RBP1_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBP1_RAT
• UniProt AC: Q62796
• Protein Name: RalA-binding protein 1
• Gene Name: Ralbp1
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 647
• Subcellular Localization: Membrane; Peripheral membrane protein. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, spindle pole. Cytosolic protein that transiently associates with the mitotic spindle poles in early prophase, and dissociates from them after completion of mitosis.
• Protein Description: Can activate specifically hydrolysis of GTP bound to RAC1 and CDC42, but not RALA. Mediates ATP-dependent transport of S-(2,4-dinitrophenyl)-glutathione (DNP-SG) and doxorubicin (DOX) and is the major ATP-dependent transporter of glutathione conjugates of electrophiles (GS-E) and DOX in erythrocytes. Can catalyze transport of glutathione conjugates and xenobiotics, and may contribute to the multidrug resistance phenomenon. Serves as a scaffold protein that brings together proteins forming an endocytotic complex during interphase and also with CDK1 to switch off endocytosis, One of its substrates would be EPN1/Epsin (By similarity). Involved in the assembly and function of the mitotic apparatus..
• Protein Sequence: MTECFLPPTSSPSEHRRAEHGSGLTRTPSSEEISPTKFPELYRTGEPSPPHDILHEPPDIVSDDEKDHGKKKGKFKKKEKRTEGYVAFQEDSSGDEAESPSKMKRSKGIHVFKKPSFSKKKEKDFKIKEKPKEEKHKEEKHKEEKHKEKKCKDFTAADVVKQWKEKKKKKKPTQEPEVPQTDAPSLRPIFGAPFADAVERTMMYDGIRLPAVFRECVDYMEKHGMKCEGIYRVSGIKSKVDELKAAYDREESPNLEEYEPNTVASLLKQYLRDLPENLLTKELMPRFEEACGRTTEVEKVQEFQRLLRELPEYNHLLLSWLIVHMDHVIAKELETKMNIQNISIVLSPTVQISNRVLYVLFTHVQELFGTVLLKQVTRPLRWSNMATMPTLPETQAGIKEEIRRQEFLLNCLHRDLQGGIKDFSKEERLWEVQRILTALKRKLREAKRQECETKIAQEIASLSKEDVSKEETNENEEVINILLAQENEILTEQEELLAMEQFLRRQIASEKEEIDRLRAEIAEIQSRQHGRSETEEYSSDSESESEDEEELQIILEDLQRQNEELEIKNNHLNQAVHEEREAIVELRVQLRLLQMLRAKSEQQLQEEEEPERRGGTGPLPCEGVLEVRAAKEQAKPSPSKDRKETPI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MTECFLPPT ------CCCCCCCCC	41.27	-
9	Phosphorylation	TECFLPPTSSPSEHR CCCCCCCCCCHHHHC	39.64	27097102
10	Phosphorylation	ECFLPPTSSPSEHRR CCCCCCCCCHHHHCC	46.13	27097102
11	Phosphorylation	CFLPPTSSPSEHRRA CCCCCCCCHHHHCCH	34.62	23589303
13	Phosphorylation	LPPTSSPSEHRRAEH CCCCCCHHHHCCHHC	48.24	27097102
22	Phosphorylation	HRRAEHGSGLTRTPS HCCHHCCCCCCCCCC	32.32	23984901
25	Phosphorylation	AEHGSGLTRTPSSEE HHCCCCCCCCCCCCC	35.70	27097102
27	Phosphorylation	HGSGLTRTPSSEEIS CCCCCCCCCCCCCCC	23.45	27097102
29	Phosphorylation	SGLTRTPSSEEISPT CCCCCCCCCCCCCCC	50.17	23712012
30	Phosphorylation	GLTRTPSSEEISPTK CCCCCCCCCCCCCCC	40.21	21738781
34	Phosphorylation	TPSSEEISPTKFPEL CCCCCCCCCCCCCHH	29.78	27097102
36	Phosphorylation	SSEEISPTKFPELYR CCCCCCCCCCCHHHC	38.23	28432305
44	Phosphorylation	KFPELYRTGEPSPPH CCCHHHCCCCCCCCC	32.13	28432305
48	Phosphorylation	LYRTGEPSPPHDILH HHCCCCCCCCCCCCC	46.92	30240740
62	Phosphorylation	HEPPDIVSDDEKDHG CCCCCCCCCCCCCCC	39.41	28432305
92	Phosphorylation	YVAFQEDSSGDEAES EEEEECCCCCCCCCC	35.15	-
93	Phosphorylation	VAFQEDSSGDEAESP EEEECCCCCCCCCCH	63.69	28689409
461	Phosphorylation	KIAQEIASLSKEDVS HHHHHHHHCCHHHCC	38.55	28432305
463	Phosphorylation	AQEIASLSKEDVSKE HHHHHHCCHHHCCHH	31.35	30411139
468	Phosphorylation	SLSKEDVSKEETNEN HCCHHHCCHHHCCCC	46.82	28432305
600	Phosphorylation	LQMLRAKSEQQLQEE HHHHHHHHHHHHHHH	39.39	28432305
637	Phosphorylation	AKEQAKPSPSKDRKE HHHHCCCCCCCCCCC	40.89	28432305
639	Phosphorylation	EQAKPSPSKDRKETP HHCCCCCCCCCCCCC	52.07	28432305

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBP1_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBP1_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBP1_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RBP1_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.