RASL2_HUMAN - dbPTM
RASL2_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID RASL2_HUMAN
UniProt AC O43374
Protein Name Ras GTPase-activating protein 4
Gene Name RASA4
Organism Homo sapiens (Human).
Sequence Length 803
Subcellular Localization Cytoplasm, cytosol . Cell membrane
Peripheral membrane protein . Localized to the cytosol as a result of its lack of phosphoinositide binding activity. Upon agonist-stimulated calcium mobilization, utilizes the C2A and C2B domains to associate with
Protein Description Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis..
Protein Sequence MAKRSSLYIRIVEGKNLPAKDITGSSDPYCIVKVDNEPIIRTATVWKTLCPFWGEEYQVHLPPTFHAVAFYVMDEDALSRDDVIGKVCLTRDTIASHPKGFSGWAHLTEVDPDEEVQGEIHLRLEVWPGARACRLRCSVLEARDLAPKDRNGTSDPFVRVRYKGRTRETSIVKKSCYPRWNETFEFELQEGAMEALCVEAWDWDLVSRNDFLGKVVIDVQRLRVVQQEEGWFRLQPDQSKSRRHDEGNLGSLQLEVRLRDETVLPSSYYQPLVHLLCHEVKLGMQGPGQLIPLIEETTSTECRQDVATNLLKLFLGQGLAKDFLDLLFQLELSRTSETNTLFRSNSLASKSMESFLKVAGMQYLHGVLGPIINKVFEEKKYVELDPSKVEVKDVGCSGLHRPQTEAEVLEQSAQTLRAHLGALLSALSRSVRACPAVVRATFRQLFRRVRERFPGAQHENVPFIAVTSFLCLRFFSPAIMSPKLFHLRERHADARTSRTLLLLAKAVQNVGNMDTPASRAKEAWMEPLQPTVRQGVAQLKDFITKLVDIEEKDELDLQRTLSLQAPPVKEGPLFIHRTKGKGPLMSSSFKKLYFSLTTEALSFAKTPSSKKSALIKLANIRAAEKVEEKSFGGSHVMQVIYTDDAGRPQTAYLQCKCVNELNQWLSALRKVSINNTGLLGSYHPGVFRGDKWSCCHQKEKTGQGCDKTRSRVTLQEWNDPLDHDLEAQLIYRHLLGVEAMLWERHRELSGGAEAGTVPTSPGKVPEDSLARLLRVLQDLREAHSSSPAGSPPSEPNCLLELQT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
8PhosphorylationMAKRSSLYIRIVEGK
CCCCCCEEEEEECCC		7.0724719451
33UbiquitinationSDPYCIVKVDNEPII
CCCEEEEEECCCCEE		24.7829967540
93PhosphorylationKVCLTRDTIASHPKG
EEECCCHHHHCCCCC		18.36-
96PhosphorylationLTRDTIASHPKGFSG
CCCHHHHCCCCCCCC		36.15-
175PhosphorylationETSIVKKSCYPRWNE
CEEEEEECCCCCCCC		17.1124719451
239PhosphorylationFRLQPDQSKSRRHDE
EECCCCCCCCCCCCC		39.7223403867
241PhosphorylationLQPDQSKSRRHDEGN
CCCCCCCCCCCCCCC		39.5323403867
312UbiquitinationDVATNLLKLFLGQGL
HHHHHHHHHHHCCCH		40.12-
335PhosphorylationFQLELSRTSETNTLF
HHHHHCCCCCCCHHH		27.78-
354PhosphorylationLASKSMESFLKVAGM
HHHHHHHHHHHHHHH		27.5124719451
381PhosphorylationKVFEEKKYVELDPSK
HHHHHCCCEECCCCC		15.3819664994
387PhosphorylationKYVELDPSKVEVKDV
CCEECCCCCEEEEEC		49.3419664994
388UbiquitinationYVELDPSKVEVKDVG
CEECCCCCEEEEECC		48.0423000965
392UbiquitinationDPSKVEVKDVGCSGL
CCCCEEEEECCCCCC		32.9423000965
425PhosphorylationAHLGALLSALSRSVR
HHHHHHHHHHHHHHH		28.19-
428PhosphorylationGALLSALSRSVRACP
HHHHHHHHHHHHHCH		23.40-
476PhosphorylationFLCLRFFSPAIMSPK
HHHHHHHCHHHHCHH		15.65-
481PhosphorylationFFSPAIMSPKLFHLR
HHCHHHHCHHHHHHH		16.87-
505UbiquitinationRTLLLLAKAVQNVGN
HHHHHHHHHHHHHCC		49.4023503661
515PhosphorylationQNVGNMDTPASRAKE
HHHCCCCCCHHHHHH		15.24-
518PhosphorylationGNMDTPASRAKEAWM
CCCCCCHHHHHHHHH		33.69-
521UbiquitinationDTPASRAKEAWMEPL
CCCHHHHHHHHHCCC		47.0229967540
545UbiquitinationQLKDFITKLVDIEEK
HHHHHHHHHCCCCHH		41.5229967540
560PhosphorylationDELDLQRTLSLQAPP
CCCCHHHHHCCCCCC		14.0326437602
562PhosphorylationLDLQRTLSLQAPPVK
CCHHHHHCCCCCCCC		20.1630108239
569UbiquitinationSLQAPPVKEGPLFIH
CCCCCCCCCCCEEEE		63.8330230243
586PhosphorylationKGKGPLMSSSFKKLY
CCCCCCCCCCHHHHH		30.4328857561
587PhosphorylationGKGPLMSSSFKKLYF
CCCCCCCCCHHHHHH		26.3128857561
588PhosphorylationKGPLMSSSFKKLYFS
CCCCCCCCHHHHHHC		33.5025849741
595PhosphorylationSFKKLYFSLTTEALS
CHHHHHHCCHHHHHH		15.96-
609PhosphorylationSFAKTPSSKKSALIK
HCCCCCCCHHHHHHH		45.3530576142
612PhosphorylationKTPSSKKSALIKLAN
CCCCCHHHHHHHHHH		31.8530576142
713PhosphorylationDKTRSRVTLQEWNDP
CCCCCCEEEECCCCC		22.9318691976
717UbiquitinationSRVTLQEWNDPLDHD
CCEEEECCCCCCCCC		11.1023503661
749PhosphorylationWERHRELSGGAEAGT
HHHHHHHCCCCCCCC		30.3523312004
756PhosphorylationSGGAEAGTVPTSPGK
CCCCCCCCCCCCCCC		30.2930108239
759PhosphorylationAEAGTVPTSPGKVPE
CCCCCCCCCCCCCCH		43.1230266825
760PhosphorylationEAGTVPTSPGKVPED
CCCCCCCCCCCCCHH		26.1130266825
763UbiquitinationTVPTSPGKVPEDSLA
CCCCCCCCCCHHHHH		58.9823503661
768PhosphorylationPGKVPEDSLARLLRV
CCCCCHHHHHHHHHH		23.4430108239
790PhosphorylationHSSSPAGSPPSEPNC
HHCCCCCCCCCCCCC		35.4329116813
793PhosphorylationSPAGSPPSEPNCLLE
CCCCCCCCCCCCEEE		69.9029116813
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of RASL2_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of RASL2_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of RASL2_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of RASL2_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of RASL2_HUMAN

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Related Literatures of Post-Translational Modification

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