REC8_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: REC8_MOUSE
• UniProt AC: Q8C5S7
• Protein Name: Meiotic recombination protein REC8 homolog
• Gene Name: Rec8
• Organism: Mus musculus (Mouse).
• Sequence Length: 591
• Subcellular Localization: Nucleus . Chromosome . Chromosome, centromere . In meiotic chromosomes, localized along axial elements in prophase from the leptotene to diplotene stages. At later prophase stages, diakinesis and metaphase I, localized along interstitial axes of chro
• Protein Description: Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II..
• Protein Sequence: MFYYPNVLQRHTGCFATIWLAATRGSRLVKREYLNVNVVKTCEEILNYVLVRVQPPVAGLPRPRFSLYLSAQLQIGVIRVYFQQCQYLVEDIQHILEHLHRAQLRIRIDMEEADLPSLLLPNCLAMMETLEDAPEPFFGKMSVDPRLPSPFDIPQIRHLLEAATPEKTRKETLPEATPDPRKPDRTLATVQSPEVITLQEAEPIRMLQIEGEQDLPEISRGDLELLIAEKDDAILLEERQRGRLLRQRRASLPLDESREEPRALEGAGLVSALSPPAPAQVEGIQEALPGQVFPPEVQKMTGWEPGALLTEVTPPQELRLPAPPSTEKRLPSLQRPLPRRHRRRQLLFWDKETQISREKFEEQLQTGAHCWEYPVAQPPKRMLTSPAELFRTPTLSGWLPPELLGLWTHCAQVPQRMLRQRPQLETEETVEEERAADEEERRKTEALSEIEVLREAQEPSGPLMLSSELSLEAAEDEKSRTSLIPPEWWAWSEEGQPEPPALPMLPELPEVPMEMPPRPELSSEAVLRAVALKLQANKELDFSSLVPPLSPRKLASRVFYLLLVLSTQKILLVEQQKPYGPLLIRPGPKFP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
149	Phosphorylation	SVDPRLPSPFDIPQI CCCCCCCCCCCHHHH	42.67	22817900
164	Phosphorylation	RHLLEAATPEKTRKE HHHHHHCCCHHHHHH	38.74	22817900
186	Phosphorylation	DPRKPDRTLATVQSP CCCCCCCCEEEECCC	28.29	25293948
189	Phosphorylation	KPDRTLATVQSPEVI CCCCCEEEECCCCEE	23.38	25293948
192	Phosphorylation	RTLATVQSPEVITLQ CCEEEECCCCEEECE	20.77	25293948
251	Phosphorylation	LLRQRRASLPLDESR HHHHHHHCCCCCCCC	28.80	28066266
271	Phosphorylation	LEGAGLVSALSPPAP HCCCCHHHHCCCCCC	28.65	25293948
274	Phosphorylation	AGLVSALSPPAPAQV CCHHHHCCCCCCHHH	28.67	25293948

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of REC8_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of REC8_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of REC8_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of REC8_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.