dbPTM

RHOV_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RHOV_HUMAN
UniProt AC	Q96L33
Protein Name	Rho-related GTP-binding protein RhoV
Gene Name	RHOV {ECO:0000312\|HGNC:HGNC:18313}
Organism	Homo sapiens (Human).
Sequence Length	236
Subcellular Localization	Cell membrane Lipid-anchor Cytoplasmic side . Endosome membrane Lipid-anchor Cytoplasmic side . Treatment with TNF activates endosomal but not plasma membrane RHOV.
Protein Description	Plays a role in the control of the actin cytoskeleton via activation of the JNK pathway..
Protein Sequence	MPPRELSEAEPPPLRAPTPPPRRRSAPPELGIKCVLVGDGAVGKSSLIVSYTCNGYPARYRPTALDTFSVQVLVDGAPVRIELWDTAGQEDFDRLRSLCYPDTDVFLACFSVVQPSSFQNITEKWLPEIRTHNPQAPVLLVGTQADLRDDVNVLIQLDQGGREGPVPQPQAQGLAEKIRACCYLECSALTQKNLKEVFDSAILSAIEHKARLEKKLNAKGVRTLSRCRWKKFFCFV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	PPPLRAPTPPPRRRS CCCCCCCCCCCCCCC	47.66	23186163
25	Phosphorylation	TPPPRRRSAPPELGI CCCCCCCCCCCCCCC	43.23	25159151
33	Ubiquitination	APPELGIKCVLVGDG CCCCCCCEEEEECCC	19.25	-
177	Ubiquitination	QAQGLAEKIRACCYL HHHHHHHHHHHHHHH	31.70	-
192	Ubiquitination	ECSALTQKNLKEVFD HCHHHCHHCHHHHHH	60.04	-
195	Ubiquitination	ALTQKNLKEVFDSAI HHCHHCHHHHHHHHH	62.31	-
209	Ubiquitination	ILSAIEHKARLEKKL HHHHHHHHHHHHHHH	23.55	-
234	S-palmitoylation	CRWKKFFCFV----- CCEEEEEEEC-----	3.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RHOV_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RHOV_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RHOV_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RHOV_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RHOV_HUMAN

Related Literatures of Post-Translational Modification