dbPTM

RIPL1_RAT - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIPL1_RAT
UniProt AC	D3ZUQ0
Protein Name	RILP-like protein 1
Gene Name	Rilpl1
Organism	Rattus norvegicus (Rat).
Sequence Length	406
Subcellular Localization	Cytoplasm, cytosol . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cell projection, cilium.
Protein Description	Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia (By similarity). Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution..
Protein Sequence	MEEPLGSPPAALSALEKNVAELTVMDVYDIASLVGHEFERVIDQHGCEAIARLMPKVVRVLEILEVLVSRHHVAPELDELRLELDRLRVERMDRIEKERKHQKELELVEDVWRGEAQDLLSQIAQLQEENKQLMTNLNHKDVGFSEEELQKHEGMSERERQVMKRLKEVVDKQRDEIRAKDRELVLKNEDVEALQQQQTRLMKINHDLRHRVTVVEAQGKALIEQKVELEADLQTKEQEMGSLRAELGKLRERLQGEHSQNGEEEEAEIPPQPDGEESISDAEKAALDLKDPNRPRFTLQELRDVLHERNELKSKVFLLQEELAYYKSEEIEEENRIPQPPPITHPRTSPQPESGIKRLFSFFSRDKRRLANTQRPTHIHESFGQWAITHRDDGYTEQGQEALQHL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MEEPLGSPPAALSA -CCCCCCCCHHHHHH	35.08	27097102
13	Phosphorylation	GSPPAALSALEKNVA CCCHHHHHHHHHCCH	26.53	23984901
47	S-nitrosocysteine	RVIDQHGCEAIARLM HHHHHHHHHHHHHHH	2.75	-
47	S-nitrosylation	RVIDQHGCEAIARLM HHHHHHHHHHHHHHH	2.75	19607794
145	Phosphorylation	NHKDVGFSEEELQKH CCCCCCCCHHHHHHC	37.86	23984901
203	Ubiquitination	QQQTRLMKINHDLRH HHHHHHHHHCHHHHH	44.97	-
242	Phosphorylation	TKEQEMGSLRAELGK HHHHHHHHHHHHHHH	17.24	28432305
259	Phosphorylation	ERLQGEHSQNGEEEE HHHCCCCCCCCCHHC	22.49	-
348	Phosphorylation	PPITHPRTSPQPESG CCCCCCCCCCCCCCH	49.57	30181290
349	Phosphorylation	PITHPRTSPQPESGI CCCCCCCCCCCCCHH	23.87	30181290
361	Phosphorylation	SGIKRLFSFFSRDKR CHHHHHHHHHCHHHH	29.94	23984901

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RIPL1_RAT !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RIPL1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIPL1_RAT !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
G3P_RAT	Gapdh	physical	19607794

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIPL1_RAT

Related Literatures of Post-Translational Modification

S-nitrosylation
Reference	PubMed
"GOSPEL: a neuroprotective protein that binds to GAPDH upon S-nitrosylation."; Sen N., Hara M.R., Ahmad A.S., Cascio M.B., Kamiya A., Ehmsen J.T.,Agrawal N., Hester L., Dore S., Snyder S.H., Sawa A.; Neuron 63:81-91(2009). Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, INTERACTION WITHGAPDH, S-NITROSYLATION AT CYS-47, AND MUTAGENESIS OF CYS-47.	19607794 [Abstract]