RIMB2_MOUSE - dbPTM
RIMB2_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RIMB2_MOUSE
UniProt AC Q80U40
Protein Name RIMS-binding protein 2
Gene Name Rimbp2
Organism Mus musculus (Mouse).
Sequence Length 1072
Subcellular Localization Cell membrane. Cell junction, synapse. Synaptic plasma membrane..
Protein Description Plays a role in the synaptic transmission as bifunctional linker that interacts simultaneously with RIMS1, RIMS2, CACNA1D and CACNA1B..
Protein Sequence MREAAERRQQLELEHEQALAFLNAKQQEIQLLQQAQVEAKKEHEGAVQLLESKVRELEEKCRVQSEQFNLLSRDLEKFRQHTGSIDLLGSSSVALLDVPLAPGKPFPQYMNGLATSIHKGHEGPTGHYSVIGDYIPLSGDKLESPCVKPSFLLRSSSPRCRFESEMDNDRNSNNSKQSSSGKVHLCVARYSYNPFDGPNENPEAELPLTAGKYLYVYGDMDEDGFYEGELLDGQRGLVPSNFVDFIQDNESRLAGTLGSEQDQNFLNHSGISLERDSILHLHSPTQVDSGITDNGGGTLDVNIDDIGEDTVPYPRKITLIKQLAKSVIVGWEPPAVPPGWGTVSSYNVLVDKETRMSLALGRRTKALIEKLNTAACTYRISVQCVTSRGNSDELQCTLLVGKDVVVAPSQLRVDNITQISAQLSWLPTNSNYSHIIFLNEEELDIVKAARYKYQFFNLRPNMAYKVKVLAQPHQMPWQLPLEQREKKEACVEFSTLPAGPPAPPQDVTVHAGATAASVQVSWKPPALTPTGLSNGANVTGYGVYAKGQRVAEVIAPTADGTAVELIRLRSLEAKAVSVRTLSVQGESMDSALAAIPPDLLVPPAPHPRTAPPPKPLASDMDTKDQHLGPHVKVDESWEQSRSPGPAHGHMLEPPDMHSAGPGRRSPSPSRILPQPQGAPVSTTVAKAMAREAAQRVAESNRLEKRSLFLEQSSAGQYTNSDEEDGYASPEVKRRGTSVDDFLKGSELGKQPHCCHGDEYHTESSRGSDLSDIMEEDEEELYSEMQLEDGGRRRPSGTSHNALKILGNSTLMGRADRMEHVSRRYSHSGGGSHRHRPAMAPSIDEYTGRDHLSPDFYDESETDPGAEELPARIFVALFDYDPLTMSPNPDAAEEELPFKEGQIIKVYGDKDADGFYRGETCARLGLIPCNMVSEIHADDEEMMDQLLRQGFLPLNTPVEKIERSRRSGRGHSVPTRRMVALYDYDPRESSPNVDVEAELPFCTGDIITVFGEIDEDGFYYGELNGQKGLVPSNFLEEVPDDVEVHLSDAPPHYSHDPPMRSKAKRKKSVHFTP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
269PhosphorylationDQNFLNHSGISLERD
HHHHHHCCCCCCCCC		36.4329899451
272PhosphorylationFLNHSGISLERDSIL
HHHCCCCCCCCCCEE		27.9225159016
283PhosphorylationDSILHLHSPTQVDSG
CCEEECCCCCEECCC		35.6829899451
381PhosphorylationAACTYRISVQCVTSR
CCCCEEEEEEEEECC		9.3519367708
667PhosphorylationGPGRRSPSPSRILPQ
CCCCCCCCHHHCCCC		36.4329899451
669PhosphorylationGRRSPSPSRILPQPQ
CCCCCCHHHCCCCCC		35.9729899451
681O-linked_GlycosylationQPQGAPVSTTVAKAM
CCCCCCCHHHHHHHH		19.8022517741
683O-linked_GlycosylationQGAPVSTTVAKAMAR
CCCCCHHHHHHHHHH		15.8022517741
706PhosphorylationSNRLEKRSLFLEQSS
HCCHHHHHHHEECCC		34.2429899451
712PhosphorylationRSLFLEQSSAGQYTN
HHHHEECCCCCCCCC		16.8729899451
713PhosphorylationSLFLEQSSAGQYTNS
HHHEECCCCCCCCCC		35.7929899451
717PhosphorylationEQSSAGQYTNSDEED
ECCCCCCCCCCCCCC		13.6329899451
718PhosphorylationQSSAGQYTNSDEEDG
CCCCCCCCCCCCCCC		21.9929899451
720PhosphorylationSAGQYTNSDEEDGYA
CCCCCCCCCCCCCCC		38.3025521595
726PhosphorylationNSDEEDGYASPEVKR
CCCCCCCCCCHHHHH		19.0724759943
728PhosphorylationDEEDGYASPEVKRRG
CCCCCCCCHHHHHCC		17.0725521595
736PhosphorylationPEVKRRGTSVDDFLK
HHHHHCCCCHHHHHC		24.6229899451
737PhosphorylationEVKRRGTSVDDFLKG
HHHHCCCCHHHHHCC		26.7729899451
770PhosphorylationSSRGSDLSDIMEEDE
CCCCCCHHHHCHHCH		30.0429899451
795PhosphorylationDGGRRRPSGTSHNAL
CCCCCCCCCCCHHHH		53.5529899451
797PhosphorylationGRRRPSGTSHNALKI
CCCCCCCCCHHHHHH		31.0229899451
798PhosphorylationRRRPSGTSHNALKIL
CCCCCCCCHHHHHHH		20.4729899451
841PhosphorylationHRPAMAPSIDEYTGR
CCCCCCCCCHHHCCC		32.8829899451
845PhosphorylationMAPSIDEYTGRDHLS
CCCCCHHHCCCCCCC		15.6729899451
846PhosphorylationAPSIDEYTGRDHLSP
CCCCHHHCCCCCCCC		24.5629899451
852PhosphorylationYTGRDHLSPDFYDES
HCCCCCCCCCCCCCC		21.0025521595
856PhosphorylationDHLSPDFYDESETDP
CCCCCCCCCCCCCCC		26.6119060867
859PhosphorylationSPDFYDESETDPGAE
CCCCCCCCCCCCCHH		42.7919060867
861PhosphorylationDFYDESETDPGAEEL
CCCCCCCCCCCHHHC		57.6919060867
955PhosphorylationQGFLPLNTPVEKIER
CCCCCCCCCHHHHHH		36.0722324799
966PhosphorylationKIERSRRSGRGHSVP
HHHHHHHCCCCCCCC		31.5629899451
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RIMB2_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RIMB2_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RIMB2_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RIMB2_MOUSE !!
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RIMB2_MOUSE

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Qualitative and quantitative analyses of protein phosphorylation innaive and stimulated mouse synaptosomal preparations.";
Munton R.P., Tweedie-Cullen R., Livingstone-Zatchej M., Weinandy F.,Waidelich M., Longo D., Gehrig P., Potthast F., Rutishauser D.,Gerrits B., Panse C., Schlapbach R., Mansuy I.M.;
Mol. Cell. Proteomics 6:283-293(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-852, AND MASSSPECTROMETRY.

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