RHG22_MOUSE - dbPTM
RHG22_MOUSE - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHG22_MOUSE
UniProt AC Q8BL80
Protein Name Rho GTPase-activating protein 22
Gene Name Arhgap22
Organism Mus musculus (Mouse).
Sequence Length 702
Subcellular Localization Cytoplasm . Nucleus . Mainly cytoplasmic. Some fraction is nuclear.
Protein Description Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. Acts as a GTPase activator for the RAC1 by converting it to an inactive GDP-bound state. Inhibits RAC1-dependent lamellipodia formation. May also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter..
Protein Sequence MLPTASSKRRTFAARYFTRSKSLVMGEQSRSPGRPLVPHKLGPVLKAGWLRKQRSIMKNWQQRWFVLRGDQLFYYKDKDESKPQGFISLQGTQVTELLPDPEDPGKHLFEITPGGATEREKVPANPEALLLMASSQRDMEDWVQAIRRVIWAPLGRGIFGQRLEDTVHHERKFGPRLAPLLVEQCVDFIRERGLSEEGLFRMPGQANLVRDLQDSFDCGEKPLFDSTTDVHTVASLLKLYLRELPEPVIPFARYEDFLSCAQLLTKDEGEGTVELAKQVSNLPQANYNLLRYICKFLDEVQAHSDVNKMSVQNLATVFGPNILRPQIEDPVTIMEGTSLVQHLMTVLIRKHGQLFAATSLEEPASPHGTVEWGSEEVTRDHRGEPGSPGLPTHRTSSLDGPAAAVLSRTSPPRLGSQTGPAATSPGKKMHTLPVWKSSFRQQGSRSESPKGVNSSLEVPIISSGGNWLINGLSSLRSHRRASSGDRLKDTGSAQRLSTYDNVPPSSQFSSTASVASTSWSVASSSREASVSSCTACRASNSSACSSLHTEWALEPSPLPSSSEGHQSPDLGHSLDEPCVGSGSSEPNDPGSPTQAHVRRCRALQGQVAELRAELCQQRTEYKRSLKSIEEGSADLRKQMSRLEEELDQERKKYAMLEIKLRNSERAREDAERRNQLLQREMEEFFSTLGSLTTGTKGSRAPE
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
4Phosphorylation----MLPTASSKRRT
----CCCCCCHHHHH		34.9023737553
6Phosphorylation--MLPTASSKRRTFA
--CCCCCCHHHHHHH		38.5823737553
7Phosphorylation-MLPTASSKRRTFAA
-CCCCCCHHHHHHHH		27.9323737553
20PhosphorylationAARYFTRSKSLVMGE
HHHHHHCCCHHHCCC		24.4425777480
22PhosphorylationRYFTRSKSLVMGEQS
HHHHCCCHHHCCCCC		27.6930635358
29PhosphorylationSLVMGEQSRSPGRPL
HHHCCCCCCCCCCCC		30.3525777480
31PhosphorylationVMGEQSRSPGRPLVP
HCCCCCCCCCCCCCC		36.6328066266
215PhosphorylationLVRDLQDSFDCGEKP
HHHHHHHHCCCCCCC		15.2624719451
365PhosphorylationTSLEEPASPHGTVEW
ECCCCCCCCCCCEEC		28.3030387612
369PhosphorylationEPASPHGTVEWGSEE
CCCCCCCCEECCCCC		16.5321659605
387PhosphorylationDHRGEPGSPGLPTHR
CCCCCCCCCCCCCCC		26.8927087446
392PhosphorylationPGSPGLPTHRTSSLD
CCCCCCCCCCCCCCC		29.0925619855
395PhosphorylationPGLPTHRTSSLDGPA
CCCCCCCCCCCCCCH		18.3126239621
396PhosphorylationGLPTHRTSSLDGPAA
CCCCCCCCCCCCCHH		28.9426239621
397PhosphorylationLPTHRTSSLDGPAAA
CCCCCCCCCCCCHHH		29.8426824392
409PhosphorylationAAAVLSRTSPPRLGS
HHHHHHCCCCCCCCC		42.0627087446
410PhosphorylationAAVLSRTSPPRLGSQ
HHHHHCCCCCCCCCC		31.6227087446
416PhosphorylationTSPPRLGSQTGPAAT
CCCCCCCCCCCCCCC		29.2130387612
418PhosphorylationPPRLGSQTGPAATSP
CCCCCCCCCCCCCCC		46.9925159016
423PhosphorylationSQTGPAATSPGKKMH
CCCCCCCCCCCCEEE		37.2425159016
424PhosphorylationQTGPAATSPGKKMHT
CCCCCCCCCCCEEEC		27.2526824392
431PhosphorylationSPGKKMHTLPVWKSS
CCCCEEECCCCCHHH		29.2922942356
437PhosphorylationHTLPVWKSSFRQQGS
ECCCCCHHHHHCCCC		20.9924719451
438PhosphorylationTLPVWKSSFRQQGSR
CCCCCHHHHHCCCCC		22.2629514104
444PhosphorylationSSFRQQGSRSESPKG
HHHHCCCCCCCCCCC		28.4424719451
473PhosphorylationNWLINGLSSLRSHRR
CEEECCHHHHHHCCC		28.8225159016
474PhosphorylationWLINGLSSLRSHRRA
EEECCHHHHHHCCCC		32.6124719451
482PhosphorylationLRSHRRASSGDRLKD
HHHCCCCCCCCCCCC		32.8024899341
483PhosphorylationRSHRRASSGDRLKDT
HHCCCCCCCCCCCCC		43.6724899341
499PhosphorylationSAQRLSTYDNVPPSS
CCCCCCCCCCCCCHH		11.3521183079
511PhosphorylationPSSQFSSTASVASTS
CHHHCCCCCCHHCCC		23.0421183079
591PhosphorylationSEPNDPGSPTQAHVR
CCCCCCCCCCHHHHH		30.1125338131
593PhosphorylationPNDPGSPTQAHVRRC
CCCCCCCCHHHHHHH		39.8320531401
627PhosphorylationEYKRSLKSIEEGSAD
HHHHHHHHHHHCCHH		40.2930387612
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHG22_MOUSE !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHG22_MOUSE !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHG22_MOUSE !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
RAC1_MOUSERac1physical
14966113
Drug and Disease Associations
Kegg Drug
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHG22_MOUSE

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Related Literatures of Post-Translational Modification

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