dbPTM

RIC1_SCHPO - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RIC1_SCHPO
UniProt AC	O42656
Protein Name	Guanine nucleotide exchange factor subunit ric1 {ECO:0000305}
Gene Name	ric1
Organism	Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast).
Sequence Length	1052
Subcellular Localization	Golgi apparatus membrane Single-pass membrane protein.
Protein Description	Probable component of a guanine nucleotide exchange factor (GEF) that may be required for efficient fusion of endosome-derived vesicles with the Golgi..
Protein Sequence	MYFLHGTPQRIQLSSRAIQICRIPKVSFFVVLTETEILIYQIRPLTLISKITKSQNLFERHGKNKKIAVNSEYGIIAVATEKNYVAVYHFTLNASKPVLTPSPYLTRYDDGPGEIFGPIKCEIQYKLAMRYGGGLKCLEIQRDSIVYAADSAPIIQVSTLETTDPNKLWKVSSKQYDLREVTWFLDHSSLISRLYFDVKIDTFFWMSTDGRVYANIGVSSNTNTKSLFGLCVHNPVDLNKSDNDKDINEDLESKLREKKATVLSTNARFSLLYVGTADGTVYAYEIRDFGRQYVQTHSFKYSASSGKVNHIATTGDGHQVMVGYDDGWATLSPYLNLCCASSETEYFNFGLSCGFWDRDSSSFYGLGSKNFSSTGEAEGTGLSTPIIAESLKENDEFFAMEKENVDIQYLSQNDNTNDVLYSITDSKQFISTIYILPFLKSTIVSSVQSTLQVCGAQTSDRLYISKSYEFCSSVKNNFGIDFWDQVEYPQPYVASEWPIRYVSIKDDGSLIAIAGLHGLAIYVCSKKTWFLYKDANMEQLISVTCPMIWCSQFLLAGVVCESNFELHLYKAKGPLDDRENLAKLSFTSTIVTMSVCDEYSLVVYTADNFLHHIRFDINELGRLELDYLTSVNFAPIFTTPSRVRSITLLLPKDLANIQPSDLLFYAVLLVLINGKLVLLSLKKQHSKELLYQCSMLAGDVEFYFINGSQEIPSLFHSIWIMTGKGLKLWLSFSEILSSVLINTKNLIDGLPKFLNTSKRVSLENFHRLSVEDLRSPSFVYKNGVDCNFDNTHLAKLIKNVNISEKFQKECIDLESQGCLLTVLSNYGLLLTAYTQGHKNLVNKMEYAHIQIGVYPFLPEIVRALLLLDKREQAIDLVKTYGHLHYINFVLEKLLSSSLLTYNSSQRDKLLYEVSLLFKDLQEFTTFKIVLGCLRKTEAEYWPMIFKYFGEPKDLMKKCLETEDVKSAAECLIIWQIHQGSASCASTFLSIYEMALKIKNWDVCTELSSYLVSLDPEKRLLKTALELLDEGPDSKDIRLYDQFNNLMKEVDKY

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
293	Phosphorylation	IRDFGRQYVQTHSFK ECCCCHHEEEEEEEE	7.99	28889911
761	Phosphorylation	LNTSKRVSLENFHRL CCCCCCCCHHHHHCC	33.72	25720772
769	Phosphorylation	LENFHRLSVEDLRSP HHHHHCCCHHHHCCC	24.34	21712547
775	Phosphorylation	LSVEDLRSPSFVYKN CCHHHHCCCCEEECC	31.99	21712547
777	Phosphorylation	VEDLRSPSFVYKNGV HHHHCCCCEEECCCC	28.70	21712547

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RIC1_SCHPO !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RIC1_SCHPO !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RIC1_SCHPO !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RYH1_SCHPO	ryh1	genetic	20623139
PPK19_SCHPO	ppk19	genetic	20623139
SAT1_SCHPO	sat1	physical	21035342
RYH1_SCHPO	ryh1	physical	21035342
RYH1_SCHPO	ryh1	genetic	21035342

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RIC1_SCHPO

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Phosphoproteome analysis of fission yeast."; Wilson-Grady J.T., Villen J., Gygi S.P.; J. Proteome Res. 7:1088-1097(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-293, AND MASSSPECTROMETRY.	18257517 [Abstract]