RFX1_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RFX1_MOUSE
• UniProt AC: P48377
• Protein Name: MHC class II regulatory factor RFX1
• Gene Name: Rfx1
• Organism: Mus musculus (Mouse).
• Sequence Length: 963
• Subcellular Localization: Nucleus .
• Protein Description: Regulatory factor essential for MHC class II genes expression. Binds to the X boxes of MHC class II genes (By similarity)..
• Protein Sequence: MATQSYVTELQAAPQASQPPQAPPQALPQPPPPAAPQPPAAATPQPQYVTELQSPQPQTQPPGSQKQYVAELPAAPAPSQPATPAPSPVAQQYIVVTVSEGAMRASETVSEASPSSTASQTGVPTQVVQQVQGTQQRLLVQASVQAKPGHVSPLQLTNIQVPQQAIPTQHLVVQSPAPGTKSGQVSLTVHSAQQVHSAPERSPVQANNSTSKTAGTPAATVQQLQVHSVQQSVPVTQERSVVQATPQTKAGPVQQLTVQGLQPVHVAQEVQQLPQVPVPHVYSSQVQYVEGGDASYTASAIRSSTYQYPETPIYTQTAGTSYYEASGTAAQVSTPATSQTVASSGSVPMYVSGSPIVASSSSSEAGASNSSVGAGGNGGGGSSGGGSGGSSGSGAGTYVIQGGYMLGNASQSYSHTTRASPATVQWLLDNYETAEGVSLPRSTLYCHYLLHCQEQKLEPVNAASFGKLIRSVFMGLRTRRLGTRGNSKYHYYGLRIKASSPLLRLMEDQQHMAMRGQPFSQKQRLKPIQKMEGVANGVAVGQQSTGLSDISAQVQQYQQFLDASRSLPDFAELDLQGKVLPEGVGPGDIKAFQVLYREHCEAIVDVMVNLQFTLVETLWKTFWRYNLSQPSEAPPLAVHDEAEKRLPRASLVLLSKFQPVLQWTKHCDNVLYQGLVEILIPDVLRPIPSALTQAIRNFAKSLESWLTHAMVNIPEEMLRVKVAAAGAFAQTLRRYTSLNHLAQAARAVLQNTAQINQMLSDLNRVDFANVQEQASWVCRCEDRVVQRLEQDFKVTLQQQNSLEQWAAWLDGVVSQVLKPYQGSSGFPKAAKLFLLKWSFYSSMVIRDLTLRSAASFGSFHLIRLLYDEYMYYLIEHRVAQAKGETPIAVMGEFANLATSLNPLDPDKDEEEEEEEESEDELPQDISLAAGSESPALGPEALEPPAKLARTDTRGLFVQALPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
54	Phosphorylation	QYVTELQSPQPQTQP CEEEECCCCCCCCCC	37.82	-
106	Phosphorylation	SEGAMRASETVSEAS CCCCHHCCCCCHHCC	24.36	26160508
108	Phosphorylation	GAMRASETVSEASPS CCHHCCCCCHHCCCC	27.17	26160508
110	Phosphorylation	MRASETVSEASPSST HHCCCCCHHCCCCCC	34.56	27087446
113	Phosphorylation	SETVSEASPSSTASQ CCCCHHCCCCCCHHC	22.66	27087446
115	Phosphorylation	TVSEASPSSTASQTG CCHHCCCCCCHHCCC	37.51	26160508
116	Phosphorylation	VSEASPSSTASQTGV CHHCCCCCCHHCCCC	31.23	26160508
117	Phosphorylation	SEASPSSTASQTGVP HHCCCCCCHHCCCCC	34.37	26160508
119	Phosphorylation	ASPSSTASQTGVPTQ CCCCCCHHCCCCCHH	28.50	26160508
121	Phosphorylation	PSSTASQTGVPTQVV CCCCHHCCCCCHHHH	37.34	26160508
125	Phosphorylation	ASQTGVPTQVVQQVQ HHCCCCCHHHHHHCC	31.43	26160508
134	Phosphorylation	VVQQVQGTQQRLLVQ HHHHCCCCCEEEEEE	12.39	25777480
152	Phosphorylation	QAKPGHVSPLQLTNI ECCCCCCCCCCCCCC	17.76	25266776
157	Phosphorylation	HVSPLQLTNIQVPQQ CCCCCCCCCCCCCCC	19.81	25266776
168	Phosphorylation	VPQQAIPTQHLVVQS CCCCCCCCCEEEEEC	23.62	26824392
175	Phosphorylation	TQHLVVQSPAPGTKS CCEEEEECCCCCCCC	16.06	25266776
180	Phosphorylation	VQSPAPGTKSGQVSL EECCCCCCCCCEEEE	22.45	18846507
197	Phosphorylation	HSAQQVHSAPERSPV ECCCCCCCCCCCCCC	46.81	27681418
202	Phosphorylation	VHSAPERSPVQANNS CCCCCCCCCCCCCCC	27.97	26643407
209	Phosphorylation	SPVQANNSTSKTAGT CCCCCCCCCCCCCCC	33.59	27681418
210	Phosphorylation	PVQANNSTSKTAGTP CCCCCCCCCCCCCCC	36.04	27681418
216	Phosphorylation	STSKTAGTPAATVQQ CCCCCCCCCCCEEEE	13.80	25338131
370	Phosphorylation	SEAGASNSSVGAGGN CCCCCCCCCCCCCCC	24.73	-
371	Phosphorylation	EAGASNSSVGAGGNG CCCCCCCCCCCCCCC	28.90	-
397	Phosphorylation	SSGSGAGTYVIQGGY CCCCCCCEEEEECCE	17.68	-
398	Phosphorylation	SGSGAGTYVIQGGYM CCCCCCEEEEECCEE	8.47	-
464	Phosphorylation	LEPVNAASFGKLIRS CCCCCHHHHHHHHHH	31.92	21454597
471	Phosphorylation	SFGKLIRSVFMGLRT HHHHHHHHHHHHHCC	16.83	23737553
478	Phosphorylation	SVFMGLRTRRLGTRG HHHHHHCCEECCCCC	25.78	-
499	Phosphorylation	YGLRIKASSPLLRLM EEEEEECCCHHHHHH	27.73	23737553
500	Phosphorylation	GLRIKASSPLLRLME EEEEECCCHHHHHHH	25.15	23737553
778	S-palmitoylation	QEQASWVCRCEDRVV HHHHHHEEECHHHHH	3.15	28680068
885	Phosphorylation	VAQAKGETPIAVMGE HHHCCCCCCEEEEHH	28.76	23649490
931	Phosphorylation	DISLAAGSESPALGP CCHHHCCCCCCCCCH	30.12	23649490
933	Phosphorylation	SLAAGSESPALGPEA HHHCCCCCCCCCHHH	19.71	23649490
952	Phosphorylation	AKLARTDTRGLFVQA HHHCCCCCCCCCEEE	26.48	22942356
962	Phosphorylation	LFVQALPSS------ CCEEECCCC------	49.91	28833060
963	Phosphorylation	FVQALPSS------- CEEECCCC-------	42.15	28833060

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RFX1_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RFX1_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RFX1_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of RFX1_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.