| UniProt ID | RHBL2_HUMAN | |
|---|---|---|
| UniProt AC | Q9NX52 | |
| Protein Name | Rhomboid-related protein 2 | |
| Gene Name | RHBDL2 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 303 | |
| Subcellular Localization |
Rhomboid-related protein 2, C-terminal fragment: Cell membrane Multi-pass membrane protein . |
|
| Protein Description | Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.. | |
| Protein Sequence | MAAVHDLEMESMNLNMGREMKEELEEEEKMREDGGGKDRAKSKKVHRIVSKWMLPEKSRGTYLERANCFPPPVFIISISLAELAVFIYYAVWKPQKQWITLDTGILESPFIYSPEKREEAWRFISYMLVHAGVQHILGNLCMQLVLGIPLEMVHKGLRVGLVYLAGVIAGSLASSIFDPLRYLVGASGGVYALMGGYFMNVLVNFQEMIPAFGIFRLLIIILIIVLDMGFALYRRFFVPEDGSPVSFAAHIAGGFAGMSIGYTVFSCFDKALLKDPRFWIAIAAYLACVLFAVFFNIFLSPAN | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 11 | Phosphorylation | VHDLEMESMNLNMGR CHHHHHHHHCCHHHH | 16.20 | 28348404 | |
| 21 | Ubiquitination | LNMGREMKEELEEEE CHHHHHHHHHHHHHH | 43.19 | - | |
| 29 | Acetylation | EELEEEEKMREDGGG HHHHHHHHHHHCCCC | 46.68 | 7380183 | |
| 50 | Phosphorylation | KKVHRIVSKWMLPEK HHHHHHHHHHCCCCC | 20.44 | - | |
| 96 | Acetylation | YAVWKPQKQWITLDT HHHHCCHHHEEEECC | 57.01 | 11790101 | |
| 116 | Acetylation | PFIYSPEKREEAWRF CCCCCHHHHHHHHHH | 69.37 | 11790111 | |
| 163 | Phosphorylation | GLRVGLVYLAGVIAG CHHHHHHHHHHHHHH | 8.90 | - | |
| 171 | Phosphorylation | LAGVIAGSLASSIFD HHHHHHHHHHHHCHH | 16.25 | - | |
| 174 | Phosphorylation | VIAGSLASSIFDPLR HHHHHHHHHCHHHHH | 29.29 | - | |
| 175 | Phosphorylation | IAGSLASSIFDPLRY HHHHHHHHCHHHHHH | 22.97 | - | |
| 243 | Phosphorylation | FFVPEDGSPVSFAAH HCCCCCCCCCCHHHH | 34.16 | 22210691 | |
| 246 | Phosphorylation | PEDGSPVSFAAHIAG CCCCCCCCHHHHHHC | 16.74 | 22210691 | |
| 266 | Phosphorylation | SIGYTVFSCFDKALL CCCHHHHHHHHHHHH | 14.99 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RHBL2_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RHBL2_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RHBL2_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| EFNB3_HUMAN | EFNB3 | physical | 15047175 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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