RHG20_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHG20_HUMAN
• UniProt AC: Q9P2F6
• Protein Name: Rho GTPase-activating protein 20
• Gene Name: ARHGAP20
• Organism: Homo sapiens (Human).
• Sequence Length: 1191
• Protein Description: GTPase activator for the Rho-type GTPases by converting them to an inactive GDP-bound state..
• Protein Sequence: MEAMSPQQETLGGQPGRSSSLTGVSRLAGGSCTKKKMKTLAERRRSAPSLILDKALQKRPTTRDSPSASVDTCTFLSSLVCSNRTLLIDGRAELKRGLQRQERHLFLFNDLFVVAKIKYNNNFKIKNKIKLTDMWTASCVDEVGEGNTNAMKSFVLGWPTVNFVATFSSPEQKDKWLSLLQRYINLEKEKDYPKSIPLKIFAKDIGNCAYSKTITVMNSDTANEVINMSLPMLGITGSERDYQLWVNSGKEEAPYPLIGHEYPYGIKMSHLRDSALLTPGSKDSTTPFNLQEPFLMEQLPREMQCQFILKPSRLAAAQQLSDSGHKTFKRRRSIINWAFWRGSSTHLDNLPSSPTSPMPGQLFGISLPNICENDNLPKPVLDMLFFLNQKGPLTKGIFRQSANVKSCRELKEKLNSGVEVHLDCESIFVIASVLKDFLRNIPGSIFSSDLYDHWVSVMDQGNDEEKINTVQRLLDQLPRANVVLLRYLFGVLHNIEQHSSSNQMTAFNLAVCVAPSILWPPASSSPELENEFTKKVSLLIQFLIENCLRIFGEEITSLFREVSVRCDTRENASDISCFQLNDSSYDSLENELNEDVDAPCSDLVKKLGQGSRSMDSVLTLSDYDLDQPEVEGLLTLSDFDLAHSKDEDVQMKRPLESKPVNILVYTKIPLRDHARAPSAMCTPSYLSTAAANAAKSLRRHRRCSEPSIDYLDSKLSYLREFYQKKLRKSSCDAILSQKDEDYLKQNQPLQEEGKTCFKQSLVTGTDVSKKNATTQNTKKKSLSGSEGNHVKLFPKSKPVAISVASYSPMSSQDHSKNQPFDVNTSGYSPPHTADALKGPRTHRRCSEPNIEDQNRKLTYLRGIYSKKQHKTSCEAGLLHGEEDYLKRHKSLQMEGQKLINQSLVMGIEVGKSSATNQNTEKVLPPRLNLCPRTSYSSLSSPGTSPSGSSVSSQDSAFSQISEHSVFTPTETSSPIDCTFQAQRKREDLSPDFSNASHVSGMPGPSSGQACSRPAYTKKDTMEWHSQMHSVTLHPSTWLRNGVASLKNWSLKKKAKAARPEEEKIASPKGPLEPPPHASGVPEANSLQEEQKDLPLRAAEGLSPVQSAQRCSSSPFQDSERHCSSPFSLVESRLKLCMKSHEEIEPGSQSSSGSLPWERASASSWTLEDATSPDSGPTVVCDIEDRYLTKDI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	LGGQPGRSSSLTGVS CCCCCCCCHHCCCCH	30.14	-
20	Phosphorylation	GQPGRSSSLTGVSRL CCCCCCHHCCCCHHH	31.06	-
22	Phosphorylation	PGRSSSLTGVSRLAG CCCCHHCCCCHHHCC	37.17	-
46	Phosphorylation	TLAERRRSAPSLILD HHHHHHHCCCHHHHH	42.60	29978859
61	Phosphorylation	KALQKRPTTRDSPSA HHHHHCCCCCCCCCC	38.20	25022875
62	Phosphorylation	ALQKRPTTRDSPSAS HHHHCCCCCCCCCCC	34.85	25022875
65	Phosphorylation	KRPTTRDSPSASVDT HCCCCCCCCCCCCCH	19.91	25022875
67	Phosphorylation	PTTRDSPSASVDTCT CCCCCCCCCCCCHHH	36.81	25022875
69	Phosphorylation	TRDSPSASVDTCTFL CCCCCCCCCCHHHHH	25.51	25022875
72	Phosphorylation	SPSASVDTCTFLSSL CCCCCCCHHHHHHHH	15.99	25022875
74	Phosphorylation	SASVDTCTFLSSLVC CCCCCHHHHHHHHHH	29.69	25022875
77	Phosphorylation	VDTCTFLSSLVCSNR CCHHHHHHHHHHCCC	19.89	25022875
78	Phosphorylation	DTCTFLSSLVCSNRT CHHHHHHHHHHCCCE	27.28	25022875
82	Phosphorylation	FLSSLVCSNRTLLID HHHHHHHCCCEEEEC	23.13	25022875
195	Phosphorylation	KEKDYPKSIPLKIFA HCCCCCCCCCCEEEE	25.57	22210691
242	Phosphorylation	ITGSERDYQLWVNSG CCCCCCCEEEEECCC	16.24	-
248	Phosphorylation	DYQLWVNSGKEEAPY CEEEEECCCCCCCCC	41.44	-
278	Phosphorylation	LRDSALLTPGSKDST CCCCEECCCCCCCCC	26.84	27251275
312	Phosphorylation	CQFILKPSRLAAAQQ CCEEECHHHHHHHHH	38.04	27251275
321	Phosphorylation	LAAAQQLSDSGHKTF HHHHHHHCHHCCHHH	25.95	28348404
323	Phosphorylation	AAQQLSDSGHKTFKR HHHHHCHHCCHHHHH	39.15	28348404
327	Phosphorylation	LSDSGHKTFKRRRSI HCHHCCHHHHHHHHH	28.81	28348404
333	Phosphorylation	KTFKRRRSIINWAFW HHHHHHHHHHHHHHH	26.47	22617229
394	Phosphorylation	LNQKGPLTKGIFRQS HCCCCCCCHHHHHCC	30.29	20860994
557	Phosphorylation	IFGEEITSLFREVSV HHHHHHHHHHHHHHC	31.04	24719451
657	Phosphorylation	QMKRPLESKPVNILV CCCCCCCCCCEEEEE	50.36	-
704	Phosphorylation	LRRHRRCSEPSIDYL HHHHHCCCCCCHHHH	51.21	26657352
729	Phosphorylation	YQKKLRKSSCDAILS HHHHHHHHCHHHHHC	29.75	26657352
730	Phosphorylation	QKKLRKSSCDAILSQ HHHHHHHCHHHHHCC	21.03	22617229
760	Phosphorylation	GKTCFKQSLVTGTDV CCCHHHHHHCCCCCH	25.95	29449344
763	Phosphorylation	CFKQSLVTGTDVSKK HHHHHHCCCCCHHHC	39.39	27135362
765	Phosphorylation	KQSLVTGTDVSKKNA HHHHCCCCCHHHCCC	24.70	27135362
768	Phosphorylation	LVTGTDVSKKNATTQ HCCCCCHHHCCCCCC	40.50	27135362
824	Phosphorylation	NQPFDVNTSGYSPPH CCCCCCCCCCCCCCC	24.31	28348404
825	Phosphorylation	QPFDVNTSGYSPPHT CCCCCCCCCCCCCCH	30.45	28348404
828	Phosphorylation	DVNTSGYSPPHTADA CCCCCCCCCCCHHHH	35.17	22617229
846	Phosphorylation	PRTHRRCSEPNIEDQ CCCCCCCCCCCHHHH	55.03	24245541
871	Phosphorylation	YSKKQHKTSCEAGLL CCCCCCCCCCHHHCC	36.16	22210691
902	Phosphorylation	GQKLINQSLVMGIEV HHHHHHHHHHHEEEE	20.60	29449344
989	Phosphorylation	QRKREDLSPDFSNAS HHHCHHCCCCCCCCC	34.44	-
1102	Phosphorylation	LRAAEGLSPVQSAQR CHHHCCCCHHHHHHH	33.60	27499020

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHG20_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHG20_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHG20_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of RHG20_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.