dbPTM

RAE1L_MOUSE - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	RAE1L_MOUSE
UniProt AC	Q8C570
Protein Name	mRNA export factor
Gene Name	Rae1
Organism	Mus musculus (Mouse).
Sequence Length	368
Subcellular Localization	Cytoplasm . Nucleus . Cytoplasm, cytoskeleton, spindle pole . Recruited from interphase nuclei to spindle MTs during mitosis.
Protein Description	Plays a role in mitotic bipolar spindle formation. Binds mRNA. May function in nucleocytoplasmic transport and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton..
Protein Sequence	MSLFGSTSGFGTGGTSMFGSTTTDNHNPMKDIEVTSSPDDSIGCLSFSPPTLPGNFLIAGSWANDVRCWEVQDSGQTIPKAQQMHTGPVLDVCWSDDGSKVFTASCDKTAKMWDLNSNQAIQIAQHDAPVKTIHWIKAPNYSCVMTGSWDKTLKFWDTRSSNPMMVLQLPERCYCADVIYPMAVVATAERGLIVYQLENQPSEFRRIESPLKHQHRCVAIFKDKQNKPTGFALGSIEGRVAIHYINPPNPAKDNFTFKCHRSNGTNTSAPQDIYAVNGIAFHPVHGTLATVGSDGRFSFWDKDARTKLKTSEQLDQPIAACCFNHNGNIFAYASSYDWSKGHEFYNPQKKNYIFLRNAAEELKPRNKK

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
106	Glutathionylation	SKVFTASCDKTAKMW CEEEEEECCCCCCEE	6.04	24333276
209	Phosphorylation	SEFRRIESPLKHQHR HHHHCCCCCCCCCCE	32.91	24719451
229	Phosphorylation	KDKQNKPTGFALGSI ECCCCCCCCEEEEEE	46.68	-
252	Ubiquitination	INPPNPAKDNFTFKC ECCCCCCCCCEEEEE	55.23	-
274	Phosphorylation	TSAPQDIYAVNGIAF CCCCCEEEEECCEEE	16.88	22817900
345	Phosphorylation	WSKGHEFYNPQKKNY CCCCCCCCCCCCCCE	23.97	29514104
352	Phosphorylation	YNPQKKNYIFLRNAA CCCCCCCEEEECCHH	11.26	29514104
363	Ubiquitination	RNAAEELKPRNKK-- CCHHHHHCCCCCC--	45.25	27667366
363	Acetylation	RNAAEELKPRNKK-- CCHHHHHCCCCCC--	45.25	23806337

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of RAE1L_MOUSE !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of RAE1L_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of RAE1L_MOUSE !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of RAE1L_MOUSE !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of RAE1L_MOUSE

Related Literatures of Post-Translational Modification