dbPTM

RF12A_XENLA - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RF12A_XENLA
UniProt AC	Q641J8
Protein Name	E3 ubiquitin-protein ligase RNF12-A
Gene Name	rnf12-a
Organism	Xenopus laevis (African clawed frog).
Sequence Length	622
Subcellular Localization	Nucleus.
Protein Description	Acts as an E3 ubiquitin-protein ligase specific for ldb1, mediating ubiquitination and proteasome-dependent degradation of excess ldb1 in a RING-dependent manner. Does not degrade ldb1 bound to lhx1/lim1, nor lim1 itself and thus contributes to the establishment of proper ldb1-lhx1/lim1 stoichiometry and the formation of a ldb1-lhx1/lim1 complex. Interferes with Spemann organizer function and suppresses secondary axis formation induced by ldb1 and lhx1/lim1..
Protein Sequence	MESADSTGKGSIEQSESQRQSQMDRLDREEAFYQFVNNLNEDDYRLMRDNNLLGTPGEITKEELLRRLQQIKEGPPQPSTEETRGDSVSTGGDPAEDSSNGDSIIDWLNSVRQTGNTTRSGQRGNQSWRAVSRTNPNSGDFRFSLEINVNRTSGNPSMPSLDQSAEMPGAEDMEVSSQGEAENEPEPIPIATRSAPAEVTVEEAPIQRGQRRARSRSPDQRRTRARTDRSRSPLHHAVDPPIRRAPHSSSQTVDTSNTEEAEGSSRTRHHVSSQVQNSSSSNETEGSSRTRQHIPARQQVLGTEGQSQSTVHLSNPETRSSSQTPQTDSSTNAETTGTGQRPPTIVLDLQVRRVRPGDYRQRDSIANRTRSRSQTPNNTVTYESERGGFRRTFSRSERAGVRTYVSTIRIPIRRILNTGLSETTSVAIQTMLRQIMTGFGELSYFMYNDNDTDPNNPTAVSPTAAVPGEAQNNANAEVRAPSAEPTEPVAPVETDEGSNVSTTATRREGRNSRGAVTFEESGSLPFLSLAQFFLLNEDDDDQPRGLTKEQIDNLSTRNFGENDALKTCSVCITEYTEGNKLRKLPCSHEYHIHCIDRWLSENSTCPICRRAVLVASNRESIV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of RF12A_XENLA !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RF12A_XENLA !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RF12A_XENLA !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RF12A_XENLA !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RF12A_XENLA !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RF12A_XENLA

Related Literatures of Post-Translational Modification