RHG33_HUMAN - dbPTM
RHG33_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHG33_HUMAN
UniProt AC O14559
Protein Name Rho GTPase-activating protein 33
Gene Name ARHGAP33
Organism Homo sapiens (Human).
Sequence Length 1287
Subcellular Localization
Protein Description May be involved in several stages of intracellular trafficking. Could play an important role in the regulation of glucose transport by insulin. May act as a downstream effector of RHOQ/TC10 in the regulation of insulin-stimulated glucose transport (By similarity)..
Protein Sequence MVARSTDSLDGPGEGSVQPLPTAGGPSVKGKPGKRLSAPRGPFPRLADCAHFHYENVDFGHIQLLLSPDREGPSLSGENELVFGVQVTCQGRSWPVLRSYDDFRSLDAHLHRCIFDRRFSCLPELPPPPEGARAAQMLVPLLLQYLETLSGLVDSNLNCGPVLTWMELDNHGRRLLLSEEASLNIPAVAAAHVIKRYTAQAPDELSFEVGDIVSVIDMPPTEDRSWWRGKRGFQVGFFPSECVELFTERPGPGLKADADGPPCGIPAPQGISSLTSAVPRPRGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEAHGVVDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPLLTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMHARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLFSDTFTSAGLDPAGRCLLPRPKSLAGSCPSTRLLTLEEAQARTQGRLGTPTEPTTPKAPASPAERRKGERGEKQRKPGGSSWKTFFALGRGPSVPRKKPLPWLGGTRAPPQPSGSRPDTVTLRSAKSEESLSSQASGAGLQRLHRLRRPHSSSDAFPVGPAPAGSCESLSSSSSSESSSSESSSSSSESSAAGLGALSGSPSHRTSAWLDDGDELDFSPPRCLEGLRGLDFDPLTFRCSSPTPGDPAPPASPAPPAPASAFPPRVTPQAISPRGPTSPASPAALDISEPLAVSVPPAVLELLGAGGAPASATPTPALSPGRSLRPHLIPLLLRGAEAPLTDACQQEMCSKLRGAQGPLGPDMESPLPPPPLSLLRPGGAPPPPPKNPARLMALALAERAQQVAEQQSQQECGGTPPASQSPFHRSLSLEVGGEPLGTSGSGPPPNSLAHPGAWVPGPPPYLPRQQSDGSLLRSQRPMGTSRRGLRGPAQVSAQLRAGGGGRDAPEAAAQSPCSVPSQVPTPGFFSPAPRECLPPFLGVPKPGLYPLGPPSFQPSSPAPVWRSSLGPPAPLDRGENLYYEIGASEGSPYSGPTRSWSPFRSMPPDRLNASYGMLGQSPPLHRSPDFLLSYPPAPSCFPPDHLGYSAPQHPARRPTPPEPLYVNLALGPRGPSPASSSSSSPPAHPRSRSDPGPPVPRLPQKQRAPWGPRTPHRVPGPWGPPEPLLLYRAAPPAYGRGGELHRGSLYRNGGQRGEGAGPPPPYPTPSWSLHSEGQTRSYC
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
5 (in isoform 12)Phosphorylation-27.1628387310
8PhosphorylationMVARSTDSLDGPGEG
CCCCCCCCCCCCCCC		28.57-
37PhosphorylationGKPGKRLSAPRGPFP
CCCCCCCCCCCCCCC		40.0124719451
37 (in isoform 11)Phosphorylation-40.0124719451
67O-linked_GlycosylationGHIQLLLSPDREGPS
CEEEEEECCCCCCCC		25.4030379171
74O-linked_GlycosylationSPDREGPSLSGENEL
CCCCCCCCCCCCCEE		46.1330379171
178PhosphorylationHGRRLLLSEEASLNI
HHCEEEECCHHHCCH		33.1023403867
182PhosphorylationLLLSEEASLNIPAVA
EEECCHHHCCHHHHH		25.8123403867
197PhosphorylationAAHVIKRYTAQAPDE
HHHHHHHHCCCCCCC		11.0427251275
198PhosphorylationAHVIKRYTAQAPDEL
HHHHHHHCCCCCCCC		19.1427251275
206PhosphorylationAQAPDELSFEVGDIV
CCCCCCCEEECCCEE		19.8127251275
406PhosphorylationPLLTYQLYGKFSEAM
CEEEEEEECCHHHHH		11.6216777849
406 (in isoform 11)Phosphorylation-11.62-
410PhosphorylationYQLYGKFSEAMSVPG
EEEECCHHHHHCCCC		28.1228450419
414PhosphorylationGKFSEAMSVPGEEER
CCHHHHHCCCCCHHH		32.0128450419
434 (in isoform 10)Phosphorylation-36.5724719451
442PhosphorylationPHYRTLEYLLRHLAR
CCHHHHHHHHHHHHH		17.7222817900
458PhosphorylationARHSANTSMHARNLA
HHHHHCCHHHHHHHH		14.3724114839
497 (in isoform 10)Phosphorylation-2.9027251275
500 (in isoform 10)Phosphorylation-20.9724719451
532PhosphorylationCLLPRPKSLAGSCPS
CCCCCCHHHCCCCCC		26.5722210691
532 (in isoform 11)Phosphorylation-26.5727251275
539PhosphorylationSLAGSCPSTRLLTLE
HHCCCCCCCCEEEHH		30.4122210691
544PhosphorylationCPSTRLLTLEEAQAR
CCCCCEEEHHHHHHH		36.3922210691
552 (in isoform 11)Phosphorylation-38.09-
552PhosphorylationLEEAQARTQGRLGTP
HHHHHHHHCCCCCCC		38.0918077418
558PhosphorylationRTQGRLGTPTEPTTP
HHCCCCCCCCCCCCC		31.4622817900
558 (in isoform 11)Phosphorylation-31.46-
560 (in isoform 11)Phosphorylation-55.20-
560PhosphorylationQGRLGTPTEPTTPKA
CCCCCCCCCCCCCCC		55.2018077418
563PhosphorylationLGTPTEPTTPKAPAS
CCCCCCCCCCCCCCC		49.8822210691
564PhosphorylationGTPTEPTTPKAPASP
CCCCCCCCCCCCCCH		33.2423403867
570PhosphorylationTTPKAPASPAERRKG
CCCCCCCCHHHHHCC		24.4724719451
593O-linked_GlycosylationPGGSSWKTFFALGRG
CCCCCHHHHHCCCCC		20.0930379171
624PhosphorylationAPPQPSGSRPDTVTL
CCCCCCCCCCCCEEE		45.00-
628PhosphorylationPSGSRPDTVTLRSAK
CCCCCCCCEEEECCC		20.34-
630PhosphorylationGSRPDTVTLRSAKSE
CCCCCCEEEECCCCH		20.67-
633PhosphorylationPDTVTLRSAKSEESL
CCCEEEECCCCHHHH		43.0627732954
636PhosphorylationVTLRSAKSEESLSSQ
EEEECCCCHHHHHHH		46.4425849741
639PhosphorylationRSAKSEESLSSQASG
ECCCCHHHHHHHCCC		29.5121406692
641PhosphorylationAKSEESLSSQASGAG
CCCHHHHHHHCCCHH		29.6821406692
642PhosphorylationKSEESLSSQASGAGL
CCHHHHHHHCCCHHH		34.7523312004
644 (in isoform 10)Phosphorylation-16.3324719451
677PhosphorylationAPAGSCESLSSSSSS
CCCCCCCCCCCCCCC		37.5730576142
682PhosphorylationCESLSSSSSSESSSS
CCCCCCCCCCCCCCC		39.5730576142
683PhosphorylationESLSSSSSSESSSSE
CCCCCCCCCCCCCCC		39.8230576142
727PhosphorylationDGDELDFSPPRCLEG
CCCCCCCCCCHHHHC		33.3927732954
780PhosphorylationRVTPQAISPRGPTSP
CCCCCCCCCCCCCCC		16.1524719451
827PhosphorylationATPTPALSPGRSLRP
CCCCCCCCCCCCCCH		27.6724719451
934PhosphorylationSQSPFHRSLSLEVGG
HHCCCCCCEEEEECC		17.4628348404
936PhosphorylationSPFHRSLSLEVGGEP
CCCCCCEEEEECCEE		24.5928348404
955O-linked_GlycosylationGSGPPPNSLAHPGAW
CCCCCCCCCCCCCCC		32.4830379171
964 (in isoform 11)Phosphorylation-38.5827251275
975PhosphorylationPYLPRQQSDGSLLRS
CCCCCCCCCCCCCCC		35.2821406692
978PhosphorylationPRQQSDGSLLRSQRP
CCCCCCCCCCCCCCC		29.2621406692
978O-linked_GlycosylationPRQQSDGSLLRSQRP
CCCCCCCCCCCCCCC		29.2630379171
982PhosphorylationSDGSLLRSQRPMGTS
CCCCCCCCCCCCCCC		30.4321406692
1103PhosphorylationPYSGPTRSWSPFRSM
CCCCCCCCCCCHHCC		34.0924732914
1105PhosphorylationSGPTRSWSPFRSMPP
CCCCCCCCCHHCCCH		18.5324732914
1125PhosphorylationSYGMLGQSPPLHRSP
CCCCCCCCCCCCCCC		27.0423312004
1163PhosphorylationQHPARRPTPPEPLYV
CCCCCCCCCCCCEEE		50.0628152594
1169PhosphorylationPTPPEPLYVNLALGP
CCCCCCEEEEEEECC		9.6728152594
1194MethylationSSPPAHPRSRSDPGP
CCCCCCCCCCCCCCC		34.5324395419
1244MethylationAAPPAYGRGGELHRG
CCCCCCCCCCCCCCC		36.9558859673
1252PhosphorylationGGELHRGSLYRNGGQ
CCCCCCCCCCCCCCC		23.3725072903
1254PhosphorylationELHRGSLYRNGGQRG
CCCCCCCCCCCCCCC		12.0625072903
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
406YPhosphorylationKinaseFYNP06241
PSP
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHG33_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHG33_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RHG33_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHG33_HUMAN

loading...

Related Literatures of Post-Translational Modification

TOP
© 2024 Institute of Bioinformatics and Systems Biology, NYCU | Designed by : BiOmics Laboratory