| UniProt ID | RGS7_RAT | |
|---|---|---|
| UniProt AC | P49803 | |
| Protein Name | Regulator of G-protein signaling 7 | |
| Gene Name | Rgs7 | |
| Organism | Rattus norvegicus (Rat). | |
| Sequence Length | 477 | |
| Subcellular Localization |
Cytoplasm, cytosol . Cytoplasm . Cell membrane . Membrane Peripheral membrane protein Cytoplasmic side . Interaction with PKD1 promotes location at the cell membrane. Interaction with RGS7BP promotes location at the cell membrane. |
|
| Protein Description | Regulates G protein-coupled receptor signaling cascades. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form. The RGS7/GNB5 dimer enhances GNAO1 GTPase activity. May play a role in synaptic vesicle exocytosis. Modulates the activity of potassium channels that are activated by GNAO1 in response to muscarinic acetylcholine receptor M2/CHRM2 signaling. [PubMed: 10092682] | |
| Protein Sequence | MAQGNNYGQTSNGVAEESPNMLVYRKMEDVIARMQDEKNGIPIRTVKSFLSKIPSVFSGSDIVQWLIKNLTIEDPVEALHLGTLMAAHGYFFPISDHVLTLKDDGTFYRFQTPYFWPSNCWEPENTDYAVYLCKRTMQNKARLELADYEAESLARLQRAFARKWEFIFMQAEAQAKVDKKRDKIERKILDSQERAFWDVHRPVPGCVNTTEVDIKKSSRMRNPHKTRKSVYGLQNDIRSHSPTHTPTPETKPPTEDELHRQIKYWQIQLDRHRLKMSKVADSLLSYTEQYVEYDPFLVPPDPSNPWLSDDTTFWELEASKEPSQQRVKRWGFGMDEALKDPVGREQFLKFLESEFSSENLRFWLAVEDLKKRPIREVPSRVQEIWQEFLAPGAPSAINLDSKSYDKTTQNVKEPGRYTFEDAQEHIYKLMKSDSYPRFIRSSAYQELLQAKRKGRNIPIFPCHKNCTPTLRASTNLL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 38 | Acetylation | IARMQDEKNGIPIRT HHHHHHHCCCCCHHH | 69.62 | 22902405 | |
| 225 | Ubiquitination | SRMRNPHKTRKSVYG HCCCCCCCCCHHHHH | 51.81 | - | |
| 229 | Phosphorylation | NPHKTRKSVYGLQND CCCCCCHHHHHCHHC | 19.79 | 27097102 | |
| 231 | Phosphorylation | HKTRKSVYGLQNDIR CCCCHHHHHCHHCHH | 21.14 | - | |
| 239 | Phosphorylation | GLQNDIRSHSPTHTP HCHHCHHHCCCCCCC | 28.75 | 27097102 | |
| 241 | Phosphorylation | QNDIRSHSPTHTPTP HHCHHHCCCCCCCCC | 32.51 | 30411139 | |
| 243 | Phosphorylation | DIRSHSPTHTPTPET CHHHCCCCCCCCCCC | 41.20 | 28432305 | |
| 245 | Phosphorylation | RSHSPTHTPTPETKP HHCCCCCCCCCCCCC | 31.19 | 27097102 | |
| 247 | Phosphorylation | HSPTHTPTPETKPPT CCCCCCCCCCCCCCC | 34.61 | 27097102 | |
| 250 | Phosphorylation | THTPTPETKPPTEDE CCCCCCCCCCCCHHH | 50.48 | 27097102 | |
| 349 | Ubiquitination | VGREQFLKFLESEFS CCHHHHHHHHHHHCC | 49.55 | - | |
| 407 | Phosphorylation | DSKSYDKTTQNVKEP CCCCCCCCCCCCCCC | 30.62 | 16641100 | |
| 408 | Phosphorylation | SKSYDKTTQNVKEPG CCCCCCCCCCCCCCC | 24.72 | 16641100 | |
| 428 | Acetylation | DAQEHIYKLMKSDSY HHHHHHHHHHCCCCC | 41.31 | 22902405 | |
| 434 | Phosphorylation | YKLMKSDSYPRFIRS HHHHCCCCCCHHHCC | 44.09 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of RGS7_RAT !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of RGS7_RAT !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of RGS7_RAT !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
Oops, there are no PPI records of RGS7_RAT !! | ||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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