RELN_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RELN_RAT
• UniProt AC: P58751
• Protein Name: Reelin
• Gene Name: Reln
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 3462
• Subcellular Localization: Secreted, extracellular space, extracellular matrix.
• Protein Description: Extracellular matrix serine protease that plays a role in layering of neurons in the cerebral cortex and cerebellum. Regulates microtubule function in neurons and neuronal migration. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation (By similarity)..
• Protein Sequence: MERGCWAPRTLVLAVLLLLLATLRARAATGYYPRFSPFFFLCTHHGELEGDGEQGEVLISLHIAGNPTYYVPGQEYHVTISTSTFFDGLLVTGLYTSTSIQSSQSIGGSSAFGFGIMSDHQFGNQFMCSVVASHVSHLPTTNLSFVWIAPPAGTGCVNFMATATHRGQVIFKDALAQQLCEQGAPTEATAYSHLAEIHSDSVILRDDFDSYHQLELNPNIWAECSNCDTGEQCGTIMHGNAVTFCEPYGPRELTTTYLNTTTASVLQFSIGSGSCRFSYSDPSIIVSYAKNNTADWIQLEKIRAPSNVSTIIHILYLPEDAKGENVQFQWKQDSLHVGEVYEACWALDNILVINSAHRQVILEDSLDPVDTGNWLFFPGATVKHSCQSDGNAIYFHGNEGSQLNFATTRDVDLSTEDIQEQWSEEFESQPTGWDILGAVVGSECGTIESGLSLVFLKDGERKLCTPYMDTTGYGNLRFYFAMGGTCDPGDSHENDVILYAKIEGKKEHIALDTLSYSSYKVPTLVSVVINPELQTPATKFCLRQKNHQGHNQNVWAVDFFHVLPILPSTMSHMIQFSINLGCGTHQPGNSVSLEFSTNHGRSWSLLHTECLPEICAGPHLPHSTIYSSENYSGWNRVTIPLPNAALTRDTRIRWRQTGPILGNMWAIDNVYIGPSCLKFCSGRGQCTRHGCKCDPGFSGPACEMASQTFPMFISESFGSSRLSSYHNFYSIRGAEVSFGCGVLASGKALVFNKDGRRQLITSFLDSSQSRFLQFTLRLGSKSVLSTCRAPDQPGEGVLLHYSYDNGITWKLLEHYSYLNYHEPRIISVELPDDAKQFGIQFRWWQPYHSSQGEDVWAIDEILMTSVLFNSISLDFTNLVEVTQSLGFYLGNIQPYCGHDWTLCFTGDSKLASSMRYVETQSMQIGASYMIQFSLVMGCGQKYTPHMDNQVKLEYSTNHGLTWHLVQDECLPSMPSCQEFTSASIYHASEFTQWRRVTVILPQKTWSGATRFRWSQSYYTAQDEWALDDIYIGQQCPNMCSGHGSCDHGVCRCDQGYQGTECHPEAALPSTIMSDFENPSSWDSDWQEVIGGEVVKPEQGCGVVSSGSSLYFSKAGKRQLVSWDLDTSWVDFVQFYIQIGGESAACNKPDSREEGVLLQYSNNGGIQWHLLAEMYFSDFGKPRFVYLELPAAAKTPCTRFRWWQPVFSGEDYDQWAVDDIIILSEKQKQVIPVVNPTLPQNFYEKPAFDYPINQMSVWLMLANEGMAKNDSFCATTPSAMVFGKSDGDRFAVTRDLTLKPGYVLQFKLNIGCASQFSSTAPVLLQYSHDAGMSWFLVKEGCFPASAGKGCEGNSRELSEPTVYYTGDFEEWTRVTIAIPRSLASSKTRFRWIQESSSQKNVPPFGLDGVYISEPCPSYCSGHGDCISGVCFCDLGYTAAQGTCVSNIPNHSEMFDRFEGKLSPLWYKISGGQVGTGCGTLSDGRSLYFNGLGKREARTVPLDTRNIRLVQFYIQIGSKTSGITCIKPRARNEGLVVQYSNDNGILWHLLRELDFLSFLEPQIISIDLPREAKTPATAFRWWQPQHGKHSAQWALDDVLIGVNDSSQTGFQDKFDGSIDLQANWYRIQGGQVDIDCLSMDTALIFTENIGKPRYAETWDFHVSASSFLQFDMSMGCSKPFSATHSVQLQYSLNNGKDWHPVTEECVPPTIGCVHYTESSTYTSERFQNWRRVTVYLPLATNSPRTRFRWIQANYTMGADAWAIDNVLLASGCPWLCSGRGICDSGRCVCDRGFGGPFCVPVVPLPSILKDDFNGNLHPDLWPEVYGAERGNLNGETIKSGTSLIFKGEGLRMLISRDLDCTNTMYVQFSLRFIAKGTPERSHSILLQSSINGGVTWRLMDEFYFPQTTSILFINVPLPYSAQTNATRFRLWQPYNNGKKEEIWIIDDFIIDGDNLNNPVMLLDTFDFGPREDNWFFYPGGNIGLYCPYSSKGAPEEDSAMVFVSNEIGEHSITTRDLSVNENTIIQFEINVGCSTDSSSADPVRLEFSRDFGATWHLLLPLCYHSSSLVSSLCSTEHHPSSTYYAGTTQGWRREVVHFGKLHLCGSVRFRWYQGFYPAGSQPVTWAIDNVYIGPQCEEMCCGHGSCVNGTKCICDPGYSGPTCKISTKNPDFLKDDFEGQLESDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFVQFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYIALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNISGNTVLEDDFSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIAVNEDSFLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNVECSRYHLQRILVSDTFNKWTRITLPLPAYTRSQATRFRWHQPAPFDKQQTWAIDNVYIGDGCLDMCSGHGRCIQGSCVCDEQWGGLYCDEPETSLPTQLKDNFNRAPSNQNWLTVNGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQFYFMYGCLITPSNRNQGVLLEYSVNGGITWTLLMEIFYDQYSKPGFVNILLPPDAKEIGTRFRWWQPRHDGLDQNDWAIDNVLISGSADQRTVMLDTFSSAPVPQHERSPADAGPVGRIAFDMFMEDKTSVNENWVFHDDCTVERFCDSPDGVMLCGSHDGREVYAVTHDLTPTENWIMQFKISVGCKVPEKIAQNQIHVQFSTDFGVSWSYLVPQCLPADPKCSGTVSQPSVFFPTKGWKRITYPLPESLMGNPVRFRFYQKYSDVQWAIDNFYLGPGCLDNCGGHGDCLKEQCICDPGYSGPHCYLTHTLKTFLKERFDSEEIKPDLWMSLEGGSTCTECGILAENTALYFGGSTVRQAITQDLDLRGAKFLQYWGRIGSENNMTSCHRPVCRKEGVLLDYSKDGGITWTLLHEMDFQKYISVRHDYILLPEGALTNTTRLRWWQPFVISNGLVVSGVERAQWALDNILIGGAEINPSQLVDTFDDEGSSHEENWSFYPNAVRTAGFCGNPSFHLYWPNKKKDKTHNALSSRELIIQPGYMMQFKIVVGCEATSCGDLHSVMLEYTKDARSDSWQLVQTQCLPSSSNSIGCSPFQFHEATIYNAVNSSSWKRITIQLPDHVSSSATQFRWIQKGEETEKQSWAIDHVYIGEACPRLCSGHGYCTTGAVCICDESFQGDDCSVFSHELPSYIKDNFESARVTEANWETIQGGAIGSGCGQLAPYAHGDSLYFNGCQIRQAATKPLDLTRASKIMFVLQIGSTAQTDSCNSDLSGPHTVDKAVLLQYSVNNGITWHVIAQHQPKDFTQAQRVSYNVPLEARMKGVLLRWWQPRHNGTGHDQWALDHVEVVLVSTRKQNYMMNFSRQHGLRHFYNRRRRSLRRYP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
142	N-linked_Glycosylation	VSHLPTTNLSFVWIA HHCCCCCCEEEEEEC	35.84	-
199	Phosphorylation	SHLAEIHSDSVILRD HHHHHHCCCCEEECC	36.92	22673903
201	Phosphorylation	LAEIHSDSVILRDDF HHHHCCCCEEECCCC	17.67	22673903
259	N-linked_Glycosylation	ELTTTYLNTTTASVL CCEEEEECCCCCEEE	25.60	-
291	N-linked_Glycosylation	IIVSYAKNNTADWIQ EEEEEECCCCCCEEE	42.80	-
307	N-linked_Glycosylation	EKIRAPSNVSTIIHI EECCCCCCCCEEEEE	30.60	-
630	N-linked_Glycosylation	STIYSSENYSGWNRV CCEECCCCCCCCCCE	37.91	-
1268	N-linked_Glycosylation	ANEGMAKNDSFCATT HCCCCCCCCCCCCCC	40.39	-
1448	N-linked_Glycosylation	TCVSNIPNHSEMFDR CEEECCCCCHHHHHH	47.74	-
1601	N-linked_Glycosylation	DDVLIGVNDSSQTGF CCEEEECCCCCCCCC	37.93	-
1751	N-linked_Glycosylation	RFRWIQANYTMGADA CEEEECCCCCCCCCE	19.21	-
1922	N-linked_Glycosylation	LPYSAQTNATRFRLW CCCCCCCCCCEEEEE	27.51	-
2146	N-linked_Glycosylation	CGHGSCVNGTKCICD CCCCCCCCCCEEEEC	57.66	-
2270	N-linked_Glycosylation	LQEFLFSNSSNVGRY HHHHHCCCCCCCCEE	41.97	-
2318	N-linked_Glycosylation	DQILIGGNISGNTVL EEEEECCCCCCCCCC	21.75	-
2570	N-linked_Glycosylation	LLVTVDLNLTNAEFI EEEEEECCCCCHHHH	40.11	-
2819	Ubiquitination	FFPTKGWKRITYPLP ECCCCCCEEEEEECC	42.46	-
2900	Phosphorylation	FLKERFDSEEIKPDL HHHHCCCCCCCCCCE	34.12	22673903
2963	N-linked_Glycosylation	GRIGSENNMTSCHRP HCCCCCCCCCCCCCC	30.93	-
3017	N-linked_Glycosylation	LPEGALTNTTRLRWW CCCCCCCCCCCCEEC	40.06	-
3074	N-linked_Glycosylation	EGSSHEENWSFYPNA CCCCCCCCCCCCCCC	36.39	-
3186	N-linked_Glycosylation	ATIYNAVNSSSWKRI EEEHHCCCCCCCCEE	33.49	-
3413	N-linked_Glycosylation	RWWQPRHNGTGHDQW EEECCCCCCCCCCCC	51.50	-
3440	N-linked_Glycosylation	RKQNYMMNFSRQHGL CCCCCCCCHHHHHHH	18.40	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RELN_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RELN_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RELN_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RELN_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.