dbPTM

RASL3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RASL3_HUMAN
UniProt AC	Q86YV0
Protein Name	RAS protein activator like-3
Gene Name	RASAL3
Organism	Homo sapiens (Human).
Sequence Length	1011
Subcellular Localization	Cytoplasm . Cytoplasm, cell cortex .
Protein Description	Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down-stream ERK signaling pathway..
Protein Sequence	MDPPSPSRTSQTQPTATSPLTSYRWHTGGGGEKAAGGFRWGRFAGWGRALSHQEPMVSTQPAPRSIFRRVLSAPPKESRTSRLRLSKALWGRHKNPPPEPDPEPEQEAPELEPEPELEPPTPQIPEAPTPNVPVWDIGGFTLLDGKLVLLGGEEEGPRRPRVGSASSEGSIHVAMGNFRDPDRMPGKTEPETAGPNQVHNVRGLLKRLKEKKKARLEPRDGPPSALGSRESLATLSELDLGAERDVRIWPLHPSLLGEPHCFQVTWTGGSRCFSCRSAAERDRWIEDLRRQFQPTQDNVEREETWLSVWVHEAKGLPRAAAGAPGVRAELWLDGALLARTAPRAGPGQLFWAERFHFEALPPARRLSLRLRGLGPGSAVLGRVALALEELDAPRAPAAGLERWFPLLGAPAGAALRARIRARRLRVLPSERYKELAEFLTFHYARLCGALEPALPAQAKEELAAAMVRVLRATGRAQALVTDLGTAELARCGGREALLFRENTLATKAIDEYMKLVAQDYLQETLGQVVRRLCASTEDCEVDPSKCPASELPEHQARLRNSCEEVFETIIHSYDWFPAELGIVFSSWREACKERGSEVLGPRLVCASLFLRLLCPAILAPSLFGLAPDHPAPGPARTLTLIAKVIQNLANRAPFGEKEAYMGFMNSFLEEHGPAMQCFLDQVAMVDVDAAPSGYQGSGDLALQLAVLHAQLCTIFAELDQTTRDTLEPLPTILRAIEEGQPVLVSVPMRLPLPPAQVHSSLSAGEKPGFLAPRDLPKHTPLISKSQSLRSVRRSESWARPRPDEERPLRRPRPVQRTQSVPVRRPARRRQSAGPWPRPKGSLSMGPAPRARPWTRDSASLPRKPSVPWQRQMDQPQDRNQALGTHRPVNKLAELQCEVAALREEQKVLSRLVESLSTQIRALTEQQEQLRGQLQDLDSRLRAGSSEFDSEHNLTSNEGHSLKNLEHRLNEMERTQAQLRDAVQSLQLSPRTRGSWSQPQPLKAPCLNGDTT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MDPPSPSRTSQT ---CCCCCCCCCCCC	40.68	23401153
7	Phosphorylation	-MDPPSPSRTSQTQP -CCCCCCCCCCCCCC	53.15	23401153
9	Phosphorylation	DPPSPSRTSQTQPTA CCCCCCCCCCCCCCC	29.53	28450419
10	Phosphorylation	PPSPSRTSQTQPTAT CCCCCCCCCCCCCCC	30.07	28450419
12	Phosphorylation	SPSRTSQTQPTATSP CCCCCCCCCCCCCCC	35.96	28450419
15	Phosphorylation	RTSQTQPTATSPLTS CCCCCCCCCCCCCCE	32.52	26657352
17	Phosphorylation	SQTQPTATSPLTSYR CCCCCCCCCCCCEEC	33.10	23401153
18	Phosphorylation	QTQPTATSPLTSYRW CCCCCCCCCCCEECE	18.56	23401153
21	Phosphorylation	PTATSPLTSYRWHTG CCCCCCCCEECEECC	27.39	30108239
22	Phosphorylation	TATSPLTSYRWHTGG CCCCCCCEECEECCC	22.00	28450419
23	Phosphorylation	ATSPLTSYRWHTGGG CCCCCCEECEECCCC	16.70	28450419
27	Phosphorylation	LTSYRWHTGGGGEKA CCEECEECCCCCCCC	30.48	26074081
33	Ubiquitination	HTGGGGEKAAGGFRW ECCCCCCCCCCCCCC	46.97	-
51	Phosphorylation	AGWGRALSHQEPMVS CCCCCCCCCCCCCCC	23.34	23401153
58	Phosphorylation	SHQEPMVSTQPAPRS CCCCCCCCCCCCCHH	18.31	25072903
59	Phosphorylation	HQEPMVSTQPAPRSI CCCCCCCCCCCCHHH	27.45	28450419
65	Phosphorylation	STQPAPRSIFRRVLS CCCCCCHHHHHHHHC	25.64	28634298
72	Phosphorylation	SIFRRVLSAPPKESR HHHHHHHCCCCCCCH	35.55	23401153
78	Phosphorylation	LSAPPKESRTSRLRL HCCCCCCCHHHHHHH	47.16	-
80	Phosphorylation	APPKESRTSRLRLSK CCCCCCHHHHHHHHH	27.72	22210691
81	Phosphorylation	PPKESRTSRLRLSKA CCCCCHHHHHHHHHH	28.36	22210691
164	Phosphorylation	PRRPRVGSASSEGSI CCCCCCCCCCCCCCE	23.32	20164059
166	Phosphorylation	RPRVGSASSEGSIHV CCCCCCCCCCCCEEE	30.53	28787133
167	Phosphorylation	PRVGSASSEGSIHVA CCCCCCCCCCCEEEE	45.77	23401153
170	Phosphorylation	GSASSEGSIHVAMGN CCCCCCCCEEEEECC	12.89	28464451
188	Phosphorylation	PDRMPGKTEPETAGP CCCCCCCCCCCCCCC	63.79	29449344
192	Phosphorylation	PGKTEPETAGPNQVH CCCCCCCCCCCCHHH	47.86	29449344
224	Phosphorylation	EPRDGPPSALGSRES CCCCCCCCCCCCHHH	38.98	22115753
228	Phosphorylation	GPPSALGSRESLATL CCCCCCCCHHHHHHH	33.45	23401153
231	Phosphorylation	SALGSRESLATLSEL CCCCCHHHHHHHHHC	23.38	22115753
234	Phosphorylation	GSRESLATLSELDLG CCHHHHHHHHHCCCC	35.79	22115753
236	Phosphorylation	RESLATLSELDLGAE HHHHHHHHHCCCCCC	31.58	30576142
295	Phosphorylation	LRRQFQPTQDNVERE HHHHHCCCCCCCHHH	37.46	29978859
304	Phosphorylation	DNVEREETWLSVWVH CCCHHHHHHHHHHHH	27.27	29978859
307	Phosphorylation	EREETWLSVWVHEAK HHHHHHHHHHHHHHC	12.90	29978859
367	Phosphorylation	LPPARRLSLRLRGLG CCHHHHHHHHHCCCC	15.05	26074081
377	Phosphorylation	LRGLGPGSAVLGRVA HCCCCCCHHHHHHHH	20.52	27067055
429	Phosphorylation	RRLRVLPSERYKELA HHHCCCCHHHHHHHH	30.46	24719451
459	Ubiquitination	PALPAQAKEELAAAM CCCCHHHHHHHHHHH	39.37	-
473	Phosphorylation	MVRVLRATGRAQALV HHHHHHHHCCHHHHH	22.29	23532336
481	Phosphorylation	GRAQALVTDLGTAEL CCHHHHHCCHHHHHH	26.76	23532336
506	Phosphorylation	FRENTLATKAIDEYM EECCHHHHHHHHHHH	24.91	24275569
507	Ubiquitination	RENTLATKAIDEYMK ECCHHHHHHHHHHHH	37.42	29967540
512	Phosphorylation	ATKAIDEYMKLVAQD HHHHHHHHHHHHHHH	8.87	-
535	Phosphorylation	VVRRLCASTEDCEVD HHHHHHCCCCCCCCC	31.19	29116813
536	Phosphorylation	VRRLCASTEDCEVDP HHHHHCCCCCCCCCH	19.81	29116813
544	Phosphorylation	EDCEVDPSKCPASEL CCCCCCHHHCCHHHC	42.29	29116813
545	Ubiquitination	DCEVDPSKCPASELP CCCCCHHHCCHHHCH	50.02	-
643	Ubiquitination	RTLTLIAKVIQNLAN HHHHHHHHHHHHHHH	32.64	-
748	Sulfoxidation	PVLVSVPMRLPLPPA CEEEEEECCCCCCHH	6.87	21406390
759	Phosphorylation	LPPAQVHSSLSAGEK CCHHHCCCCCCCCCC	33.83	28122231
760	Phosphorylation	PPAQVHSSLSAGEKP CHHHCCCCCCCCCCC	16.09	28122231
762	Phosphorylation	AQVHSSLSAGEKPGF HHCCCCCCCCCCCCC	35.85	28122231
777	Ubiquitination	LAPRDLPKHTPLISK CCCCCCCCCCCCCCC	68.36	29967540
779	Phosphorylation	PRDLPKHTPLISKSQ CCCCCCCCCCCCCCH	26.39	27080861
783	Phosphorylation	PKHTPLISKSQSLRS CCCCCCCCCCHHHHH	33.66	27080861
785	Phosphorylation	HTPLISKSQSLRSVR CCCCCCCCHHHHHHH	20.43	27080861
787	Phosphorylation	PLISKSQSLRSVRRS CCCCCCHHHHHHHCC	32.61	23401153
790	Phosphorylation	SKSQSLRSVRRSESW CCCHHHHHHHCCCCC	25.85	23401153
794	Phosphorylation	SLRSVRRSESWARPR HHHHHHCCCCCCCCC	25.97	27080861
796	Phosphorylation	RSVRRSESWARPRPD HHHHCCCCCCCCCCC	27.55	23401153
817	Phosphorylation	RPRPVQRTQSVPVRR CCCCCCCCCCCCCCC	14.22	26657352
819	Phosphorylation	RPVQRTQSVPVRRPA CCCCCCCCCCCCCCC	27.98	23401153
831	Phosphorylation	RPARRRQSAGPWPRP CCCCCCCCCCCCCCC	33.12	23401153
841	Phosphorylation	PWPRPKGSLSMGPAP CCCCCCCCCCCCCCC	24.32	23401153
843	Phosphorylation	PRPKGSLSMGPAPRA CCCCCCCCCCCCCCC	24.32	23401153
854	Phosphorylation	APRARPWTRDSASLP CCCCCCCCCCCCCCC	27.55	30108239
857	Phosphorylation	ARPWTRDSASLPRKP CCCCCCCCCCCCCCC	19.23	23401153
859	Phosphorylation	PWTRDSASLPRKPSV CCCCCCCCCCCCCCC	42.74	23401153
865	Phosphorylation	ASLPRKPSVPWQRQM CCCCCCCCCCHHHCC	43.79	23401153
884	Phosphorylation	DRNQALGTHRPVNKL HHHHHCCCCCCHHHH	18.63	30576142
938	Phosphorylation	GQLQDLDSRLRAGSS HHHHHHHHHHHHCCC	40.28	19690332
944	Phosphorylation	DSRLRAGSSEFDSEH HHHHHHCCCCCCCCC	26.21	23401153
945	Phosphorylation	SRLRAGSSEFDSEHN HHHHHCCCCCCCCCC	41.17	23401153
949	Phosphorylation	AGSSEFDSEHNLTSN HCCCCCCCCCCCCCC	46.18	23401153
954	Phosphorylation	FDSEHNLTSNEGHSL CCCCCCCCCCCCCHH	34.52	28450419
955	Phosphorylation	DSEHNLTSNEGHSLK CCCCCCCCCCCCHHH	35.73	28450419
960	Phosphorylation	LTSNEGHSLKNLEHR CCCCCCCHHHHHHHH	52.47	28450419
984	Phosphorylation	QLRDAVQSLQLSPRT HHHHHHHHHCCCCCC	16.10	26657352
988	Phosphorylation	AVQSLQLSPRTRGSW HHHHHCCCCCCCCCC	10.20	23401153
991	Phosphorylation	SLQLSPRTRGSWSQP HHCCCCCCCCCCCCC	42.65	23401153
994	Phosphorylation	LSPRTRGSWSQPQPL CCCCCCCCCCCCCCC	21.92	22115753
996	Phosphorylation	PRTRGSWSQPQPLKA CCCCCCCCCCCCCCC	33.41	28450419
1010	Phosphorylation	APCLNGDTT------ CCCCCCCCC------	35.48	28450419
1011	Phosphorylation	PCLNGDTT------- CCCCCCCC-------	41.16	28450419

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RASL3_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RASL3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RASL3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RASL3_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RASL3_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-18; SER-51; SER-164;SER-167; SER-231 AND SER-988, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-988, AND MASSSPECTROMETRY.	19369195 [Abstract]