RGS3_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RGS3_RAT
• UniProt AC: P49797
• Protein Name: Regulator of G-protein signaling 3
• Gene Name: Rgs3
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 967
• Subcellular Localization: Cytoplasm . Membrane ; Peripheral membrane protein . Nucleus . Long isoforms are cytoplasmic and associated with the plasma membrane. Short isoforms are nuclear.
• Protein Description: Down-regulates signaling from heterotrimeric G-proteins by increasing the GTPase activity of the alpha subunits, thereby driving them into their inactive GDP-bound form. Down-regulates G-protein-mediated release of inositol phosphates and activation of MAP kinases..
• Protein Sequence: MNRFNGLCKVCSERRYRQITIRRGKDGFGFTICCDSPVRVQAVDSGGPAERAGLQQLDTVLQLNERPVEHWKCVELAHEIRSCPSEIILLVWRVVPQIKPGPDGGVLRRASCKSTHDLLSPPNKREKNCTHGAPTRPEQRHSCHLVCDSSDGLLLGGWERYTEVGKRSGQHTLPALSRATTPTDPNYIILAPLNPGSQLLRPVYQEDAIPEEPGTTTKGKSYTGLGKKSRLMKTVQTMKGHSNYQDCSALRPHIPHSSYGTYVTLAPKVLVFPVFVQPLDLCNPARTLLLSEELLLYEGRNKTSQVTLFAYSDLLLFTKEEEPGRCDVLRNPLYLQSVKLQEGSSEDLKFCVLYLAEKAECLFTLEAHSQEQKKRVCWCLSENIAKQQQLAATPTERKMFETEADEKEMPLVEGKGPGAEERTPSKDPSPSQELPPGQELPPSKDPSPSQELPPGQELPPSKDPSPSQELPPGQELPSSKNPSPSQELPAGQDLPPRKESFSGQEAAPGPESPSSEDIATCQNPPQSPETSTSKDSPPGQGSSPTTEVPSCQGLPAGQESTSQDPLLSQEPPAIPESSASDQNVLPSQESPPSQGSLSEKALAEQTISPGELPAATAGEPSASRPNFVIPEVRLDSAYSQQDGAHGGSSGEDEDAEEGEEGEEGEEDEEDDTNDDNYGDRNEAKRSSLIETGQGAEGGLSLRVQNSLRRRTHSEGSLLQEARGPCFASDTTLHCSDGEGTTSTWAIPSPRTLKKELGRNGGSMHHLSLFFTGHRKMSGTDLADDVEASRKRKSKNIAKDMKNKLAIFRRRNESPGAQPAGKADKTTKSFKPTSEEALKWSESLEKLLLHKYGLEVFQAFLRTEFSEENLEFWLACEDFKKVKSQSKMAAKAKKIFAEFIAIQACKEVNLDSYTREHTKENLQSITRGCFDLAQKRIFGLMEKDSYPRFLRSDLYLDLINQKKMSPPL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
142	Phosphorylation	TRPEQRHSCHLVCDS CCHHHCCCCEEEEEC	12.86	25575281
167	Methylation	RYTEVGKRSGQHTLP ECCCHHHHCCCCCCC	39.84	-
483	Phosphorylation	LPSSKNPSPSQELPA CCCCCCCCCCCCCCC	46.72	27097102
485	Phosphorylation	SSKNPSPSQELPAGQ CCCCCCCCCCCCCCC	40.39	27097102
500	Phosphorylation	DLPPRKESFSGQEAA CCCCCCCCCCCCCCC	27.96	27097102
502	Phosphorylation	PPRKESFSGQEAAPG CCCCCCCCCCCCCCC	49.17	27097102
512	Phosphorylation	EAAPGPESPSSEDIA CCCCCCCCCCHHHHC	32.96	27097102
514	Phosphorylation	APGPESPSSEDIATC CCCCCCCCHHHHCCC	56.49	27097102
515	Phosphorylation	PGPESPSSEDIATCQ CCCCCCCHHHHCCCC	42.55	27097102
520	Phosphorylation	PSSEDIATCQNPPQS CCHHHHCCCCCCCCC	18.24	27097102
527	Phosphorylation	TCQNPPQSPETSTSK CCCCCCCCCCCCCCC	30.40	27097102
530	Phosphorylation	NPPQSPETSTSKDSP CCCCCCCCCCCCCCC	40.46	27097102
531	Phosphorylation	PPQSPETSTSKDSPP CCCCCCCCCCCCCCC	29.08	27097102
532	Phosphorylation	PQSPETSTSKDSPPG CCCCCCCCCCCCCCC	47.41	27097102
533	Phosphorylation	QSPETSTSKDSPPGQ CCCCCCCCCCCCCCC	33.94	27097102
606	Phosphorylation	EKALAEQTISPGELP HHHHHHCCCCCCCCC	18.22	27097102
608	Phosphorylation	ALAEQTISPGELPAA HHHHCCCCCCCCCCC	30.18	27097102
616	Phosphorylation	PGELPAATAGEPSAS CCCCCCCCCCCCCCC	36.98	27097102
686	Phosphorylation	DRNEAKRSSLIETGQ CCCHHHHHHHHHCCC	28.87	27097102
687	Phosphorylation	RNEAKRSSLIETGQG CCHHHHHHHHHCCCC	37.08	27097102
691	Phosphorylation	KRSSLIETGQGAEGG HHHHHHHCCCCCCCC	28.01	27097102
700	Phosphorylation	QGAEGGLSLRVQNSL CCCCCCEEHHHHCHH	19.87	28432305
711	Phosphorylation	QNSLRRRTHSEGSLL HCHHHHCCCCCCCHH	28.13	27097102
713	Phosphorylation	SLRRRTHSEGSLLQE HHHHCCCCCCCHHHH	42.94	27097102
716	Phosphorylation	RRTHSEGSLLQEARG HCCCCCCCHHHHHCC	23.12	27097102
728	Phosphorylation	ARGPCFASDTTLHCS HCCCCEECCCEEEEC	18.42	27097102
730	Phosphorylation	GPCFASDTTLHCSDG CCCEECCCEEEECCC	28.85	27097102
731	Phosphorylation	PCFASDTTLHCSDGE CCEECCCEEEECCCC	21.35	27097102
735	Phosphorylation	SDTTLHCSDGEGTTS CCCEEEECCCCCCCC	37.59	27097102
740	Phosphorylation	HCSDGEGTTSTWAIP EECCCCCCCCCCCCC	17.17	27097102
741	Phosphorylation	CSDGEGTTSTWAIPS ECCCCCCCCCCCCCC	34.71	27097102
742	Phosphorylation	SDGEGTTSTWAIPSP CCCCCCCCCCCCCCC	23.07	27097102
743	Phosphorylation	DGEGTTSTWAIPSPR CCCCCCCCCCCCCCC	19.47	27097102
748	Phosphorylation	TSTWAIPSPRTLKKE CCCCCCCCCCHHHHH	22.39	27097102
777	Phosphorylation	FTGHRKMSGTDLADD ECCCCCCCCCCHHHH	41.39	27097102
779	Phosphorylation	GHRKMSGTDLADDVE CCCCCCCCCHHHHHH	22.12	27097102
828	Phosphorylation	KADKTTKSFKPTSEE CCCCCCCCCCCCHHH	36.09	25575281
832	Phosphorylation	TTKSFKPTSEEALKW CCCCCCCCHHHHHHH	49.73	25575281
964	Phosphorylation	LINQKKMSPPL---- HHHHCCCCCCC----	32.04	22673903

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RGS3_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RGS3_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RGS3_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RGS3_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.