RHF2A_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RHF2A_ARATH
• UniProt AC: Q9ZT42
• Protein Name: E3 ubiquitin-protein ligase RHF2A {ECO:0000305}
• Gene Name: RHF2A {ECO:0000303|PubMed:9781696}
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 375
• Protein Description: E3 ubiquitin-protein ligase involved in the positive regulation of the gametogenesis progression. Required for the degradation of KRP6, a cyclin-dependent kinase inhibitor which accumulates during meiosis and blocks the progression of subsequent mitoses during gametophytes development. Functions in association with RHF1A..
• Protein Sequence: MEGAGETTTSEGHLTSAAAFVEGGIQDACDDACSICLESFCESDPSTLTSCKHEYHLQCILEWCQRSSQCPMCWQSISLKDPTSQELLEAVEQERNFRFNPTRNATIFRHPTLGDFELQHLPVGVDNAEIEERIIQHLAAAAAMGRARHGVRREGHRSRSSSQGHQQFMVFSSQPNASSPPPHPPMPSSPSQRDESDTVSNLPHNALGEGSHQSNTQPPTSSHPRQVSPSASDSNSRPLNQSSPSEQDRAGPSELQSFSESLKSRLNAVSTRYKESISKNTRNWKDRLFSRNTSMADLGSEVKREVSAGIATVSRMMERLETRENSRPSTASVSDVSENHTPETNNEHNRAAAGDEHSVNERGVKETCATGSGSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
162	Phosphorylation	GHRSRSSSQGHQQFM CCCCCCCCCCCCEEE	41.23	29654922
189	Phosphorylation	PHPPMPSSPSQRDES CCCCCCCCHHHCCCC	23.77	29654922
228	Phosphorylation	SSHPRQVSPSASDSN CCCCCCCCCCCCCCC	12.56	27545962
230	Phosphorylation	HPRQVSPSASDSNSR CCCCCCCCCCCCCCC	32.66	30407730
232	Phosphorylation	RQVSPSASDSNSRPL CCCCCCCCCCCCCCC	46.00	30407730
234	Phosphorylation	VSPSASDSNSRPLNQ CCCCCCCCCCCCCCC	33.92	30407730
236	Phosphorylation	PSASDSNSRPLNQSS CCCCCCCCCCCCCCC	38.95	30407730
242	Phosphorylation	NSRPLNQSSPSEQDR CCCCCCCCCCCHHCC	43.04	19880383
243	Phosphorylation	SRPLNQSSPSEQDRA CCCCCCCCCCHHCCC	23.76	30407730
245	Phosphorylation	PLNQSSPSEQDRAGP CCCCCCCCHHCCCCH	50.25	30407730
293	Phosphorylation	DRLFSRNTSMADLGS HHHHHCCCCHHHHCH	20.83	25561503
294	Phosphorylation	RLFSRNTSMADLGSE HHHHCCCCHHHHCHH	18.60	23111157

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RHF2A_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RHF2A_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RHF2A_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of RHF2A_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.