RH42_ARATH - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RH42_ARATH
• UniProt AC: Q8H0U8
• Protein Name: DEAD-box ATP-dependent RNA helicase 42
• Gene Name: RH42
• Organism: Arabidopsis thaliana (Mouse-ear cress).
• Sequence Length: 1166
• Subcellular Localization: Nucleus .
• Protein Description: Helicase required for pre-mRNA splicing, cold-responsive gene regulation and cold tolerance..
• Protein Sequence: MEVEKSKYRSEDLDVVEEEADLKKSRRDRDRSNERKKDKGSEKRREKDRRKKRVKSSDSEDDYDRDDDEEREKRKEKERERRRRDKDRVKRRSERRKSSDSEDDVEEEDERDKRRVNEKERGHREHERDRGKDRKRDREREERKDKEREREKDRERREREREEREKERVKERERREREDGERDRREREKERGSRRNRERERSREVGNEESDDDVKRDLKRRRKEGGERKEKEREKSVGRSSRHEDSPKRKSVEDNGEKKEKKTREEELEDEQKKLDEEVEKRRRRVQEWQELKRKKEEAESESKGDADGNEPKAGKAWTLEGESDDEEGHPEEKSETEMDVDEETKPENDGDAKMVDLENETAATVSESGGDGAVDEEEIDPLDAFMNTMVLPEVEKFCNGAPPPAVNDGTLDSKMNGKESGDRPKKGFNKALGRIIQGEDSDSDYSEPKNDDDPSLDEDDEEFMKRVKKTKAEKLSLVDHSKIEYEPFRKNFYIEVKDISRMTQEEVNTYRKELELKVHGKDVPRPIKFWHQTGLTSKILDTMKKLNYEKPMPIQTQALPIIMSGRDCIGVAKTGSGKTLGFVLPMLRHIKDQPPVEAGDGPIGLVMAPTRELVQQIHSDIRKFSKPLGIRCVPVYGGSGVAQQISELKRGTEIVVCTPGRMIDILCTSSGKITNLRRVTFLVMDEADRMFDMGFEPQITRIIQNIRPERQTVLFSATFPRQVETLARKVLNKPVEIQVGGRSVVNKDITQLVEVRPESDRFLRLLELLGEWSEKGKILVFVQSQEKCDALYRDMIKSSYPCLSLHGGKDQTDRESTISDFKNDVCNLLIATSVAARGLDVKELELVVNFDAPNHYEDYVHRVGRTGRAGRKGCAVTFISEDDAKYAPDLVKALELSEQPVPDDLKALADGFMVKVKQGIEQAHGTGYGGSGFKFNEEEEEVRKAAKKAQAKEYGFEEDKSDSEDENDVVRKAGGGEISQQQATFAQIAAIAAAAKAAAAAPVSAPVTANQLLANGGGLAAMPGVLPVTVPTLPSEGAGRAAAMVAAMNLQHNLAKIQADAMPEHYEAELEINDFPQNARWKVTHKETLGPISEWTGAAITTRGQFYPTGRIPGPGERKLYLFIEGPSEKSVKHAKAELKRVLEDITNQAMSSLPGGASGRYSVL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
56	Phosphorylation	RRKKRVKSSDSEDDY HHHHHCCCCCCCCCC	36.20	25561503
57	Phosphorylation	RKKRVKSSDSEDDYD HHHHCCCCCCCCCCC	39.16	25561503
59	Phosphorylation	KRVKSSDSEDDYDRD HHCCCCCCCCCCCCC	44.89	29654922
98	Phosphorylation	RRSERRKSSDSEDDV HHHHHHCCCCCCCCC	37.25	23111157
99	Phosphorylation	RSERRKSSDSEDDVE HHHHHCCCCCCCCCC	48.46	30407730
101	Phosphorylation	ERRKSSDSEDDVEEE HHHCCCCCCCCCCHH	44.89	23111157
202	Phosphorylation	RNRERERSREVGNEE HHHHHHHHHHCCCCC	28.21	23776212
210	Phosphorylation	REVGNEESDDDVKRD HHCCCCCCCHHHHHH	39.91	23776212
251	Phosphorylation	EDSPKRKSVEDNGEK CCCCCCCCCCCCCHH	34.47	25561503
319	Phosphorylation	PKAGKAWTLEGESDD CCCCCCEEECCCCCC	21.57	23776212
324	Phosphorylation	AWTLEGESDDEEGHP CEEECCCCCCCCCCC	62.31	30291188
335	Phosphorylation	EGHPEEKSETEMDVD CCCCCCCCCCCCCCC	53.70	23776212
337	Phosphorylation	HPEEKSETEMDVDEE CCCCCCCCCCCCCCC	43.64	23776212
345	Phosphorylation	EMDVDEETKPENDGD CCCCCCCCCCCCCCC	50.26	23776212
442	Phosphorylation	RIIQGEDSDSDYSEP HHHCCCCCCCCCCCC	34.41	23776212
444	Phosphorylation	IQGEDSDSDYSEPKN HCCCCCCCCCCCCCC	42.26	23776212
446	Phosphorylation	GEDSDSDYSEPKNDD CCCCCCCCCCCCCCC	20.91	23776212
447	Phosphorylation	EDSDSDYSEPKNDDD CCCCCCCCCCCCCCC	53.03	23776212
456	Phosphorylation	PKNDDDPSLDEDDEE CCCCCCCCCCCCHHH	56.28	23776212
659	Phosphorylation	GTEIVVCTPGRMIDI CCEEEEECCCCEEEE	19.71	19880383
669	Phosphorylation	RMIDILCTSSGKITN CEEEEEECCCCCCCC	23.60	19880383
670	Phosphorylation	MIDILCTSSGKITNL EEEEEECCCCCCCCC	35.78	19880383
671	Phosphorylation	IDILCTSSGKITNLR EEEEECCCCCCCCCC	26.42	19880383
955	Phosphorylation	KKAQAKEYGFEEDKS HHHHHHHHCCCCCCC	26.80	23776212
962	Phosphorylation	YGFEEDKSDSEDEND HCCCCCCCCCCCCCH	59.70	30291188
964	Phosphorylation	FEEDKSDSEDENDVV CCCCCCCCCCCCHHH	54.78	23776212

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RH42_ARATH !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RH42_ARATH !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RH42_ARATH !!

Protein-Protein Interaction

Oops, there are no PPI records of RH42_ARATH !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale Arabidopsis phosphoproteome profiling reveals novelchloroplast kinase substrates and phosphorylation networks.";
Reiland S., Messerli G., Baerenfaller K., Gerrits B., Endler A.,Grossmann J., Gruissem W., Baginsky S.;
Plant Physiol. 150:889-903(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-210 AND SER-324, ANDMASS SPECTROMETRY.
PubMed: 19376835