dbPTM

REI1_CAEEL - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	REI1_CAEEL
UniProt AC	P42171
Protein Name	Guanine nucleotide exchange factor rei-1 {ECO:0000305}
Gene Name	rei-1 {ECO:0000312\|WormBase:C03C10.4}
Organism	Caenorhabditis elegans.
Sequence Length	244
Subcellular Localization	Cytoplasmic granule . Golgi apparatus membrane . Localizes to cytoplasmic granules and to Golgi apparatus membrane in growing oocytes. Co-localizes with rab-11.1 at Golgi apparatus membrane in embryos.
Protein Description	Guanine nucleotide exchange factor for Rab GTPase Rab-11.1. Spatially and temporally regulates the distribution of Rab-11.1 to target membranes during embryogenesis. Plays a role in cytokinesis, probably by targeting rab-11.1 to the cleavage furrows..
Protein Sequence	MTEGDDQLISIRKQLENLNNATDDINSYEMKLETVKKQFCETQLMFNKEMLGIPKKLAKHISKSRQFFDLKSRESEIRRCVQQAAAQFERQKTSVEMAREQVQILHNSLNNNQELDAEKQYVDVIEQQLELVKEAEGECLKAEKCHASRVRDLLQLEMALRKCLEENGSAIKKSRPYYERKEVLTRTMNSQLELMSILEHEVQERKDSYSDSMRALEQISDQIHQERSSQSSLAPSSDAESDSS

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference	Orthologous Protein Cluster
Oops, there are no PTM records of REI1_CAEEL !!

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of REI1_CAEEL !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of REI1_CAEEL !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of REI1_CAEEL !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of REI1_CAEEL !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of REI1_CAEEL

Related Literatures of Post-Translational Modification