dbPTM

RICTR_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RICTR_MOUSE
UniProt AC	Q6QI06
Protein Name	Rapamycin-insensitive companion of mTOR
Gene Name	Rictor {ECO:0000250\|UniProtKB:Q6R327}
Organism	Mus musculus (Mouse).
Sequence Length	1708
Subcellular Localization
Protein Description	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Plays an essential role in embryonic growth and development..
Protein Sequence	MAAIGRGRSLKNLRIRGRNDSGEENVPLDLTREPSDNLREILQNVAKLQGVSNMRKLGHLNNFTKLLCDIGHSEEKLGFNYEDIIICLRLALLNEAKEVRAAGLRALRYLIQDSSILQKVLKLKVDYLIARCIDIQQSNEVERTQALRLVRKMITVNASLFPSSVANSLIAVGNDGLQERDRMVRACIAIICELALQNPEVVALRGGLNTILKNVIDCQLSRINEALITTILHLLNHPKTRQYVRADVELERILAPYTDFHYRHSPDTAEGQLKEDREARFLASKMGIIATFRSWAGIINLCKPGNSGIQSLIGVLCIPNMEIRRGLLEVLYDIFRLPLPVVTDEFIEALLSVDPGRFQDSWRLSDGFVAAEAKTILPHRARSRPDLMDNYLALILSAFIRNGLLEGLVEVITNSDDHISVRATILLGELLHMANTILPHSHSHHLHCLPTLMNMAASFDIPKEKRLRASAALNCLNRFHEMKKRGPKPYSLHLDHIIQKAIATHHKRDQYLRVQKDIFVLKDTEEALLINLRDSQVLQHKENLDWDWNLIGTILKWPNVNLRNYKDEQLHRFVRRLLYFYKPSSKLYASLDLDLAKSKQLTVVGCQFTEFLLESEEDGQGYLEDLVKDIVQWLNASSGVKPERSLQNNGLLTTLSQHYFLFIGTLSCHPHGVKMLEKCSVFQCLLNLCSLKNQDHLIKLTVSSLDYSRDGLARVILSKILTAATDACRLYATKHLRVLLRANVEFFNNWGIELLVTQLHDKNKTISSEALDILDEACEDKANLHALIQMKPALSHLGDKGLLLLLRFLSIPKGFSYLNERGYVAKQLEKWHKEYNSKYVDLIEEQLNEALTTYRKPIDGDNYVRRSNQRLQRPHVYLPVHLYGQLVHHKTGCHLLEVQSIITELCHNVRTPDLDKWEDIKKLKASLWALGNIGSSNWGLNLLQEENVIPDILKLAKQCEVLSIRGTCVYVLGLIAKTKQGCDILKCHSWDSVRHSRKHLWPVVPDDVEQLCNELSSVPSTLSLNSESTSSRHNSESESAPSSMFMLEDDRFGSTSTSTFFLDINEDAEPAFYDRPGPIKDKNSFPFFGSSKLVKNRILNSLTLPTKKHRSSSDPKGGKLSSENKTSNRRIRTLTEPSVDLNHSEDFTSSSAQKSLQLEPSFVGNKHLEDAGSTPSIGENDLKFPKSFGTETHRENTSRERLVVEGSASSHIKIRSQSFNTDTTTSGISSMSSSPSRETVAVDPTAMDTDCGSLSTVVSTKTVKTSHYLTPQSNHLSLSKSNSVSLVPPGSSHTLPRRAQSLKAPSIATIKSLADCNFSYTSSRDAFGYATLKRLQQQRMHPSLSHSEALASPAKDVLFTDTITMKANSFESRLTPSRFMKALSYASLDKEDLLSPINHNTLQRSSSVRSMVSSATYGGSDDYIGLALPVDINDIFQIKDVPYFQSKHVPPPDDRGARMFSHDGAGLSSGAGGLVKNSFHLLRQQMSLTEIMNSVHSDASLFLESTEDTGLQEHTDDNCLYCVCIELLGFQPSNQLSSICSHSDLQDIPYSDWCEQTIHNPLEVVPSKFSGISGCSDGASQEEGSASSTKSTELLLGVKTIPDDTPMCRILLRKEVLRLVVNLSSSVSTKCHETGLLTIKEKYPQTFDDICLYSEVSHLLSHCTFRLQCRRFIQELFQDVQFLQMHEEAEAVLAIPPIQPIVDESAES

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
21	Phosphorylation	RIRGRNDSGEENVPL EEECCCCCCCCCCCC	52.21	27087446
31	Phosphorylation	ENVPLDLTREPSDNL CCCCCCCCCCCCHHH	32.43	25619855
35	Phosphorylation	LDLTREPSDNLREIL CCCCCCCCHHHHHHH	34.08	25619855
258	Phosphorylation	ERILAPYTDFHYRHS HHHCCCCCCCCCCCC	31.00	23984901
262	Phosphorylation	APYTDFHYRHSPDTA CCCCCCCCCCCCCCC	15.26	23984901
265	Phosphorylation	TDFHYRHSPDTAEGQ CCCCCCCCCCCCCCC	18.57	23984901
268	Phosphorylation	HYRHSPDTAEGQLKE CCCCCCCCCCCCCCH	29.96	23984901
863	Phosphorylation	KPIDGDNYVRRSNQR CCCCCCCHHHCCCCC	10.48	29514104
1035	Phosphorylation	STSSRHNSESESAPS CCCCCCCCCCCCCCC	36.05	25338131
1054	Phosphorylation	LEDDRFGSTSTSTFF ECCCCCCCCCCEEEE	19.24	22871156
1057	Phosphorylation	DRFGSTSTSTFFLDI CCCCCCCCEEEEEEC	31.69	22871156
1059	Phosphorylation	FGSTSTSTFFLDINE CCCCCCEEEEEECCC	20.63	22871156
1084	Phosphorylation	GPIKDKNSFPFFGSS CCCCCCCCCCCCCCC	39.78	23684622
1090	Phosphorylation	NSFPFFGSSKLVKNR CCCCCCCCCHHHHHH	21.10	29472430
1091	Phosphorylation	SFPFFGSSKLVKNRI CCCCCCCCHHHHHHH	30.32	29472430
1101	Phosphorylation	VKNRILNSLTLPTKK HHHHHHHHCCCCCCC	21.20	26824392
1103	Phosphorylation	NRILNSLTLPTKKHR HHHHHHCCCCCCCCC	30.43	27600695
1106	Phosphorylation	LNSLTLPTKKHRSSS HHHCCCCCCCCCCCC	56.70	28066266
1113	Phosphorylation	TKKHRSSSDPKGGKL CCCCCCCCCCCCCCC	60.21	25266776
1121	Phosphorylation	DPKGGKLSSENKTSN CCCCCCCCCCCCCCC	38.81	29109428
1122	Phosphorylation	PKGGKLSSENKTSNR CCCCCCCCCCCCCCC	56.47	29109428
1133	Phosphorylation	TSNRRIRTLTEPSVD CCCCCEEECCCCCCC	35.34	25619855
1135	Phosphorylation	NRRIRTLTEPSVDLN CCCEEECCCCCCCCC	45.28	25619855
1138	Phosphorylation	IRTLTEPSVDLNHSE EEECCCCCCCCCCCC	23.25	25619855
1144	Phosphorylation	PSVDLNHSEDFTSSS CCCCCCCCCCCCCCH	37.48	25619855
1148	Phosphorylation	LNHSEDFTSSSAQKS CCCCCCCCCCHHHHH	39.77	25619855
1149	Phosphorylation	NHSEDFTSSSAQKSL CCCCCCCCCHHHHHH	23.45	25619855
1150	Phosphorylation	HSEDFTSSSAQKSLQ CCCCCCCCHHHHHHC	27.00	25619855
1151	Phosphorylation	SEDFTSSSAQKSLQL CCCCCCCHHHHHHCC	34.19	25619855
1155	Phosphorylation	TSSSAQKSLQLEPSF CCCHHHHHHCCCCCC	14.85	25263469
1161	Phosphorylation	KSLQLEPSFVGNKHL HHHCCCCCCCCCHHH	24.16	26824392
1173	Phosphorylation	KHLEDAGSTPSIGEN HHHHHCCCCCCCCCC	38.57	27087446
1174	Phosphorylation	HLEDAGSTPSIGEND HHHHCCCCCCCCCCC	21.82	27087446
1176	Phosphorylation	EDAGSTPSIGENDLK HHCCCCCCCCCCCCC	43.23	27087446
1187	Phosphorylation	NDLKFPKSFGTETHR CCCCCCHHHCCCCCC	29.19	26824392
1190	Phosphorylation	KFPKSFGTETHRENT CCCHHHCCCCCCCCC	35.38	25338131
1192	Phosphorylation	PKSFGTETHRENTSR CHHHCCCCCCCCCCC	26.52	25777480
1197	Phosphorylation	TETHRENTSRERLVV CCCCCCCCCCCEEEE	25.14	23684622
1198	Phosphorylation	ETHRENTSRERLVVE CCCCCCCCCCEEEEE	43.66	26824392
1207	Phosphorylation	ERLVVEGSASSHIKI CEEEEECCCCCCEEE	16.09	24719451
1216	Phosphorylation	SSHIKIRSQSFNTDT CCCEEEEEECCCCCC	33.38	25619855
1218	Phosphorylation	HIKIRSQSFNTDTTT CEEEEEECCCCCCCC	23.01	25619855
1221	Phosphorylation	IRSQSFNTDTTTSGI EEEECCCCCCCCCCC	32.48	25619855
1224	Phosphorylation	QSFNTDTTTSGISSM ECCCCCCCCCCCCCC	23.05	25619855
1229	Phosphorylation	DTTTSGISSMSSSPS CCCCCCCCCCCCCCC	24.42	25619855
1230	Phosphorylation	TTTSGISSMSSSPSR CCCCCCCCCCCCCCC	22.29	25619855
1232	Phosphorylation	TSGISSMSSSPSRET CCCCCCCCCCCCCCE	29.61	28066266
1233	Phosphorylation	SGISSMSSSPSRETV CCCCCCCCCCCCCEE	37.31	25619855
1234	Phosphorylation	GISSMSSSPSRETVA CCCCCCCCCCCCEEE	21.42	25619855
1236	Phosphorylation	SSMSSSPSRETVAVD CCCCCCCCCCEEEEC	44.70	28066266
1268	Phosphorylation	KTVKTSHYLTPQSNH CEEECCCCCCCCCCC	16.43	29514104
1277	Phosphorylation	TPQSNHLSLSKSNSV CCCCCCCCCCCCCCC	24.05	25266776
1281	Phosphorylation	NHLSLSKSNSVSLVP CCCCCCCCCCCEECC	30.84	27149854
1283	Phosphorylation	LSLSKSNSVSLVPPG CCCCCCCCCEECCCC	21.85	26824392
1285	Phosphorylation	LSKSNSVSLVPPGSS CCCCCCCEECCCCCC	24.38	29472430
1291	Phosphorylation	VSLVPPGSSHTLPRR CEECCCCCCCCCCHH	25.39	21454597
1292	Phosphorylation	SLVPPGSSHTLPRRA EECCCCCCCCCCHHH	26.80	25777480
1294	Phosphorylation	VPPGSSHTLPRRAQS CCCCCCCCCCHHHHH	40.17	26239621
1301	Phosphorylation	TLPRRAQSLKAPSIA CCCHHHHHCCCCCHH	30.74	26824392
1303	Ubiquitination	PRRAQSLKAPSIATI CHHHHHCCCCCHHHH	64.60	27667366
1306	Phosphorylation	AQSLKAPSIATIKSL HHHCCCCCHHHHHHH	29.70	25266776
1311	Acetylation	APSIATIKSLADCNF CCCHHHHHHHCCCCC	34.75	7927341
1312	Phosphorylation	PSIATIKSLADCNFS CCHHHHHHHCCCCCC	25.57	26643407
1319	Phosphorylation	SLADCNFSYTSSRDA HHCCCCCCCCCCCCH	17.32	28066266
1320	Phosphorylation	LADCNFSYTSSRDAF HCCCCCCCCCCCCHH	13.40	28066266
1321	Phosphorylation	ADCNFSYTSSRDAFG CCCCCCCCCCCCHHH	21.01	26643407
1322	Phosphorylation	DCNFSYTSSRDAFGY CCCCCCCCCCCHHHH	18.36	26643407
1323	Phosphorylation	CNFSYTSSRDAFGYA CCCCCCCCCCHHHHH	26.78	26643407
1329	Phosphorylation	SSRDAFGYATLKRLQ CCCCHHHHHHHHHHH	7.03	26643407
1331	Phosphorylation	RDAFGYATLKRLQQQ CCHHHHHHHHHHHHH	25.07	25521595
1343	Phosphorylation	QQQRMHPSLSHSEAL HHHCCCCCCCHHHHH	28.03	18846507
1345	Phosphorylation	QRMHPSLSHSEALAS HCCCCCCCHHHHHHC	29.33	26643407
1347	Phosphorylation	MHPSLSHSEALASPA CCCCCCHHHHHHCCC	22.61	18846507
1352	Phosphorylation	SHSEALASPAKDVLF CHHHHHHCCCCCEEE	26.66	24899341
1369	Phosphorylation	TITMKANSFESRLTP CEEEECCCHHCCCCH	34.94	26643407
1372	Phosphorylation	MKANSFESRLTPSRF EECCCHHCCCCHHHH	30.49	26643407
1375	Phosphorylation	NSFESRLTPSRFMKA CCHHCCCCHHHHHHH	20.36	26643407
1381	Ubiquitination	LTPSRFMKALSYASL CCHHHHHHHHHHHCC	43.39	22790023
1384	Phosphorylation	SRFMKALSYASLDKE HHHHHHHHHHCCCHH	24.42	27087446
1385	Phosphorylation	RFMKALSYASLDKED HHHHHHHHHCCCHHH	10.89	21082442
1387	Phosphorylation	MKALSYASLDKEDLL HHHHHHHCCCHHHHC	28.94	27087446
1390	Ubiquitination	LSYASLDKEDLLSPI HHHHCCCHHHHCCCC	59.42	22790023
1395	Phosphorylation	LDKEDLLSPINHNTL CCHHHHCCCCCCCCC	30.91	23984901
1401	Phosphorylation	LSPINHNTLQRSSSV CCCCCCCCCCCCHHH	19.40	25293948
1405	Phosphorylation	NHNTLQRSSSVRSMV CCCCCCCCHHHHHHH	17.63	26643407
1406	Phosphorylation	HNTLQRSSSVRSMVS CCCCCCCHHHHHHHH	34.73	26643407
1407	Phosphorylation	NTLQRSSSVRSMVSS CCCCCCHHHHHHHHH	23.85	26643407
1410	Phosphorylation	QRSSSVRSMVSSATY CCCHHHHHHHHHCCC	22.75	26643407
1413	Phosphorylation	SSVRSMVSSATYGGS HHHHHHHHHCCCCCC	12.96	26643407
1414	Phosphorylation	SVRSMVSSATYGGSD HHHHHHHHCCCCCCC	17.14	26643407
1416	Phosphorylation	RSMVSSATYGGSDDY HHHHHHCCCCCCCCC	25.33	26643407
1417	Phosphorylation	SMVSSATYGGSDDYI HHHHHCCCCCCCCCE	21.14	26643407
1420	Phosphorylation	SSATYGGSDDYIGLA HHCCCCCCCCCEEEE	23.97	26643407
1423	Phosphorylation	TYGGSDDYIGLALPV CCCCCCCCEEEEEEC	11.24	26643407
1461	Phosphorylation	DRGARMFSHDGAGLS CCCCCCCCCCCCCCC	16.01	22817900
1468	Phosphorylation	SHDGAGLSSGAGGLV CCCCCCCCCCCCHHH	26.30	26824392
1469	Phosphorylation	HDGAGLSSGAGGLVK CCCCCCCCCCCHHHH	37.39	29472430
1478	Phosphorylation	AGGLVKNSFHLLRQQ CCHHHHHHHHHHHHC	14.34	22817900
1570	Phosphorylation	EVVPSKFSGISGCSD EECCCCCCCCCCCCC	38.67	29472430
1573	Phosphorylation	PSKFSGISGCSDGAS CCCCCCCCCCCCCCC	36.95	26643407
1576	Phosphorylation	FSGISGCSDGASQEE CCCCCCCCCCCCCCC	42.47	27087446
1580	Phosphorylation	SGCSDGASQEEGSAS CCCCCCCCCCCCCCC	43.59	27087446
1585	Phosphorylation	GASQEEGSASSTKST CCCCCCCCCCCCCCC	28.40	21183079
1587	Phosphorylation	SQEEGSASSTKSTEL CCCCCCCCCCCCCHH	39.99	28066266
1588	Phosphorylation	QEEGSASSTKSTELL CCCCCCCCCCCCHHE	39.30	28066266
1589	Phosphorylation	EEGSASSTKSTELLL CCCCCCCCCCCHHEE	26.90	28066266
1591	Phosphorylation	GSASSTKSTELLLGV CCCCCCCCCHHEEEC	27.48	25521595
1592	Phosphorylation	SASSTKSTELLLGVK CCCCCCCCHHEEECE	32.01	25521595
1626	Phosphorylation	LVVNLSSSVSTKCHE HHHHCCCCCCCCCCC	19.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
1135	T	Phosphorylation	Kinase	RPS6KB1	Q8BSK8	Uniprot

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
1135	T	Phosphorylation		-
Phosphorylated at Thr-1135 by RPS6KB1; phosphorylation of RICTOR inhibits mTORC2 and AKT1 signaling (By similarity).

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RICTR_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
MTOR_MOUSE	Mtor	physical	20801936
MTOR_MOUSE	Mtor	physical	18664580

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RICTR_MOUSE

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Solid tumor proteome and phosphoproteome analysis by high resolutionmass spectrometry."; Zanivan S., Gnad F., Wickstroem S.A., Geiger T., Macek B., Cox J.,Faessler R., Mann M.; J. Proteome Res. 7:5314-5326(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-21 AND SER-1176, ANDMASS SPECTROMETRY.	19367708 [Abstract]

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