFEKLYEKYEQEGRANRTVKAQSLWFAIIEAQVETGNPYMLFKDACNRKSNQQNVGTIKCSNLCTEIVEYSAPDEIAVCNLASIALNMFVTPEKTYDFKKLKEVTKIVTKNLNKIIDINYYPLPEARKSNLRHRPVGIGIQGFADALILMRFPYESEEAGLLNQQIFETIYYGALEASCELAQTEGPYETYEGSPVSKGILQYDMWDKVPTNLWDWQKLKESIRMHGVRNSLLVAPMPTASTAQIMGNNESFEPYTTNIYTRRVLSGEFQVVNHHLLRDLTELDLWDDDMKNQIISSRGSIQNIETIPPKVRDLYKTVWEISVKSTIKMAADRGAFIDQSQSFNIHVAEPNYGKLTSIHFYSWKAGLKTGMYYLRTKPAANAIQFTVNKKQGAVSMNGQNGTAEGSPQKYEEDRERKMADMVCSLENKDACMSCGS | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Acetylation | NKSMKTSKLYVIKRD CCCCCCCEEEEEEEC | 49.41 | 21791702 | |
| 28 | Acetylation | QEEVHFDKITSRIQK CEEECHHHHHHHHHH | 47.11 | 21791702 | |
| 642 | Phosphorylation | IYTRRVLSGEFQVVN EEECCCCCCCCEEEC | 33.16 | 19429919 | |
| 762 | Phosphorylation | AANAIQFTVNKKQGA CCCEEEEEEECCCCC | 13.54 | 21082442 | |
| 771 | Phosphorylation | NKKQGAVSMNGQNGT ECCCCCEEECCCCCC | 13.14 | 23607784 | |
| 778 | Phosphorylation | SMNGQNGTAEGSPQK EECCCCCCCCCCHHH | 29.14 | 23607784 | |
| 782 | Phosphorylation | QNGTAEGSPQKYEED CCCCCCCCHHHHHHH | 18.70 | 19429919 | |
| 786 | Phosphorylation | AEGSPQKYEEDRERK CCCCHHHHHHHHHHH | 21.21 | 22817900 | |
| 800 | Phosphorylation | KMADMVCSLENKDAC HHHHHHHHHCCHHHH | 27.58 | 22817900 | |
| 812 | Phosphorylation | DACMSCGS------- HHHHCCCC------- | 41.18 | 18327897 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RIR1_DROME !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RIR1_DROME !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RIR1_DROME !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RIR1_DROME !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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| Phosphorylation | |
| Reference | PubMed |
| "Phosphoproteome analysis of Drosophila melanogaster embryos."; Zhai B., Villen J., Beausoleil S.A., Mintseris J., Gygi S.P.; J. Proteome Res. 7:1675-1682(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-778; SER-782 ANDTYR-786, AND MASS SPECTROMETRY. | |
