RHM3_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHM3_ARATH
• UniProt AC: Q9LH76
• Protein Name: Trifunctional UDP-glucose 4,6-dehydratase/UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase/UDP-4-keto-L-rhamnose-reductase RHM3 {ECO:0000305|PubMed:17190829}
• Gene Name: RHM3 {ECO:0000303|PubMed:15134748}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 664
• Protein Description: Trifunctional enzyme involved in UDP-beta-L-rhamnose biosynthesis, a precursor of the primary cell wall components rhamnogalacturonan I (RG-I) and rhamnogalacturonan II (RG-II). [PubMed: 17190829 Catalyzes the dehydration of UDP-glucose to form UDP-4-dehydro-6-deoxy-D-glucose followed by the epimerization of the C3' and C5' positions of UDP-4-dehydro-6-deoxy-D-glucose to form UDP-4-keto-beta-L-rhamnose and the reduction of UDP-4-keto-beta-L-rhamnose to yield UDP-beta-L-rhamnose (By similarity]
• Protein Sequence: MATYKPKNILITGAAGFIASHVANRLVRSYPDYKIVVLDKLDYCSNLKNLNPSKSSPNFKFVKGDIASADLVNYLLITEEIDTIMHFAAQTHVDNSFGNSFEFTKNNIYGTHVLLEACKVTGQIRRFIHVSTDEVYGETDEDASVGNHEASQLLPTNPYSATKAGAEMLVMAYGRSYGLPVITTRGNNVYGPNQFPEKLIPKFILLAMNGKPLPIHGDGSNVRSYLYCEDVAEAFEVVLHKGEVNHVYNIGTTRERRVIDVANDISKLFGIDPDSTIQYVENRPFNDQRYFLDDQKLKKLGWCERTNWEEGLRKTMEWYTENPEWWGDVSGALLPHPRMLMMPGDRHSDGSDEHKNADGNQTFTVVTPTKAGCSGDKRSLKFLIYGKTGWLGGLLGKLCEKQGIPYEYGKGRLEDRASLIADIRSIKPSHVFNAAGLTGRPNVDWCESHKTETIRVNVAGTLTLADVCRENDLLMMNFATGCIFEYDAAHPEGSGIGFKEEDKPNFTGSFYSKTKAMVEELLREFDNVCTLRVRMPISSDLNNPRNFITKISRYNKVVNIPNSMTILDELLPISIEMAKRNLRGIWNFTNPGVVSHNEILEMYKSYIEPDFKWSNFNLEEQAKVIVAPRSNNEMDGAKLSKEFPEMLSIKDSLIKYVFEPNKRT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
348	Phosphorylation	MMPGDRHSDGSDEHK ECCCCCCCCCCCCCC	44.56	23776212
351	Phosphorylation	GDRHSDGSDEHKNAD CCCCCCCCCCCCCCC	44.83	23776212
362	Phosphorylation	KNADGNQTFTVVTPT CCCCCCCEEEEECCC	25.85	23776212
364	Phosphorylation	ADGNQTFTVVTPTKA CCCCCEEEEECCCCC	19.90	23776212
367	Phosphorylation	NQTFTVVTPTKAGCS CCEEEEECCCCCCCC	22.39	23776212
369	Phosphorylation	TFTVVTPTKAGCSGD EEEEECCCCCCCCCC	24.94	23776212
406	Phosphorylation	CEKQGIPYEYGKGRL HHHCCCCCCCCCCCH	21.62	19880383
408	Phosphorylation	KQGIPYEYGKGRLED HCCCCCCCCCCCHHH	20.49	19880383

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHM3_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHM3_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHM3_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of RHM3_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.