RFX2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFX2_MOUSE
• UniProt AC: P48379
• Protein Name: DNA-binding protein RFX2
• Gene Name: Rfx2
• Organism: Mus musculus (Mouse).
• Sequence Length: 717
• Subcellular Localization: Nucleus . Cytoplasm . Mainly expressed in the nucleus and at lower level in cytoplasm.
• Protein Description: Transcription factor that acts as a key regulator of spermatogenesis. [PubMed: 26248850]
• Protein Sequence: MQNSEGGADSPASVALRPAAQPMPASPQRVLVQAAGSTPKGTPMQTLTLPRVQPVPPQVQHVYPAQVQYVEGGDAVYANGAIRAAYAYNPDPQLYAPSSAASYFETPGGTQVTVAASSPPAVPSHGMVGITMDVSGTPIVSGAGAYLIHGGMDGTRHSLAHTARSSPATLEMAIETLQKSEGLAPHKGGLLNSHLQWLLDNYETAEGVSLPRSSLYNHYLRHCQEHKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGIRLKPDSPLNRLQEDTQYMAMRQQPTHQKPRYRPAQKSDSLGDGSAHSNMHGMPDQAMATQGQHHQQYIDVSHVFPEFPAPDLGSTLLQESVTLHDVKALQLVYRRHCEATLDVVMNLQFQYIEKLWLSFWNCKATSSDSCASLPASDEDPEVTLLPKEKLISLCKCEPILQWMRSCDHILYQTLVETLIPDVLRPVPSSLTQAIRNFAKSLEGWLINAMSGFPQQVIQTKVGVVSAFAQTLRRYTSLNHLAQAARAVLQNTSQINQMLSDLNRVDFANVQEQASWVCQCEESLVQRLEHDFKVTLQQQSSLDQWASWLDNVVTQVLKQHSGSPSFPKAARQFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMFYLVEHRVAQATGETPIAVMGEFNDLASLSLTLLDKEDIGDGHSSEADVDGRSLGEPLVKRERSDPSHPLQGI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MQNSEGGADSP ----CCCCCCCCCCC	22.26	25293948
10	Phosphorylation	NSEGGADSPASVALR CCCCCCCCCHHCCCC	23.10	25293948
13	Phosphorylation	GGADSPASVALRPAA CCCCCCHHCCCCCCC	16.00	25293948
26	Phosphorylation	AAQPMPASPQRVLVQ CCCCCCCCCCEEEEE	18.72	26643407
38	Phosphorylation	LVQAAGSTPKGTPMQ EEEECCCCCCCCCCC	28.27	27841257
165	Phosphorylation	SLAHTARSSPATLEM CHHHHHCCCHHHHHH	37.90	19060867
166	Phosphorylation	LAHTARSSPATLEMA HHHHHCCCHHHHHHH	17.01	25293948
169	Phosphorylation	TARSSPATLEMAIET HHCCCHHHHHHHHHH	27.00	25293948
235	Phosphorylation	LEPVNAASFGKLIRS CCCCCHHHHHHHHHH	31.92	21454597
242	Phosphorylation	SFGKLIRSVFMGLRT HHHHHHHHHHHHHCC	16.83	23737553
249	Phosphorylation	SVFMGLRTRRLGTRG HHHHHHCCEECCCCC	25.78	-
271	Phosphorylation	GIRLKPDSPLNRLQE EEEECCCCCCHHHHH	39.55	21082442
411	Phosphorylation	SCASLPASDEDPEVT CCCCCCCCCCCCCCE	39.32	25293948
418	Phosphorylation	SDEDPEVTLLPKEKL CCCCCCCEECCHHHH	22.40	25293948
554	S-palmitoylation	QASWVCQCEESLVQR HHHHHHHCHHHHHHH	5.46	28680068
689	Phosphorylation	DIGDGHSSEADVDGR HCCCCCCCCCCCCCC	31.00	28973931

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFX2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFX2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFX2_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
MYNN_MOUSE	Mynn	physical	20211142

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.