RB11A_RAT - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: RB11A_RAT
• UniProt AC: P62494
• Protein Name: Ras-related protein Rab-11A
• Gene Name: Rab11a
• Organism: Rattus norvegicus (Rat).
• Sequence Length: 216
• Subcellular Localization: Cell membrane ; Lipid-anchor . Recycling endosome membrane ; Lipid-anchor . Cleavage furrow . Cytoplasmic vesicle, phagosome . Translocates with RAB11FIP2 from the vesicles of the endocytic recycling compartment (ERC) to the plasma membrane. Localize
• Protein Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab regulates endocytic recycling. Acts as a major regulator of membrane delivery during cytokinesis. Together with MYO5B and RAB8A participates in epithelial cell polarization. Together with RAB3IP, RAB8A, the exocyst complex, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis. Together with MYO5B participates in CFTR trafficking to the plasma membrane and TF (Transferrin) recycling in nonpolarized cells. Required in a complex with MYO5B and RAB11FIP2 for the transport of NPC1L1 to the plasma membrane. Participates in the sorting and basolateral transport of CDH1 from the Golgi apparatus to the plasma membrane. Regulates the recycling of FCGRT (receptor of Fc region of monomeric Ig G) to basolateral membranes. May also play a role in melanosome transport and release from melanocytes..
• Protein Sequence: MGTRDDEYDYLFKVVLIGDSGVGKSNLLSRFTRNEFNLESKSTIGVEFATRSIQVDGKTIKAQIWDTAGQERYRAITSAYYRGAVGALLVYDIAKHLTYENVERWLKELRDHADSNIVIMLVGNKSDLRHLRAVPTDEARAFAEKNGLSFIETSALDSTNVEAAFQTILTEIYRIVSQKQMSDRRENDMSPSNNVVPIHVPPTTENKPKVQCCQNI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MGTRDDEYD ------CCCCHHHHC	29.47	-
3	Phosphorylation	-----MGTRDDEYDY -----CCCCHHHHCE	29.62	22673903
8	Phosphorylation	MGTRDDEYDYLFKVV CCCCHHHHCEEEEEE	19.51	22673903
10	Phosphorylation	TRDDEYDYLFKVVLI CCHHHHCEEEEEEEE	17.09	22673903
42	Phosphorylation	EFNLESKSTIGVEFA CCCCCCCCEEEEEEE	34.24	22108457
43	Phosphorylation	FNLESKSTIGVEFAT CCCCCCCEEEEEEEE	26.03	22108457
58	Acetylation	RSIQVDGKTIKAQIW EEEEECCEEEEEEEE	42.48	1208800691
61	Acetylation	QVDGKTIKAQIWDTA EECCEEEEEEEECCC	39.20	-
77	Phosphorylation	QERYRAITSAYYRGA HHHHHHHHHHHHHHH	13.30	27097102
78	Phosphorylation	ERYRAITSAYYRGAV HHHHHHHHHHHHHHH	14.25	27097102
80	Phosphorylation	YRAITSAYYRGAVGA HHHHHHHHHHHHHHH	8.08	27097102
81	Phosphorylation	RAITSAYYRGAVGAL HHHHHHHHHHHHHHH	11.42	28689409
190	Phosphorylation	DRRENDMSPSNNVVP CCCCCCCCCCCCEEC	28.21	27097102
192	Phosphorylation	RENDMSPSNNVVPIH CCCCCCCCCCEECCC	33.46	27097102
212	Geranylgeranylation	ENKPKVQCCQNI--- CCCCCCEECCCC---	2.63	-
213	Methylation	NKPKVQCCQNI---- CCCCCEECCCC----	1.62	-
213	Geranylgeranylation	NKPKVQCCQNI---- CCCCCEECCCC----	1.62	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of RB11A_RAT !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of RB11A_RAT !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of RB11A_RAT !!

Protein-Protein Interaction

Oops, there are no PPI records of RB11A_RAT !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.