RHOB_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHOB_RAT
• UniProt AC: P62747
• Protein Name: Rho-related GTP-binding protein RhoB
• Gene Name: Rhob
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 196
• Subcellular Localization: Late endosome membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Nucleus. Cleavage furrow. Late endosomal membrane (geranylgeranylated form). Plasma membrane (farnesylated form). Also detected at the nuclear margin and in the nucleus. Translocates
• Protein Description: Mediates apoptosis in neoplastically transformed cells after DNA damage. Not essential for development but affects cell adhesion and growth factor signaling in transformed cells. Plays a negative role in tumorigenesis as deletion causes tumor formation. Involved in intracellular protein trafficking of a number of proteins. Targets PKN1 to endosomes and is involved in trafficking of the EGF receptor from late endosomes to lysosomes. Also required for stability and nuclear trafficking of AKT1/AKT which promotes endothelial cell survival during vascular development. Serves as a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Required for genotoxic stress-induced cell death in breast cancer cells (By similarity)..
• Protein Sequence: MAAIRKKLVVVGDGACGKTCLLIVFSKDEFPEVYVPTVFENYVADIEVDGKQVELALWDTAGQEDYDRLRPLSYPDTDVILMCFSVDSPDSLENIPEKWVPEVKHFCPNVPIILVANKKDLRSDEHVRTELARMKQEPVRTDDGRAMAVRIQAYDYLECSAKTKEGVREVFETATRAALQKRYGSQNGCINCCKVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
135	Ubiquitination	RTELARMKQEPVRTD HHHHHHHHCCCCCCC	46.05	-
154	Phosphorylation	MAVRIQAYDYLECSA EEEEEEEEEEECCCC	6.69	-
189	S-palmitoylation	RYGSQNGCINCCKVL HHCCCCCCCCCEEEC	2.37	-
192	S-palmitoylation	SQNGCINCCKVL--- CCCCCCCCEEEC---	0.90	-
193	Methylation	QNGCINCCKVL---- CCCCCCCEEEC----	2.71	-
193	Farnesylation	QNGCINCCKVL---- CCCCCCCEEEC----	2.71	-
193	Geranylgeranylation	QNGCINCCKVL---- CCCCCCCEEEC----	2.71	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHOB_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHOB_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHOB_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RHOB_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.