RHDF1_HUMAN - dbPTM
RHDF1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RHDF1_HUMAN
UniProt AC Q96CC6
Protein Name Inactive rhomboid protein 1
Gene Name RHBDF1
Organism Homo sapiens (Human).
Sequence Length 855
Subcellular Localization Endoplasmic reticulum membrane
Multi-pass membrane protein . Golgi apparatus membrane
Multi-pass membrane protein . Predominantly localized in the endoplasmic reticulum membrane (PubMed:15965977).
Protein Description Rhomboid protease-like protein which has no protease activity but regulates the secretion of several ligands of the epidermal growth factor receptor. Indirectly activates the epidermal growth factor receptor signaling pathway and may thereby regulate sleep, cell survival, proliferation and migration..
Protein Sequence MSEARRDSTSSLQRKKPPWLKLDIPSAVPLTAEEPSFLQPLRRQAFLRSVSMPAETAHISSPHHELRRPVLQRQTSITQTIRRGTADWFGVSKDSDSTQKWQRKSIRHCSQRYGKLKPQVLRELDLPSQDNVSLTSTETPPPLYVGPCQLGMQKIIDPLARGRAFRVADDTAEGLSAPHTPVTPGAASLCSFSSSRSGFHRLPRRRKRESVAKMSFRAAAALMKGRSVRDGTFRRAQRRSFTPASFLEEDTTDFPDELDTSFFAREGILHEELSTYPDEVFESPSEAALKDWEKAPEQADLTGGALDRSELERSHLMLPLERGWRKQKEGAAAPQPKVRLRQEVVSTAGPRRGQRIAVPVRKLFAREKRPYGLGMVGRLTNRTYRKRIDSFVKRQIEDMDDHRPFFTYWLTFVHSLVTILAVCIYGIAPVGFSQHETVDSVLRNRGVYENVKYVQQENFWIGPSSEALIHLGAKFSPCMRQDPQVHSFIRSAREREKHSACCVRNDRSGCVQTSEEECSSTLAVWVKWPIHPSAPELAGHKRQFGSVCHQDPRVCDEPSSEDPHEWPEDITKWPICTKNSAGNHTNHPHMDCVITGRPCCIGTKGRCEITSREYCDFMRGYFHEEATLCSQVHCMDDVCGLLPFLNPEVPDQFYRLWLSLFLHAGILHCLVSICFQMTVLRDLEKLAGWHRIAIIYLLSGVTGNLASAIFLPYRAEVGPAGSQFGILACLFVELFQSWQILARPWRAFFKLLAVVLFLFTFGLLPWIDNFAHISGFISGLFLSFAFLPYISFGKFDLYRKRCQIIIFQVVFLGLLAGLVVLFYVYPVRCEWCEFLTCIPFTDKFCEKYELDAQLH
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMSEARRDSTSSLQRK
CCHHHHCCCHHHHHC		28.5133259812
9PhosphorylationSEARRDSTSSLQRKK
CHHHHCCCHHHHHCC		26.9925850435
10PhosphorylationEARRDSTSSLQRKKP
HHHHCCCHHHHHCCC		32.7629255136
11PhosphorylationARRDSTSSLQRKKPP
HHHCCCHHHHHCCCC		28.7229255136
49PhosphorylationRRQAFLRSVSMPAET
HHHHHHHHCCCCCHH		22.2323403867
51PhosphorylationQAFLRSVSMPAETAH
HHHHHHCCCCCHHCC		21.9427696853
56PhosphorylationSVSMPAETAHISSPH
HCCCCCHHCCCCCCC		26.1629978859
60PhosphorylationPAETAHISSPHHELR
CCHHCCCCCCCHHHH		28.1329255136
61PhosphorylationAETAHISSPHHELRR
CHHCCCCCCCHHHHH		27.8729255136
75PhosphorylationRPVLQRQTSITQTIR
HHHHHHHHCCHHHHH		25.0430266825
76PhosphorylationPVLQRQTSITQTIRR
HHHHHHHCCHHHHHH		18.4629255136
78PhosphorylationLQRQTSITQTIRRGT
HHHHHCCHHHHHHCC		21.3030266825
80PhosphorylationRQTSITQTIRRGTAD
HHHCCHHHHHHCCCC		14.0623403867
85PhosphorylationTQTIRRGTADWFGVS
HHHHHHCCCCHHCCC		21.4523403867
92PhosphorylationTADWFGVSKDSDSTQ
CCCHHCCCCCCCCCH		30.9922617229
95PhosphorylationWFGVSKDSDSTQKWQ
HHCCCCCCCCCHHHH		36.8828857561
97PhosphorylationGVSKDSDSTQKWQRK
CCCCCCCCCHHHHHH		36.3725002506
98PhosphorylationVSKDSDSTQKWQRKS
CCCCCCCCHHHHHHH		38.8825002506
128PhosphorylationLRELDLPSQDNVSLT
HHHCCCCCCCCCCCC		58.4224719451
133PhosphorylationLPSQDNVSLTSTETP
CCCCCCCCCCCCCCC		31.9828348404
135PhosphorylationSQDNVSLTSTETPPP
CCCCCCCCCCCCCCC		26.5426657352
136PhosphorylationQDNVSLTSTETPPPL
CCCCCCCCCCCCCCE		29.5524719451
137PhosphorylationDNVSLTSTETPPPLY
CCCCCCCCCCCCCEE		38.3528348404
139PhosphorylationVSLTSTETPPPLYVG
CCCCCCCCCCCEEEC		40.9828348404
171PhosphorylationAFRVADDTAEGLSAP
CEEECCCCCCCCCCC		27.4422199227
176PhosphorylationDDTAEGLSAPHTPVT
CCCCCCCCCCCCCCC		51.0822199227
180PhosphorylationEGLSAPHTPVTPGAA
CCCCCCCCCCCCCHH		20.5629507054
183PhosphorylationSAPHTPVTPGAASLC
CCCCCCCCCCHHHHC		19.7425850435
188PhosphorylationPVTPGAASLCSFSSS
CCCCCHHHHCCCCCC		29.4025850435
191PhosphorylationPGAASLCSFSSSRSG
CCHHHHCCCCCCCCC		33.1922199227
193PhosphorylationAASLCSFSSSRSGFH
HHHHCCCCCCCCCCC		15.8825850435
194PhosphorylationASLCSFSSSRSGFHR
HHHCCCCCCCCCCCC		27.9722199227
195PhosphorylationSLCSFSSSRSGFHRL
HHCCCCCCCCCCCCC		29.3022199227
197PhosphorylationCSFSSSRSGFHRLPR
CCCCCCCCCCCCCCC		48.0027251275
215PhosphorylationRESVAKMSFRAAAAL
HHHHHHHHHHHHHHH		15.7524719451
240PhosphorylationFRRAQRRSFTPASFL
CHHHHHHCCCCHHHC		35.3427251275
242PhosphorylationRAQRRSFTPASFLEE
HHHHHCCCCHHHCCC		21.1329507054
245PhosphorylationRRSFTPASFLEEDTT
HHCCCCHHHCCCCCC		31.4128348404
251PhosphorylationASFLEEDTTDFPDEL
HHHCCCCCCCCCHHH		31.3828348404
252PhosphorylationSFLEEDTTDFPDELD
HHCCCCCCCCCHHHC		48.2228348404
260PhosphorylationDFPDELDTSFFAREG
CCCHHHCHHHHHCCC		39.8124719451
261PhosphorylationFPDELDTSFFAREGI
CCHHHCHHHHHCCCC		20.3128348404
274PhosphorylationGILHEELSTYPDEVF
CCCHHHHCCCCHHHC		29.2224972180
275PhosphorylationILHEELSTYPDEVFE
CCHHHHCCCCHHHCC		52.2623403867
276PhosphorylationLHEELSTYPDEVFES
CHHHHCCCCHHHCCC		12.8128348404
283PhosphorylationYPDEVFESPSEAALK
CCHHHCCCCCHHHHH		23.4325849741
285PhosphorylationDEVFESPSEAALKDW
HHHCCCCCHHHHHCH		49.5022199227
290UbiquitinationSPSEAALKDWEKAPE
CCCHHHHHCHHHCHH		56.9522817900
294UbiquitinationAALKDWEKAPEQADL
HHHHCHHHCHHHCCC		66.0622817900
302PhosphorylationAPEQADLTGGALDRS
CHHHCCCCCCCCCHH		33.8329255136
309PhosphorylationTGGALDRSELERSHL
CCCCCCHHHHHHHHC		46.3225849741
313UbiquitinationLDRSELERSHLMLPL
CCHHHHHHHHCCEEH		41.8422817900
317UbiquitinationELERSHLMLPLERGW
HHHHHHCCEEHHHCH		2.7922817900
346PhosphorylationRLRQEVVSTAGPRRG
CHHHHHHHCCCCCCC		20.0929255136
347PhosphorylationLRQEVVSTAGPRRGQ
HHHHHHHCCCCCCCC		24.8329255136
380PhosphorylationLGMVGRLTNRTYRKR
CCHHHHHCCCHHHHH		22.69-
383PhosphorylationVGRLTNRTYRKRIDS
HHHHCCCHHHHHHHH		29.73-
390PhosphorylationTYRKRIDSFVKRQIE
HHHHHHHHHHHHHHH		29.5730266825
487PhosphorylationRQDPQVHSFIRSARE
CCCHHHHHHHHHHHH		24.4224719451
583N-linked_GlycosylationCTKNSAGNHTNHPHM
CCCCCCCCCCCCCCC		38.2315965977
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RHDF1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RHDF1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RHDF1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RHDF1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RHDF1_HUMAN

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Related Literatures of Post-Translational Modification
N-linked Glycosylation
ReferencePubMed
"Characterization of a human rhomboid homolog, p100hRho/RHBDF1, whichinteracts with TGF-alpha family ligands.";
Nakagawa T., Guichard A., Castro C.P., Xiao Y., Rizen M., Zhang H.-Z.,Hu D., Bang A., Helms J., Bier E., Derynck R.;
Dev. Dyn. 233:1315-1331(2005).
Cited for: FUNCTION, SUBCELLULAR LOCATION, SUBUNIT, INTERACTION WITH TGFA ANDHBEGF, GLYCOSYLATION AT ASN-583, MUTAGENESIS OF ASN-131; ASN-381 ANDASN-583, AND TISSUE SPECIFICITY.

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