RIOK3_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RIOK3_MOUSE
• UniProt AC: Q9DBU3
• Protein Name: Serine/threonine-protein kinase RIO3
• Gene Name: Riok3
• Organism: Mus musculus (Mouse).
• Sequence Length: 519
• Subcellular Localization: Cytoplasm .
• Protein Description: Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. May act as an adapter protein essential for the recruitment of TBK1 to IRF3. Phosphorylates IFIH1 on 'Ser-828' interfering with IFIH1 filament assembly on long dsRNA and resulting in attenuated IFIH1-signaling. Can inhibit CASP10 isoform 7-mediated activation of the NF-kappaB signaling pathway. May play a role in the biogenesis of the 40S ribosomal subunit. Involved in the processing of 21S pre-rRNA to the mature 18S rRNA..
• Protein Sequence: MDLVGVSSPEPGPAAAWGPSKCPWATPQNTVSCSLTEVMSEELAKELQLEEEAAAFPEVVVAEGPFISGENIDTSSDLMLAQMLQMEFDREYDAQLRREEKKFNGDSKVSISFENYRKVHPFEDSDSSEDEVDWQDTRDDPYRPAKPIPTPKKGFIGKGKDITTKHDEVVCGRKNTARMENFAPGFQVGDGIGMDLKLSNHVFNALKQHAYSEERRSARLHEKKEHSTAEKAVDPKTRLLMYKMVNSGMLETITGCISTGKESVVFHAYGGSLEDEKEDGKAIPTECAIKVFKTTLNEFKNRDKYIKDDFRFKDRFSKLNPRKIIRMWAEKEMHNLTRMQKAGIPCPTVVLLKKHILVMSFIGHDQVPAPKLKEVKLSNEEMKDAYYQTLHLMQQLYNECTLVHADLSEYNMLWHAGKVWLIDVSQSVEPTHPHGLEFLFRDCRNVSQFFQKGGVTEALNERELFNAVSGLNISADNEADFLAEIEALEKMNEDHIQKNGRKAASFLKDDGSPPVLSAD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MDLVGVSSPEPGPA -CCCCCCCCCCCCCC	33.96	25266776
8	Phosphorylation	MDLVGVSSPEPGPAA CCCCCCCCCCCCCCC	30.76	25266776
20	Phosphorylation	PAAAWGPSKCPWATP CCCCCCCCCCCCCCC	42.84	26643407
108	Ubiquitination	KKFNGDSKVSISFEN HHHCCCCCEEEEEEC	44.75	-
110	Phosphorylation	FNGDSKVSISFENYR HCCCCCEEEEEECCE	19.09	29514104
112	Phosphorylation	GDSKVSISFENYRKV CCCCEEEEEECCEEE	20.99	26060331
116	Phosphorylation	VSISFENYRKVHPFE EEEEEECCEEEECCC	12.47	29514104
125	Phosphorylation	KVHPFEDSDSSEDEV EEECCCCCCCCCCCC	31.99	27087446
127	Phosphorylation	HPFEDSDSSEDEVDW ECCCCCCCCCCCCCC	39.31	27087446
128	Phosphorylation	PFEDSDSSEDEVDWQ CCCCCCCCCCCCCCC	54.80	27087446
137	Phosphorylation	DEVDWQDTRDDPYRP CCCCCCCCCCCCCCC	22.39	25367039
142	Phosphorylation	QDTRDDPYRPAKPIP CCCCCCCCCCCCCCC	35.90	25367039
150	Phosphorylation	RPAKPIPTPKKGFIG CCCCCCCCCCCCCCC	48.75	25367039
165	Ubiquitination	KGKDITTKHDEVVCG CCCCCCCCCCEEECC	40.17	-
197	Ubiquitination	DGIGMDLKLSNHVFN CCCCCCHHHHHHHHH	45.68	-
207	Ubiquitination	NHVFNALKQHAYSEE HHHHHHHHHHCCCHH	37.31	-
212	Phosphorylation	ALKQHAYSEERRSAR HHHHHCCCHHHHHHH	33.49	29899451
217	Phosphorylation	AYSEERRSARLHEKK CCCHHHHHHHHHHHH	24.78	29899451
242	Phosphorylation	PKTRLLMYKMVNSGM HHHHHHHHHHHHCCC	8.90	22871156
300	Ubiquitination	KTTLNEFKNRDKYIK HHHHHHHHCCCCCCC	44.91	-
505	Phosphorylation	KNGRKAASFLKDDGS HHCHHHHHHHCCCCC	35.65	28833060
512	Phosphorylation	SFLKDDGSPPVLSAD HHHCCCCCCCCCCCC	32.78	26824392
517	Phosphorylation	DGSPPVLSAD----- CCCCCCCCCC-----	30.53	25619855

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RIOK3_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RIOK3_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RIOK3_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RIOK3_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.