RENT1_DROME - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RENT1_DROME
• UniProt AC: Q9VYS3
• Protein Name: Regulator of nonsense transcripts 1 homolog
• Gene Name: Upf1
• Organism: Drosophila melanogaster (Fruit fly).
• Sequence Length: 1180
• Subcellular Localization: Cytoplasm.
• Protein Description: RNA-dependent helicase and ATPase required for nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. Is recruited to mRNAs upon translation termination and undergoes a cycle of phosphorylation and dephosphorylation; its phosphorylation appears to be a key step in NMD. The formation of an Upf1-Upf2-Upf3 surveillance complex is believed to activate NMD (By similarity)..
• Protein Sequence: MSVDTYAPSSALSFLDMDDNELLPGADTQPTQYDYRDFTMPSTSQSQTQNDQLEIAQRCSAGDSHPRLASITNDLADLQFEEEDDEPGSSYVKELPPHACKYCGIHDPATVVMCNNCRKWFCNGRGSTSGSHIINHLVRAKHREVTLHGEGPLGETILECYSCGVRNVFVLGFIPAKADSVVVLLCRQPCAAQNSLKDMNWDQEQWKPLIADRCFLAWLVKQPSEQGQLRARQISAAQINKLEELWKENIEATFQDLEKPGIDSEPAHVLLRYEDGYQYEKTFGPLVRLEAEYDQKLKESATQENIEVRWDVGLNKKTIAYFTLAKTDSDMKLMHGDELRLHYVGELYNPWSEIGHVIKVPDNFGDDVGLELKSSTNAPVKCTSNFTVDFIWKCTSFDRMTRALCKFAIDRNSVSNFIYSRLLGHGRADSNDEVLFRGPQPKLFSAPHLPDLNRSQVYAVKHALQRPLSLIQGPPGTGKTVTSATIVYQLVKLHGGTVLVCAPSNTAVDQLTEKIHRTNLKVVRVCAKSREAIDSPVSFLALHNQIRNMETNSELKKLQQLKDETGELSSADEKRYRNLKRAAENQLLEAADVICCTCVGAGDGRLSRVKFTSILIDESMQSTEPECMVPVVLGAKQLILVGDHCQLGPVVMCKKAARAGLSQSLFERLVVLGIRPFRLEVQYRMHPELSQFPSNFFYEGSLQNGVCAEDRRLKLDFPWPQPERPMFFLVTQGQEEIAGSGTSFLNRTEAANVEKITTRFLKAGIKPEQIGIITPYEGQRAYLVQYMQYQGSLHSRLYQEIEIASVDAFQGREKDIIIMSCVRSNERQGIGFLNDPRRLNVALTRAKFGIIIVGNPKVLAKQQLWNHLLNFYKDRKVLVEGSLNNLKESLIHFQKPKKLVNSMNIGAHFMSTIIADAKEVMVPGSIYDRSGGYGQGRQMVGQSMNGGQYGGSGGGPYGNSPLGYGTPSSNSMVGFGLGNGGNGAAGGNNNFGGAGPSWAAAHLHHDSIGYISNEHGAAALGNMPVPVGMFMNMSNIPPRFYNQHQQAIMAVKQNRAIQQQTGNFSPGNSGPGVTGVGVGRSATPGGNKKTNKLGKSRVTGGGTGGAPLTQGSSVCNAAPYSQHPMPLSLQMTQPSGFALSQQPELSQDFGQISQMDGLLSQDVAFNASGERSLNQFSQPY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
42	Phosphorylation	YRDFTMPSTSQSQTQ CCCCCCCCCCCCCCC	29.84	29892262
43	Phosphorylation	RDFTMPSTSQSQTQN CCCCCCCCCCCCCCC	25.55	19429919
44	Phosphorylation	DFTMPSTSQSQTQND CCCCCCCCCCCCCCH	31.97	19429919
46	Phosphorylation	TMPSTSQSQTQNDQL CCCCCCCCCCCCHHH	34.66	19429919
48	Phosphorylation	PSTSQSQTQNDQLEI CCCCCCCCCCHHHHH	34.29	19429919
60	Phosphorylation	LEIAQRCSAGDSHPR HHHHHHHCCCCCCHH	37.16	19429919
64	Phosphorylation	QRCSAGDSHPRLASI HHHCCCCCCHHHHHH	34.18	22817900
70	Phosphorylation	DSHPRLASITNDLAD CCCHHHHHHCCCHHH	34.24	19429919
72	Phosphorylation	HPRLASITNDLADLQ CHHHHHHCCCHHHCC	21.86	19429919
469	Phosphorylation	HALQRPLSLIQGPPG HHHHCCHHHCCCCCC	26.55	22817900
882	Phosphorylation	RKVLVEGSLNNLKES CEEEEEECCHHHHHH	17.89	21082442
1065	Phosphorylation	QQQTGNFSPGNSGPG HHHHCCCCCCCCCCC	35.58	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RENT1_DROME !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RENT1_DROME !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RENT1_DROME !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.