RBL2B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RBL2B_HUMAN
• UniProt AC: Q9UNT1
• Protein Name: Rab-like protein 2B
• Gene Name: RABL2B
• Organism: Homo sapiens (Human).
• Sequence Length: 228
• Subcellular Localization: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole . Cytoplasm, cytoskeleton, cilium basal body . Cytoplasm . Localizes on the mother centriole. Localizes slightly apical to the subdistal appendage, but below the distal app
• Protein Description: Small GTPase required for ciliation. Activated in a guanine nucleotide exchange factor (GEF)-independent manner via its intrinsic GDP for GTP nucleotide exchange ability. [PubMed: 28625565 Involved in ciliary assembly by binding the intraflagellar transport (IFT) complex B from the large pool pre-docked at the base of the cilium and thus triggers its entry into the cilia]
• Protein Sequence: MAEDKTKPSELDQGKYDADDNVKIICLGDSAVGKSKLMERFLMDGFQPQQLSTYALTLYKHTATVDGRTILVDFWDTAGQERFQSMHASYYHKAHACIMVFDVQRKVTYRNLSTWYTELREFRPEIPCIVVANKIDDINVTQKSFNFAKKFSLPLYFVSAADGTNVVKLFNDAIRLAVSYKQNSQDFMDEIFQELENFSLEQEEEDVPDQEQSSSIETPSEEAASPHS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Ubiquitination	YDADDNVKIICLGDS CCCCCCEEEEEECCC	32.38	-
23	Acetylation	YDADDNVKIICLGDS CCCCCCEEEEEECCC	32.38	-
26	S-nitrosylation	DDNVKIICLGDSAVG CCCEEEEEECCCHHC	3.86	24105792
30	Phosphorylation	KIICLGDSAVGKSKL EEEEECCCHHCHHHH	24.05	30622161
34	Acetylation	LGDSAVGKSKLMERF ECCCHHCHHHHHHHH	37.51	-
34	Ubiquitination	LGDSAVGKSKLMERF ECCCHHCHHHHHHHH	37.51	-
35	Acetylation	GDSAVGKSKLMERFL CCCHHCHHHHHHHHH	25.70	-
52	Phosphorylation	GFQPQQLSTYALTLY CCCHHHHHHHHHEEE	18.29	-
57	Phosphorylation	QLSTYALTLYKHTAT HHHHHHHEEEEEEEE	21.62	-
59	Phosphorylation	STYALTLYKHTATVD HHHHHEEEEEEEEEC	8.76	-
85	Phosphorylation	AGQERFQSMHASYYH HCHHHHHHHHHHHHH	15.15	23663014
89	Phosphorylation	RFQSMHASYYHKAHA HHHHHHHHHHHHCCE	16.14	23663014
90	Phosphorylation	FQSMHASYYHKAHAC HHHHHHHHHHHCCEE	15.46	23663014
91	Phosphorylation	QSMHASYYHKAHACI HHHHHHHHHHCCEEE	8.37	23663014
108	Phosphorylation	FDVQRKVTYRNLSTW EEEECHHCCCCHHHH	21.57	24719451
141	Phosphorylation	KIDDINVTQKSFNFA CCCCCCCCHHHCCHH	26.28	20058876
143	Ubiquitination	DDINVTQKSFNFAKK CCCCCCHHHCCHHHH	47.88	-
144	Phosphorylation	DINVTQKSFNFAKKF CCCCCHHHCCHHHHC	18.66	-
144 (in isoform 2)	Ubiquitination	-	18.66	21890473
149	Ubiquitination	QKSFNFAKKFSLPLY HHHCCHHHHCCCCEE	50.65	-
150	Ubiquitination	KSFNFAKKFSLPLYF HHCCHHHHCCCCEEE	36.43	-
150 (in isoform 1)	Ubiquitination	-	36.43	21890473
151 (in isoform 2)	Ubiquitination	-	10.00	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RBL2B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RBL2B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RBL2B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
CEP19_HUMAN	CEP19	physical	16189514
RASEF_HUMAN	RASEF	physical	26186194
IDI2_HUMAN	IDI2	physical	26186194
RASEF_HUMAN	RASEF	physical	28514442
IDI2_HUMAN	IDI2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.